Imperial College London

DrRohmaGhani

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Clinical Research Fellow
 
 
 
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Contact

 

r.ghani

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

31 results found

Innes AJ, Mullish BH, Ghani R, Szydlo RM, Apperley JF, Olavarria E, Palanicawandar R, Kanfer EJ, Milojkovic D, McDonald JAK, Brannigan ET, Thursz MR, Williams HRT, Davies FJ, Marchesi JR, Pavlu Jet al., 2021, Fecal microbiota transplant mitigates adverse outcomes in patients colonized with multidrug-resistant organisms undergoing allogeneic hematopoietic cell transplantation, Frontiers in Cellular and Infection Microbiology, ISSN: 2235-2988

The gut microbiome can be adversely affected by chemotherapy and antibiotics prior to hematopoietic cell transplantation (HCT).This affects graft success and increases susceptibility to multidrug-resistant organism (MDRO) colonization and infection. Weperformed an initial retrospective analysis of our use of fecal microbiota transplantation (FMT) from healthy donors as therapy forMDRO-colonized patients with hematological malignancy. FMT was performed on eight MDRO-colonized patients pre-HCT (FMT-MDROgroup), and outcomes compared with 11 MDRO colonized HCT patients from the same period. At 12 months, survival wassignificantly higher in the FMT-MDRO group (70% versus 36% p = 0.044). Post-HCT, fewer FMT-MDRO patients required intensivecare (0% versus 46%, P = 0.045) or experienced fever (0.29 versus 0.11 days, P = 0.027). Intestinal MDRO decolonization occurred in25% of FMT-MDRO patients versus 11% non-FMT MDRO patients. Despite the significant difference and statistically comparablepatient/transplant characteristics, as the sample size was small, a matched-pair analysis to non-MDRO colonized control cohorts(2:1 matching) was performed. At 12 months, the MDRO group who did not have an FMT had significantly lower survival (36.4%versus 61.9% respectively, p=0.012), and higher non relapse mortality (NRM; 60.2% versus 16.7% respectively, p=0.009) than theirpaired non-colonized cohort. There was no difference in survival (70% versus 43.4%, p=0.14) or NRM (12.5% versus 31.2%respectively, p=0.24) between the FMT-MDRO group and their paired cohort. Negative outcomes, including mortality associatedwith MDRO colonization, may be ameliorated by pre-HCT FMT, despite lack of intestinal decolonization. Further work is needed toexplore the observed benefit.

Journal article

Mullish BH, Ghani R, McDonald JAK, Davies F, Marchesi JRet al., 2021, Reply to Woodworth, et al, Clinical Infectious Diseases, Vol: 72, Pages: e924-e925, ISSN: 1058-4838

Journal article

Mullish BH, Innes AJ, Ghani R, Szydlo R, Williams HR, Thursz MR, Marchesi J, Davies F, Pavlu Jet al., 2021, FECAL MICROBIOTA TRANSPLANT PRIOR TO ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT IN PATIENTS COLONIZED WITH MULTI-DRUG RESISTANT ORGANISMS IS ASSOCIATED WITH IMPROVED SURVIVAL, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S168-S169, ISSN: 0016-5085

Conference paper

Ghani R, Mullish BH, McDonald JAK, Ghazy A, Williams HRT, Brannigan ET, Mookerjee S, Satta G, Gilchrist M, Duncan N, Corbett R, Innes AJ, Pavlu J, Thursz MR, Davies F, Marchesi JRet al., 2021, Disease prevention not decolonization – a model for fecal microbiota transplantation in patients colonized with multidrug-resistant organisms, Clinical Infectious Diseases, Vol: 72, Pages: 1444-1447, ISSN: 1058-4838

Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia and length of stay in 20 patients colonized/ infected with MDRO receiving FMT (compared to pre-FMT history, and a matched group not receiving FMT), despite modest decolonization rates.

Journal article

Ghani R, Mullish B, Innes A, Szydlo RM, Apperley JF, Olavarria E, Palanicawandar R, Kanfer E, Milojkovic D, McDonald JAK, Brannigan E, Thursz MR, Williams HRT, Davies FJ, Pavlu J, Marchesi Jet al., 2021, Faecal microbiota transplant (FMT) prior to allogeneic haematopoietic cell transplantation (HCT) in patients colonised with multidrug-resistant organisms (MDRO) results in improved survival, ECCMID

Conference paper

Innes AJ, Ghani R, Mullish BH, Szydlo R, Palanicawandar R, Olavarria E, Apperley JF, Thursz MR, Williams HR, Marchesi JR, Davies F, Pavlu Jet al., 2020, O105. Faecal microbiota transplant (FMT) can reduce the high NRM associated with multi-drug resistant organism (MDRO) colonisation prior to allogeneic HCT., The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation, Publisher: Springer Nature [academic journals on nature.com], Pages: 122-122, ISSN: 0268-3369

Conference paper

Ghani R, Mullish BH, 2020, Decision: Considerations for Use of Fecal Microbiota Transplantation in Special Patient Populations, The 6 Ds of Fecal Microbiota Transplantation: A Primer from Decision to Discharge and Beyond, Editors: Allegretti, Kassam, Publisher: Slack Incorporated, ISBN: 9781630917500

Book chapter

Ghani R, Mullish BH, McDonald JA, Ghazy A, Williams HR, Brannigan E, Satta G, Gilchrist M, Duncan N, Corbett R, Pavlu J, Innes AJ, Thursz MR, Davies F, Marchesi Jet al., 2020, 1144 FECAL MICROBIOTA TRANSPLANT FOR MULTI-DRUG RESISTANT ORGANISMS: IMPROVED CLINICAL OUTCOMES BEYOND INTESTINAL DECOLONISATION, Publisher: Elsevier BV, ISSN: 0016-5085

Conference paper

Ghani R, Mullish BH, Mcdonald J, Williams H, Gilchrist M, Brannigan E, Satta G, Taube D, Duncan N, Pavlu J, Ghazy A, Thursz M, Davies F, Marchesi Jet al., 2020, Cohort study of Faecal Microbiota Transplantation for patient’s colonised with MDROs - successful prevention of invasive disease despite low decolonisation rates, Access Microbiology, Vol: 2

Journal article

Ghani R, Mullish BH, Thursz M, Marchesi J, Ghazy A, Davies Fet al., 2020, Case-control study of recurrent Extended-Spectrum Beta Lactamase Enterobacteriaceae Urinary Tract Infections (ESBL UTIs): the management challenges, Access Microbiology, Vol: 2

Journal article

Ghani R, Mullish BH, McDonald J, Ghazy A, Williams H, Satta G, Eimear B, Gilchrist M, Duncan N, Corbett R, Pavlu J, Innes A, Thursz M, Marchesi J, Davies Fet al., 2020, Disease prevention not decolonisation: a cohort study for faecal microbiota transplantation for patients colonised with multidrug-resistant organisms, ECCMID 2020

Conference paper

Ghani R, Gan C, Mullish BH, Ferizoli V, Davies F, Thursz MR, Marchesi JR, Dasgupta R, Minhas Set al., 2019, P13-2 Prevalence of recurrent Extended Spectrum Beta-Lactamase (ESBL) urinary tract infections (UTIs) in patients within a Urology service and introducing the concept of Faecal Microbiota Transplantation (FMT) as a treatment modality, British Association of Urological Surgeons Annual Scientific Meeting, Publisher: SAGE Publications, Pages: 83-85, ISSN: 2051-4158

Conference paper

Ming DK, Otter JA, Ghani R, Brannigan ET, Boonyasiri A, Mookerjee S, Gilchrist M, Holmes AH, Davies Fet al., 2019, Clinical risk stratification and antibiotic management of NDM and OXA-48 carbapenemase-producing Enterobacteriaceae bloodstream infections in the UK, Journal of Hospital Infection, Vol: 102, Pages: 95-97, ISSN: 0195-6701

Journal article

Ghani R, Gan C, Mullish B, Ferizoli V, Thursz M, Marchesi J, Davies F, Dasgupta R, Minhas Set al., 2019, MP71-15 Prevalence of recurrent extended-spectrum beta-lactamase (ESBL) urinary tract infections (UTIs) in patients within a urology service. Introducing the concept of Faecal Microbiota transplantation (FMT) as a treatment modality., AUA 2019, Publisher: Elsevier, ISSN: 0022-5347

Conference paper

Ghani R, Gan C, Mullish B, Ferizoli V, Davies F, Thursz M, Marchesi J, Dasgupta R, Minhas Set al., 2019, Prevalence of recurrent extended-spectrum beta-lactamase (ESBL) urinary tract infections (UTIs) in patients within a urology service. Introducing the concept of Faecal Microbiota transplantation (FMT) as a treatment modality., Journal of Clinical Urology

Journal article

Ghani R, 2019, 27: Skin and Soft Tissue Infections, Tutorial Topics in Infection for the Combined Infection Training Programme, Publisher: Oxford University Press, USA, ISBN: 9780198801740

Tutorial Topics in Infection for the Combined Infection Training Programme is the first book covering the complete CIT curriculum.

Book chapter

Ghani R, 2019, 28: Bone and Joint Infections, Tutorial Topics in Infection for the Combined Infection Training Programme, Publisher: Oxford University Press, USA, ISBN: 9780198801740

Tutorial Topics in Infection for the Combined Infection Training Programme is the first book covering the complete CIT curriculum.

Book chapter

Jewell P, Dixon L, Singanayagam A, Ghani R, Wong E, Coleman M, Pichon B, Kearns A, Russell G, Hatcher Jet al., 2019, Severe disseminated infection with emerging lineage of methicillin-sensitive staphylococcus aureus, Emerging Infectious Diseases, Vol: 25, Pages: 187-189, ISSN: 1080-6040

We report a case of severe disseminated infection in an immunocompetent man caused by an emerging lineage of methicillin-sensitive Staphylococcus aureus clonal complex 398. Genes encoding classic virulence factors were absent. The patient made a slow recovery after multiple surgical interventions and a protracted course of intravenous flucloxacillin.

Journal article

Ghani R, Gan C, Mullish B, Ferizoli V, Davies F, Thursz M, Marchesi J, Dasgupta R, minhas Set al., 2018, Prevalence of recurrent extended-spectrum beta-lactamase (ESBL) urinary tract infections (UTIs) in patients within a urology service. Introducing the concept of Faecal Microbiota transplantation (FMT) as a treatment modality., Annual EAU Congress, Publisher: Elsevier, Pages: e375-e376, ISSN: 1569-9056

Conference paper

Ghani R, Mookerjee S, Mullish BH, Thursz M, Marchesi J, Pavlu J, Davies Fet al., 2018, Impact on Length of Stay and Antibiotic Use in Allogenic and Autologous Stem Cell Transplant Patients Colonized with Carbapenemase-producing Enterobacteriaceae, IDWeek, Publisher: Oxford University Press, ISSN: 2328-8957

Conference paper

Janmohamed A, Abbara A, Ghani R, Kinderlerer A, Sritharan T, Hatcher Jet al., 2018, Pneumomediastinum complicating adult-onset measles, CLINICAL MEDICINE, Vol: 18, Pages: 403-405, ISSN: 1470-2118

Journal article

Abbara A, Chitty S, Roe JK, Ghani R, Collin SM, Ritchie A, Kon OM, Dzvova J, Davidson H, Edwards TE, Hateley C, Routledge M, Buckley J, Davidson RN, John Let al., 2017, Drug-induced liver injury from antituberculous treatment: a retrospective study from a large TB centre in the UK, BMC INFECTIOUS DISEASES, Vol: 17, ISSN: 1471-2334

Journal article

Avery K, Abbara A, Ghani R, Davidson RNet al., 2015, Recurrent tuberculosis at a large tuberculosis centre in the UK, JOURNAL OF INFECTION, Vol: 70, Pages: 427-429, ISSN: 0163-4453

Journal article

Chitty S, Ghani R, Abbara A, Roe JK, Davidson H, Routledge M, Edwards T, Hateley C, Collin S, Ritchie A, Dzvova J, Buckley J, Davidson RN, John Let al., 2014, P190 Drug Induced Liver Injury In The Treatment Of Tuberculosis In A Busy Uk Centre (vol 69, pg A159, 2014), THORAX, Vol: 69, Pages: 301-301, ISSN: 0040-6376

Journal article

Chitty S, Ghani R, Roe JK, Davidson H, Routledge M, Edwards T, Hateley C, Collin S, Ritchie A, Dzvova J, Buckley J, Davidson RN, John Let al., 2014, DRUG INDUCED LIVER INJURY IN THE TREATMENT OF TUBERCULOSIS IN A BUSY UK CENTRE, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A159-A159, ISSN: 0040-6376

Conference paper

Avery K, Ghani R, Buckley J, John L, Davidson RNet al., 2014, RECURRENT TUBERCULOSIS AND ITS RISK FACTORS IN THE UK'S LARGEST TB CENTRE, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A210-A211, ISSN: 0040-6376

Conference paper

Ghani R, Durkan H, John L, Davidson R, Buckley Jet al., 2014, SCREENING FOR TUBERCULOMAS IN PATIENTS WITH MILIARY TUBERCULOSIS - WHAT MODALITY OF IMAGING SHOULD WE BE USING?, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A210-A210, ISSN: 0040-6376

Conference paper

Shah N, Young S, Ghani R, John L, Davidson RNet al., 2014, Reversing the tide of the UK tuberculosis epidemic, LANCET, Vol: 383, Pages: 215-215, ISSN: 0140-6736

Journal article

Patel K, Ghani R, Hartley A, O'Connell Ret al., 2012, Breast feeding in HIV: assessing risks in a London clinic, Publisher: JOHN WILEY & SONS LTD, Pages: 115-115

Conference paper

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