Publications
112 results found
Dina RE, 2016, The British Classification of thyroid cytology: reproducibility, positive predictive value and impact of the MultiDisciplinary Team discussion, 19th International Congress of Cytology
Marchio C, Barroca H, Dina R, et al., 2016, CyTEST- A Pan European Project for Training & Testing in Cytopathology, 105th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, Publisher: NATURE PUBLISHING GROUP, Pages: 142A-142A, ISSN: 0893-3952
Marchio C, Barroca H, Dina R, et al., 2016, CyTEST-A Pan European Project for Training & Testing in Cytopathology, 105th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, Publisher: NATURE PUBLISHING GROUP, Pages: 142A-142A, ISSN: 0023-6837
Gungor H, Saleem A, Babar S, et al., 2015, Dose-finding quantitative F-18-FDG PET imaging study with the oral pan-AKT inhibitor GSK2141795 in patients with gynecologic malignancies, Journal of Nuclear Medicine, Vol: 56, Pages: 1828-1835, ISSN: 1535-5667
AKT (a serine/threonine-specific protein kinase) regulates many cellular processes contributing to cytotoxic drug resistance. This study’s primary objective examined the relationship between GSK2141795, an oral, pan-AKT inhibitor, and 18F-FDG PET markers of glucose metabolism in tumor tissue to determine whether 18F-FDG PET could be used to guide personalized dosing of GSK2141795. Biomarker analysis of biopsies was also undertaken. Methods: Twelve patients were enrolled in 3 cohorts; all underwent dynamic 18F-FDG PET scans and serial pharmacokinetic sampling at baseline, week 2, and week 4 with tumor biopsies before treatment and at week 4. Response was evaluated by RECIST v1.1 and Gynecologic Cancer Intergroup criteria. Biopsy samples were analyzed for mutations and protein expression. Results: GSK2141795 did not significantly influence blood glucose levels. No dose–response relationship was observed between GSK2141795 pharmacokinetics and 18F-FDG PET pharmacodynamic measures; however, an exposure–response relationship was seen between maximum drug concentrations and maximal decrease in 18F-FDG uptake in the best-responding tumor. This relationship also held for pharmacokinetic parameters of exposure and 1,5-anhydroglucitol (a systemic measure of glucose metabolism). Phospho-AKT upregulation at week 4 in biopsies confirmed AKT inhibition by GSK2141795. Single-agent activity was observed with a clinical benefit rate of 27% (3/11) and 30% (3/10) CA125 response in the study’s platinum-resistant ovarian patients. AKT pathway activation by PIK3CA/PIK3R1 mutation did not correlate with clinical activity, whereas RAS/RAF pathway mutations did segregate with resistance to AKT inhibition. Conclusion: GSK2141795 demonstrated an exposure–response relationship with decreased 18F-FDG uptake and is active and tolerable. This study’s design integrating 18F-FDG PET, pharmacokinetics, and biomarker analyses demonstrates the potential for clinical
McFarland M, Dina R, Fisher C, et al., 2015, Osteosarcoma as Malignant Mural Nodule in Ovarian Mucinous Neoplasms of Intestinal Type: Report of 2 Cases, INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, Vol: 34, Pages: 369-373, ISSN: 0277-1691
- Author Web Link
- Cite
- Citations: 10
Miller HC, Kidd M, Modlin IM, et al., 2015, Glucagon receptor gene mutations with hyperglucagonemia but without the glucagonoma syndrome, World Journal of Gastrointestinal Surgery, Vol: 7, Pages: 60-66, ISSN: 1948-9366
Pancreatic neoplasms producing exclusively glucagon associated with glucagon cell hyperplasia of the islets and not related to hereditary endocrine syndromes have been recently described. They represent a novel entity within the panel of non-syndromic disorders associated with hyperglucagonemia. This case report describes a 36-year-old female with a 10 years history of non-specific abdominal pain. No underlying cause was evident despite extensive diagnostic work-up. More recently she was diagnosed with gall bladder stones. Abdominal ultrasound, computerised tomography and magnetic resonance imaging revealed no pathologic findings apart from cholelithiasis. Endoscopic ultrasound revealed a 5.5 mm pancreatic lesion. Fine needle aspiration showed cells focally expressing chromogranin, suggestive but not diagnostic of a low grade neuroendocrine tumor. OctreoScan(®) was negative. Serum glucagon was elevated to 66 pmol/L (normal: 0-50 pmol/L). Other gut hormones, chromogranin A and chromogranin B were normal. Cholecystectomy and enucleation of the pancreatic lesion were undertaken. Postoperatively, abdominal symptoms resolved and serum glucagon dropped to 7 pmol/L. Although H and E staining confirmed normal pancreatic tissue, immunohistochemistry was initially thought to be suggestive of alpha cell hyperplasia. A count of glucagon positive cells from 5 islets, compared to 5 islets from 5 normal pancreata indicated that islet size and glucagon cell ratios were increased, however still within the wide range of normal physiological findings. Glucagon receptor gene (GCGR) sequencing revealed a heterozygous deletion, K349_G359del and 4 missense mutations. This case may potentially represent a progenitor stage of glucagon cell adenomatosis with hyperglucagonemia in the absence of glucagonoma syndrome. The identification of novel GCGR mutations suggests that these may represent the underlying cause of this condition.
Badran A, Ellis P, Dina R, 2015, Lymphocyte Populations in Endometrial Cancer of Young Women: An Immunohistochemical Study on TMA, Publisher: SPRINGERNATURE, Pages: 274A-274A, ISSN: 0893-3952
Badran A, Ellis P, Dina R, 2015, CXCL12 and CXCL3 Expression in Young Women With Endometrial Cancer, Publisher: SPRINGERNATURE, Pages: 274A-274A, ISSN: 0893-3952
Badran A, Ellis P, Dina R, 2015, CXCL12 and CXCL3 Expression in Young Women With Endometrial Cancer, 104th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, Publisher: NATURE PUBLISHING GROUP, Pages: 274A-274A, ISSN: 0023-6837
Badran A, Ellis P, Dina R, 2015, Lymphocyte Populations in Endometrial Cancer of Young Women: An Immunohistochemical Study on TMA, 104th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, Publisher: NATURE PUBLISHING GROUP, Pages: 274A-274A, ISSN: 0023-6837
Hadjisavva IS, Dina R, Talias MA, et al., 2015, Prevalence of Cancer in Patients with Thyroid Nodules in the Island of Cyprus: Predictive Value of Ultrasound Features and Thyroid Autoimmune Status, EUROPEAN THYROID JOURNAL, Vol: 4, Pages: 123-128, ISSN: 2235-0640
- Author Web Link
- Cite
- Citations: 11
Trousil S, Lee P, Pinato DJ, et al., 2014, Alterations of choline phospholipid metabolism in endometrial cancer are caused by choline kinase alpha overexpression and a hyperactivated deacylation pathway, Cancer Research, Vol: 74, Pages: 6867-6877, ISSN: 0008-5472
Metabolic rearrangements subsequent to malignant transformation are not well characterized in endometrial cancer. Identification of altered metabolites could facilitate imaging-guided diagnosis, treatment surveillance, and help to identify new therapeutic options. Here, we used high-resolution magic angle spinning magnetic resonance mass spectroscopy on endometrial cancer surgical specimens and normal endometrial tissue to investigate the key modulators that might explain metabolic changes, incorporating additional investigations using qRT-PCR, Western blotting, tissue microarrays (TMA), and uptake assays of [3H]-labeled choline. Lipid metabolism was severely dysregulated in endometrial cancer with various amino acids, inositols, nucleobases, and glutathione also altered. Among the most important lipid-related alterations were increased phosphocholine levels (increased 70% in endometrial cancer). Mechanistic investigations revealed that changes were not due to altered choline transporter expression, but rather due to increased expression of choline kinase α (CHKA) and an activated deacylation pathway, as indicated by upregulated expression of the catabolic enzymes LYPLA1, LYPLA2, and GPCPD1. We confirmed the significance of CHKA overexpression on a TMA, including a large series of endometrial hyperplasia, atypical hyperplasia, and adenocarcinoma tissues, supporting a role for CHKA in malignant transformation. Finally, we documented several-fold increases in the uptake of [3H]choline in endometrial cancer cell lines compared with normal endometrial stromal cells. Our results validate deregulated choline biochemistry as an important source of noninvasive imaging biomarkers for endometrial cancer. Cancer Res; 74(23); 6867–77. ©2014 AACR.
Herbert A, Anic V, Cochand-Priollet B, et al., 2014, Training and practice of cytotechnologists: a discussion forum focused on Europe, CYTOPATHOLOGY, Vol: 25, Pages: 307-315, ISSN: 0956-5507
- Author Web Link
- Cite
- Citations: 14
Guran R, Dina R, 2014, Axillary lymph nodes involvement by ovarian serous tumours of low malignant potential: a report of two cases, VIRCHOWS ARCHIV, Vol: 465, Pages: S350-S350, ISSN: 0945-6317
Pinato DJ, Tan TM, Toloue S, et al., 2013, An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes., British Journal of Cancer, Vol: 110, ISSN: 1532-1827
Fotopoulou C, Spiers L, Adjogatse D, et al., 2013, Management of ascites via the alfa-pump closed system in platinum-resistant-ovarian-cancer (PROC): A model of sequential non-invasive tumor-cell sampling through the urinary bladder, CLINICAL CANCER RESEARCH, Vol: 19, ISSN: 1078-0432
Fotopoulou C, Spiers L, Pickford E, et al., 2013, CONTINUOUS LOW-FLOW ASCITES-DRAINAGE AND SEQUENTIAL NON-INVASIVE TUMOR-CELL SAMPLING THROUGH THE URINARY BLADDER VIA THE ALFA-PUMP CLOSED SYSTEM IN PLATINUM-RESISTANT-OVARIAN-CANCER (PROC), INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 23, ISSN: 1048-891X
Pinato DJ, Tan TM, Toloue-Kalami-Toussi S, et al., 2013, AN EXPRESSION SIGNATURE OF THE ANGIOGENIC RESPONSE IN GASTROINTESTINAL NEUROENDOCRINE TUMOURS: CORRELATION WITH TUMOUR PHENOTYPE AND SURVIVAL OUTCOMES, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A29-A29, ISSN: 0017-5749
Chatterjee J, Howden S, Saso S, et al., 2013, Low grade fibromyxoid sarcoma of the genital tract: a rare soft tissue tumour, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 120, Pages: 253-254, ISSN: 1470-0328
Chatterjee J, Hopkins T, Wahba J, et al., 2013, Early stage mucinous ovarian carcinomas: 10 years of experience in a tertiary centre, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 120, Pages: 282-283, ISSN: 1470-0328
Dina R, Tran-Dang M-A, Mauri F, et al., 2013, Pancreatobiliary cytology in the multidisciplinary setting, CYTOPATHOLOGY, Vol: 24, Pages: 150-158, ISSN: 0956-5507
- Author Web Link
- Cite
- Citations: 6
Fotopoulou C, Spiers L, Pickford E, et al., 2013, Continuous low-flow ascites drainage and sequential non-invasive tumor-cell sampling through the urinary bladder via the alfa-pump closed system in platinum-resistant ovarian cancer (PROC): First clinical experience in a cancer patient., 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0732-183X
Pinato DJ, Ramachandran R, Toussi STK, et al., 2013, Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations, BRITISH JOURNAL OF CANCER, Vol: 108, Pages: 429-437, ISSN: 0007-0920
- Author Web Link
- Cite
- Citations: 34
Dina R, Argamosa D, 2012, The NHS Cervical Screening Programme criteria for evaluating cervical cytology: comparison of the new with the old, CYTOPATHOLOGY, Vol: 23, Pages: 349-352, ISSN: 0956-5507
- Author Web Link
- Cite
- Citations: 1
Dina R, Tallini G, Economides P, et al., 2012, Molecular Testing for Mutations to Improve Pre-operative Management of Patients with Thyroid Nodules, 202nd Summer Scientific Meeting of the Pathological-Society-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: S16-S16, ISSN: 0022-3417
Mura M, Abd Latip N, Michael T, et al., 2012, LARP1 Regulates the Site-specific Synthesis of Proteins Required for Cancer Cell Invasion and Migration, 22nd Biennial Congress of the European-Association-for-Cancer-Research, Publisher: ELSEVIER SCI LTD, Pages: S77-S77, ISSN: 0959-8049
Crippa S, Dina R, 2012, Interobserver Reproducibility of Thyroid Fine-Needle Aspiration Using the UK Royal College of Pathologists' Classification System, AMERICAN JOURNAL OF CLINICAL PATHOLOGY, Vol: 137, Pages: 833-835, ISSN: 0002-9173
Maroo N, Dina RE, 2012, Correlation of CXCL12/CXCR4 Expression and FOXP3 Cell Infiltration in Normal Endometrium,Typical and Atypical Hyperplasia and Endometrioid Adenocarcinoma, 101st Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, Publisher: NATURE PUBLISHING GROUP, Pages: 286A-286A, ISSN: 0893-3952
Maroo N, Dina RE, 2012, Correlation of CXCL12/CXCR4 Expression and FOXP3 Cell Infiltration in Normal Endometrium, Typical and Atypical Hyperplasia and Endometrioid Adenocarcinoma, 101st Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP), Publisher: NATURE PUBLISHING GROUP, Pages: 286A-286A, ISSN: 0023-6837
- Author Web Link
- Cite
- Citations: 1
Rahman NA, Bennink HJTC, Chrusciel M, et al., 2012, A novel treatment strategy for ovarian cancer based on immunization against zona pellucida protein (ZP) 3, FASEB JOURNAL, Vol: 26, Pages: 324-333, ISSN: 0892-6638
- Author Web Link
- Cite
- Citations: 8
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.