Imperial College London
Alternate

DrRosemaryFisher

Faculty of Medicine, Department of Surgery & Cancer

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3311 1413r.fisher

 
 
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Location

 

Medical OncologyCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fisher:2021:10.1016/j.bpobgyn.2021.01.004,
author = {Fisher, RA},
doi = {10.1016/j.bpobgyn.2021.01.004},
journal = {Best Practice and Research: Clinical Obstetrics and Gynaecology},
pages = {29--41},
title = {Genetics of gestational trophoblastic disease},
url = {http://dx.doi.org/10.1016/j.bpobgyn.2021.01.004},
volume = {74},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The abnormal pregnancies complete and partial hydatidiform mole are genetically unusual, being associated with two copies of the paternal genome. Typical complete hydatidiform moles (CHMs) are diploid and androgenetic, while partial hydatidiform moles (PHMs) are diandric triploids. While diagnosis can usually be made on the basis of morphology, ancillary techniques that exploit their unusual genetic origin can be used to facilitate diagnosis. Genotyping and p57 immunostaining are now routinely used in the differential diagnosis of complete and partial hydatidiform moles, for investigating unusual mosaic or chimeric products of conception with a molar component and identifying the rare diploid, biparental HMs associated with an inherited predisposition to molar pregnancies. Genotyping also plays an important role in the differential diagnosis of gestational and non-gestational trophoblastic tumours and identification of the causative pregnancy where tumours are gestational. Recent developments include the use of cell-free DNA for non-invasive diagnosis of these conditions.
AU  - Fisher,RA
DO  - 10.1016/j.bpobgyn.2021.01.004
EP  - 41
PY  - 2021///
SN  - 1521-6934
SP  - 29
TI  - Genetics of gestational trophoblastic disease
T2  - Best Practice and Research: Clinical Obstetrics and Gynaecology
UR  - http://dx.doi.org/10.1016/j.bpobgyn.2021.01.004
UR  - https://www.sciencedirect.com/science/article/pii/S1521693421000110?via%3Dihub
UR  - http://hdl.handle.net/10044/1/88948
VL  - 74
ER  -
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