Imperial College London
Alternate

ProfessorRobertGlen

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Computational Medicine
 
 
 
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Contact

 

+44 (0)20 7594 7912r.glen Website

 
 
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Location

 

362Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ashrafian:2020:10.1159/000513545,
author = {Ashrafian, H and Sounderajah, V and Glen, R and Ebbels, T and Blaise, BJ and Kalra, D and Kultima, K and Spjuth, O and Tenori, L and Salek, R and Kale, N and Haug, K and Schober, D and Rocca-Serra, P and O'Donovan, C and Steinbeck, C and Cano, I and de, Atauri P and Cascante, M},
doi = {10.1159/000513545},
journal = {Medical Principles and Practice},
pages = {301--310},
title = {Metabolomics - the stethoscope for the 21st century},
url = {http://dx.doi.org/10.1159/000513545},
volume = {30},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Metabolomics offers systematic identification and quantification of all metabolic products from the human body. This field could provide clinicians with new sets of diagnostic biomarkers for disease states in addition to quantifying treatment response to medications at an individualised level. This literature review aims to highlight the technology underpinning metabolic profiling, identify potential applications of metabolomics in clinical practice and discuss the translational challenges that the field faces. We searched PubMed, Medline and Embase for primary and secondary research articles regarding clinical applications of metabolomics. Metabolic profiling can be performed using mass spectrometry and NMR based techniques using a variety of biological samples. This is carried out in vivo or in vitro following careful sample collection, preparation and analysis. The potential clinical applications constitute disruptive innovations in their respective specialities, particularly oncology and metabolic medicine. Outstanding issues currently preventing widespread clinical use centre around scalability of data interpretation, standardisation of sample handling practice and e-infrastructure. Routine utilisation of metabolomics at a patient and population level will constitute an integral part of future healthcare provision.
AU  - Ashrafian,H
AU  - Sounderajah,V
AU  - Glen,R
AU  - Ebbels,T
AU  - Blaise,BJ
AU  - Kalra,D
AU  - Kultima,K
AU  - Spjuth,O
AU  - Tenori,L
AU  - Salek,R
AU  - Kale,N
AU  - Haug,K
AU  - Schober,D
AU  - Rocca-Serra,P
AU  - O'Donovan,C
AU  - Steinbeck,C
AU  - Cano,I
AU  - de,Atauri P
AU  - Cascante,M
DO  - 10.1159/000513545
EP  - 310
PY  - 2020///
SN  - 1011-7571
SP  - 301
TI  - Metabolomics - the stethoscope for the 21st century
T2  - Medical Principles and Practice
UR  - http://dx.doi.org/10.1159/000513545
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33271569
UR  - https://www.karger.com/Article/Abstract/513545#
UR  - http://hdl.handle.net/10044/1/86807
VL  - 30
ER  -
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