Publications
427 results found
Ethier CR, Goyal V, Sanchez-Rodriguez G, et al., 2021, Deep learning (DL)-based morphometric analysis of retinal ganglion cell (RGC) axons in a rat model of glaucoma, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Dattilo M, Brown D, Ethier CR, 2021, Comparison of Optic Nerve Sheath Material Properties in male and female rhesus macaque, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Goyal V, Sanchez-Rodriguez G, Hannon B, et al., 2021, AxoNet 2.0: A deep learning (DL)-based tool for morphometric analysis of retinal ganglion cell (RGC) axons, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
- Author Web Link
- Cite
- Citations: 1
Foltz J, Schildmeyer L, Han W, et al., 2021, Morphometric analysis of rat optic nerve head (ONH) astrocytes grown in a 3D cell culture system, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Feola A, Ethier CR, Samuels BC, 2021, Effects of Multiple Pathological Stimuli on Optic Nerve Head Deformation, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Ethier CR, 2021, Editorial: A Message From C. Ross Ethier, the New JBME Co-Editor, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 143, ISSN: 0148-0731
Sater SH, Sass AM, Seiner A, et al., 2021, MRI-based quantification of ophthalmic changes in healthy volunteers during acute 15° head-down tilt as an analogue to microgravity, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 18, ISSN: 1742-5689
- Author Web Link
- Cite
- Citations: 1
Safa BN, Read AT, Ethier CR, 2021, Assessment of the Viscoelastic Mechanical Properties of the Porcine Optic Nerve Head using Micromechanical Testing and Finite Element Modeling
<jats:title>Abstract</jats:title><jats:p>Optic nerve head (ONH) biomechanics is centrally involved in the pathogenesis of glaucoma, a blinding ocular condition often characterized by elevation and fluctuation of the intraocular pressure and resulting loads on the ONH. Further, tissue viscoelasticity is expected to strongly influence the mechanical response of the ONH to mechanical loading, yet the viscoelastic mechanical properties of the ONH remain unknown. To determine these properties, we conducted micromechanical testing on porcine ONH tissue samples, coupled with finite element modeling based on a mixture model consisting of a biphasic material with a viscoelastic solid matrix. Our results provide a detailed description of the viscoelastic properties of the porcine ONH at each of its four anatomical quadrants (i.e., nasal, superior, temporal, and inferior). We showed that the ONH’s viscoelastic mechanical response can be explained by a dual mechanism of fluid flow and solid matrix viscoelasticity, as is common in other soft tissues. We obtained porcine ONH properties as follows: matrix Young’s modulus <jats:italic>E</jats:italic>=1.895 [1.056,2 .391] kPa (median [min., max.]), Poisson’s ratio <jats:italic>ν</jats:italic>=0.142 [0.060,0 .312], kinetic time-constant <jats:italic>τ</jats:italic>=214 [89,921] sec, and hydraulic permeability <jats:italic>k</jats:italic>=3.854 × 10<jats:sup>−1</jats:sup> [3.457 × 10<jats:sup>−2</jats:sup>,9.994 × 10<jats:sup>−1</jats:sup>] mm<jats:sup>4</jats:sup>/(N sec). These values can be used to design and fabricate physiologically appropriate <jats:italic>ex vivo</jats:italic> test environments (e.g., 3D cell culture) to further understand glaucoma pathophysiology.</jats:p>
Yun H, Wang Y, Zhou Y, et al., 2021, Human stem cells home to and repair laser-damaged trabecular meshwork in a mouse model (vol 6, 216, 2018), COMMUNICATIONS BIOLOGY, Vol: 4
Yun H, Wang Y, Zhou Y, et al., 2021, Human stem cells home to and repair laser-damaged trabecular meshwork in a mouse model (vol 6, 216, 2018), COMMUNICATIONS BIOLOGY, Vol: 4
Schwaner SA, Perry RN, Kight AM, et al., 2021, Individual-Specific Modeling of Rat Optic Nerve Head Biomechanics in Glaucoma, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 143, ISSN: 0148-0731
- Author Web Link
- Cite
- Citations: 6
Gerberich BG, Hannon BG, Hejri A, et al., 2021, Transpupillary collagen photocrosslinking for targeted modulation of ocular biomechanics, BIOMATERIALS, Vol: 271, ISSN: 0142-9612
- Author Web Link
- Cite
- Citations: 9
Li G, Lee C, Read AT, et al., 2021, Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis, ELIFE, Vol: 10, ISSN: 2050-084X
- Author Web Link
- Cite
- Citations: 22
Safa BN, Santare MH, Ethier CR, et al., 2021, Identifiability of tissue material parameters from uniaxial tests using multi-start optimization, ACTA BIOMATERIALIA, Vol: 123, Pages: 197-207, ISSN: 1742-7061
- Author Web Link
- Cite
- Citations: 6
Snider EJ, Hardie BA, Li Y, et al., 2021, A Porcine Organ-Culture Glaucoma Model Mimicking Trabecular Meshwork Damage Using Oxidative Stress, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 62, ISSN: 0146-0404
- Author Web Link
- Cite
- Citations: 6
Zhu W, Hou F, Fang J, et al., 2021, The role of Piezo1 in conventional aqueous humor outflow dynamics, iScience, Vol: 24, Pages: 1-32, ISSN: 2589-0042
Controlling intraocular pressure (IOP) remains the mainstay of glaucoma therapy. The trabecular meshwork (TM), the key tissue responsible for aqueous humor (AH) outflow and IOP maintenance, is very sensitive to mechanical forces. However, it is not understood whether Piezo channels, very sensitive mechanosensors, functionally influence AH outflow. Here, we characterize the role of Piezo1 in conventional AH outflow. Immunostaining and western blot analysis showed that Piezo1 is widely expressed by TM. Patch-clamp recordings in TM cells confirmed the activation of Piezo1-derived mechanosensitive currents. Importantly, the antagonist GsMTx4 for mechanosensitive channels significantly decreased steady-state facility, yet activation of Piezo1 by the specific agonist Yoda1 did not lead to a facility change. Furthermore, GsMTx4, but not Yoda1, caused a significant increase in ocular compliance, a measure of the eye's transient response to IOP perturbation. Our findings demonstrate a potential role for Piezo1 in conventional outflow, likely under pathological and rapid transient conditions.
Zahid AM, Martin B, Collins S, et al., 2021, Quantification of arterial, venous, and cerebrospinal fluid flow dynamics by magnetic resonance imaging under simulated micro-gravity conditions: a prospective cohort study, FLUIDS AND BARRIERS OF THE CNS, Vol: 18, ISSN: 2045-8118
- Author Web Link
- Cite
- Citations: 5
Boazak EM, King R, Wang J, et al., 2021, Smarce1 and Tensin 4 are putative modulators of corneoscleral stiffness, Frontiers in Bioengineering and Biotechnology, Vol: 9, Pages: 1-13, ISSN: 2296-4185
The biomechanical properties of the cornea and sclera are important in the onset and progression of multiple ocular pathologies and vary substantially between individuals, yet the source of this variation remains unknown. Here we identify genes putatively regulating corneoscleral biomechanical tissue properties by conducting high-fidelity ocular compliance measurements across the BXD recombinant inbred mouse set and performing quantitative trait analysis. We find seven cis-eQTLs and non-synonymous SNPs associating with ocular compliance, and show by RT-qPCR and immunolabeling that only two of the candidate genes, Smarce1 and Tns4, showed significant expression in corneal and scleral tissues. Both have mechanistic potential to influence the development and/or regulation of tissue material properties. This work motivates further study of Smarce1 and Tns4 for their role(s) in ocular pathology involving the corneoscleral envelope as well as the development of novel mouse models of ocular pathophysiology, such as myopia and glaucoma.
Brown DM, Pardue MT, Ethier CR, 2021, A biphasic approach for characterizing tensile, compressive and hydraulic properties of the sclera, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 18, ISSN: 1742-5689
- Author Web Link
- Cite
- Citations: 6
Hannon BG, Feola AJ, Gerberich BG, et al., 2021, Using retinal function to define ischemic exclusion criteria for animal models of glaucoma, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, ISSN: 0014-4835
- Author Web Link
- Cite
- Citations: 7
Chae JJ, Prausnitz MR, Ethier CR, 2021, Effects of General Anesthesia on Intraocular Pressure in Rabbits, JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE, Vol: 60, Pages: 91-95, ISSN: 1559-6109
- Author Web Link
- Cite
- Citations: 8
Lee C, Li G, Stamer WD, et al., 2021, <i>In vivo</i> estimation of murine iris stiffness using finite element modeling, EXPERIMENTAL EYE RESEARCH, Vol: 202, ISSN: 0014-4835
- Author Web Link
- Cite
- Citations: 3
Chae JJ, Jung JH, Zhu W, et al., 2021, Drug-Free, Nonsurgical Reduction of Intraocular Pressure for Four Months after Suprachoroidal Injection of Hyaluronic Acid Hydrogel, ADVANCED SCIENCE, Vol: 8
- Author Web Link
- Cite
- Citations: 16
Schwaner SA, Hannon BG, Feola AJ, et al., 2020, Biomechanical properties of the rat sclera obtained with inverse finite element modeling, BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Vol: 19, Pages: 2195-2212, ISSN: 1617-7959
- Author Web Link
- Cite
- Citations: 9
Rohr JJ, Sater S, Sass AM, et al., 2020, Quantitative magnetic resonance image assessment of the optic nerve and surrounding sheath after spaceflight, NPJ MICROGRAVITY, Vol: 6
- Author Web Link
- Cite
- Citations: 8
Rohr JJ, Sater S, Sass AM, et al., 2020, Quantitative magnetic resonance image assessment of the optic nerve and surrounding sheath after spaceflight., NPJ Microgravity, Vol: 6, ISSN: 2373-8065
A subset of long-duration spaceflight astronauts have experienced ophthalmic abnormalities, collectively termed spaceflight-associated neuro-ocular syndrome (SANS). Little is understood about the pathophysiology of SANS; however, microgravity-induced alterations in intracranial pressure (ICP) due to headward fluid shifts is the primary hypothesized contributor. In particular, potential changes in optic nerve (ON) tortuosity and ON sheath (ONS) distension may indicate altered cerebrospinal fluid dynamics during weightlessness. The present longitudinal study aims to provide a quantitative analysis of ON and ONS cross-sectional areas, and ON deviation, an indication of tortuosity, before and after spaceflight. Ten astronauts undergoing ~6-month missions on the International Space Station (ISS) underwent high-resolution magnetic resonance imaging (MRI) preflight and at five recovery time points extending to 1 year after return from the ISS. The mean changes in ON deviation, ON cross-sectional area, and ONS cross-sectional area immediately post flight were -0.14 mm (95% CI: -0.36 to 0.08, Bonferroni-adjusted P = 1.00), 0.13 mm2 (95% CI -0.66 to 0.91, Bonferroni-adjusted P = 1.00), and -0.22 mm2 (95% CI: -1.78 to 1.34, Bonferroni-adjusted P = 1.00), respectively, and remained consistent during the recovery period. Terrestrially, ONS distension is associated with increased ICP; therefore, these results suggest that, on average, ICP was not pathologically elevated immediately after spaceflight. However, a subject diagnosed with optic disc edema (Frisen Grade 1, right eye) displayed increased ONS area post flight, although this increase is relatively small compared to clinical populations with increased ICP. Advanced quantitative MRI-based assessment of the ON and ONS could help our understanding of SANS and the role of ICP.
Lee C, Rohr J, Sass A, et al., 2020, In vivo estimation of optic nerve sheath stiffness using noninvasive MRI measurements and finite element modeling, JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, Vol: 110, ISSN: 1751-6161
- Author Web Link
- Cite
- Citations: 9
Hannon BG, Luna C, Feola AJ, et al., 2020, Assessment of Visual and Retinal Function Following In Vivo Genipin-Induced Scleral Crosslinking, TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, Vol: 9, ISSN: 2164-2591
- Author Web Link
- Cite
- Citations: 10
Li G, Schmitt H, Johnson WM, et al., 2020, Integral role for lysyl oxidase-like-1 in conventional outflow tissue function and behavior, FASEB JOURNAL, Vol: 34, Pages: 10762-10777, ISSN: 0892-6638
- Author Web Link
- Cite
- Citations: 11
Ross Ethier C, Caro CG, Diller KR, et al., 2020, In Memoriam Robert M. Nerem, 1937-2020, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 142, ISSN: 0148-0731
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.