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@article{Raphael:2016:10.1186/s12968-016-0312-8,
author = {Raphael, CE and Keegan, J and Parker, KH and Simpson, R and Collinson, J and Vassiliou, V and Wage, R and Drivas, P and Strain, S and Cooper, R and de, Silva R and Stables, RH and Di, Mario C and Frenneaux, M and Pennell, DJ and Davies, JE and Hughes, AD and Firmin, D and Prasad, SK},
doi = {10.1186/s12968-016-0312-8},
journal = {Journal of Cardiovascular Magnetic Resonance},
title = {Feasibility of cardiovascular magnetic resonance derived coronary wave intensity analysis},
url = {http://dx.doi.org/10.1186/s12968-016-0312-8},
volume = {18},
year = {2016}
}

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TY  - JOUR
AB  - BackgroundWave intensity analysis (WIA) of the coronary arteries allows description of the predominant mechanisms influencing coronary flow over the cardiac cycle. The data are traditionally derived from pressure and velocity changes measured invasively in the coronary artery. Cardiovascular magnetic resonance (CMR) allows measurement of coronary velocities using phase velocity mapping and derivation of central aortic pressure from aortic distension. We assessed the feasibility of WIA of the coronary arteries using CMR and compared this to invasive data.MethodsCMR scans were undertaken in a serial cohort of patients who had undergone invasive WIA. Velocity maps were acquired in the proximal left anterior descending and proximal right coronary artery using a retrospectively-gated breath-hold spiral phase velocity mapping sequence with high temporal resolution (19 ms). A breath-hold segmented gradient echo sequence was used to acquire through-plane cross sectional area changes in the proximal ascending aorta which were used as a surrogate of an aortic pressure waveform after calibration with brachial blood pressure measured with a sphygmomanometer. CMR-derived aortic pressures and CMR-measured velocities were used to derive wave intensity. The CMR-derived wave intensities were compared to invasive data in 12 coronary arteries (8 left, 4 right). Waves were presented as absolute values and as a % of total wave intensity. Intra-study reproducibility of invasive and non-invasive WIA was assessed using Bland-Altman analysis and the intraclass correlation coefficient (ICC).ResultsThe combination of the CMR-derived pressure and velocity data produced the expected pattern of forward and backward compression and expansion waves. The intra-study reproducibility of the CMR derived wave intensities as a % of the total wave intensity (mean ± standard deviation of differences) was 0.0 ± 6.8%, ICC = 0.91. Intra-study reproducib
AU  - Raphael,CE
AU  - Keegan,J
AU  - Parker,KH
AU  - Simpson,R
AU  - Collinson,J
AU  - Vassiliou,V
AU  - Wage,R
AU  - Drivas,P
AU  - Strain,S
AU  - Cooper,R
AU  - de,Silva R
AU  - Stables,RH
AU  - Di,Mario C
AU  - Frenneaux,M
AU  - Pennell,DJ
AU  - Davies,JE
AU  - Hughes,AD
AU  - Firmin,D
AU  - Prasad,SK
DO  - 10.1186/s12968-016-0312-8
PY  - 2016///
SN  - 1532-429X
TI  - Feasibility of cardiovascular magnetic resonance derived coronary wave intensity analysis
T2  - Journal of Cardiovascular Magnetic Resonance
UR  - http://dx.doi.org/10.1186/s12968-016-0312-8
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000390906000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/43715
VL  - 18
ER  -

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