Imperial College London
DR ROBERTO DINA MD, FIAC, FRCPath

DR ROBERTO DINA MD, FIAC, FRCPath

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)7753 719 480r.dina Website

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Khalil:2018:10.1159/000484600,
author = {Khalil, AB and Dina, R and Meeran, K and Bakir, AM and Naqvi, S and Al, Tikritti A and Lessan, N and Barakat, MT},
doi = {10.1159/000484600},
journal = {European Thyroid Journal},
pages = {39--43},
title = {Indeterminate thyroid nodules: a pragmatic approach},
url = {http://dx.doi.org/10.1159/000484600},
volume = {7},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Fine needle aspiration (FNA) cytology fails to provide a conclusive diagnosis in a subset of thyroid lesions labeled as “indeterminate” (Thy3). In this study, we aimed at ascertaining the prevalence of Thy3 thyroid nodules in a hitherto unreported ethnic group (residents of the United Arab Emirates). Methods: We retrospectively examined 688 FNA of the thyroid performed on 584 patients. Samples were reported using the Royal College of Physicians’ (RCP) Thy classification. The results of the FNA were correlated with the final surgical specimens. Ultrasonography (US) risk stratification was calculated using a web-based US risk of malignancy calculator. Results: Overall sample adequacy was 97%. The indeterminate group Thy3 was found in 7% of the samples. The overall risk of malignancy in the Thy3 category was 20%. This risk was very similar in the 2 subgroups of Thy3 (17% in Thy 3a and 22% in Thy3f). Subdividing the Thy3 group into subgroups becomes less necessary if the US scoring is <24.5% since the negative predictive value, in this case, is 100%. Applying this criterion to our population would have had the potential of reducing the percentage of patients referred to surgery from 61 to 43%. Conclusions: Proper risk stratification of Thy3 lesions should be based on the combined risk assessment of clinical, cytological, radiological, and molecular data. Such a pragmatic approach is expected to reduce the percentage of inappropriate referrals to surgery.
AU  - Khalil,AB
AU  - Dina,R
AU  - Meeran,K
AU  - Bakir,AM
AU  - Naqvi,S
AU  - Al,Tikritti A
AU  - Lessan,N
AU  - Barakat,MT
DO  - 10.1159/000484600
EP  - 43
PY  - 2018///
SN  - 2235-0802
SP  - 39
TI  - Indeterminate thyroid nodules: a pragmatic approach
T2  - European Thyroid Journal
UR  - http://dx.doi.org/10.1159/000484600
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000428577800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://etj.bioscientifica.com/view/journals/etj/7/1/ETJ484600.xml
VL  - 7
ER  -
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