Imperial College London
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Dr Ranil De Silva

Faculty of Medicine, National Heart & Lung Institute

Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7351 8626r.desilva Website

 
 
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Assistant

 

Ms Deborah Curcher +44 (0)20 7351 8626

 
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Location

 

Chelsea WingSydney StreetRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fair:2020:10.21542/gcsp.2020.38,
author = {Fair, MJ and Gatehouse, PD and Reyes, E and Adluru, G and Mendes, J and Khan, T and de, Silva R and Wage, R and DiBella, EVR and Firmin, DN},
doi = {10.21542/gcsp.2020.38},
journal = {Glob Cardiol Sci Pract},
title = {Initial investigation of free-breathing 3D whole-heart stress myocardial perfusion MRI.},
url = {http://dx.doi.org/10.21542/gcsp.2020.38},
volume = {2020},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective: Myocardial first-pass perfusion imaging with MRI is well-established clinically. However, it is potentially weakened by limited myocardial coverage compared to nuclear medicine. Clinical evaluations of whole-heart MRI perfusion by 3D methods, while promising, have to date had the limit of breathhold requirements at stress. This work aims to develop a new free-breathing 3D myocardial perfusion method, and to test its performance in a small patient population. Methods: This work required tolerance to respiratory motion for stress investigations, and therefore employed a "stack-of-stars" hybrid Cartesian-radial MRI acquisition method. The MRI sequence was highly optimised for rapid acquisition and combined with a compressed sensing reconstruction. Stress and rest datasets were acquired in four healthy volunteers, and in six patients with coronary artery disease (CAD), which were compared against clinical reference information. Results: This free-breathing method produced datasets that appeared consistent with clinical reference data in detecting moderate-to-strong induced perfusion abnormalities. However, the majority of the mild defects identified clinically were not detected by the method, potentially due to the presence of transient myocardial artefacts present in the images. Discussion: The feasibility of detecting CAD using this 3D first-pass perfusion sequence during free-breathing is demonstrated. Good agreement on typical moderate-to-strong CAD cases is promising, however, questions still remain on the sensitivity of the technique to milder cases.
AU  - Fair,MJ
AU  - Gatehouse,PD
AU  - Reyes,E
AU  - Adluru,G
AU  - Mendes,J
AU  - Khan,T
AU  - de,Silva R
AU  - Wage,R
AU  - DiBella,EVR
AU  - Firmin,DN
DO  - 10.21542/gcsp.2020.38
PY  - 2020///
SN  - 2305-7823
TI  - Initial investigation of free-breathing 3D whole-heart stress myocardial perfusion MRI.
T2  - Glob Cardiol Sci Pract
UR  - http://dx.doi.org/10.21542/gcsp.2020.38
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33598498
VL  - 2020
ER  -
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