Summary
CURRENT RESEARCH ACTIVITIES
I am a histopathologist specialising in gastro-intestinal and liver disease and am involved in clinical work, teaching and research. I am based at Imperial but also work at the Ludwig Insitute for Cancer Research, University of Oxford with Professor Xin Lu.
At Imperial, my major research collaborations are with Profesor Hanna (upper GI), Professor Mark Thursz (liver) and Professor Zoltan Takats (metabonomics).
Overall, my main interest is in developing new techniques for extracting information from tissue samples including using, mainly, metabanomic and digital pathology approaches. This also involves the phenotyping of mouse models of liver disease.
Selected Publications
Journal Articles
Eyres M, Lanfredini S, Xu H, et al., 2021, TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes, Gastroenterology, Vol:161, ISSN:0016-5085, Pages:653-668.e16
Alexander J, Gildea L, Balog J, et al., 2016, A novel methodology for in vivo endoscopic phenotyping of colorectal cancer based on real-time analysis of the mucosal lipidome: a prospective observational study of the iKnife, Surgical Endoscopy and Other Interventional Techniques, Vol:31, ISSN:1432-2218, Pages:1361-1370
Abbassi-Ghadi N, Jones EA, Gomez-Romero M, et al., 2015, A Comparison of DESI-MS and LC-MS for the Lipidomic Profiling of Human Cancer Tissue, Journal of the American Society for Mass Spectrometry, Vol:27, ISSN:1044-0305, Pages:255-264
Zauri M, Berridge G, Thezenas M-L, et al., 2015, CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer, Nature, Vol:524, ISSN:0028-0836, Pages:114-118
Antoniades C, 2013, Secretory Leukocyte Protease Inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen induced acute liver failure, Hepatology
Wang XD, Lapi E, Sullivan A, et al., 2011, SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence, Cell Death and Differentiation, Vol:18, ISSN:1350-9047, Pages:304-314
Anstee QM, Concas D, Kudo H, et al., 2010, Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis, Journal of Hepatology, Vol:53, ISSN:0168-8278, Pages:542-550
Levene AP, Kudo H, Thursz MR, et al., 2010, Is Oil Red-O Staining and Digital Image Analysis the Gold Standard for Quantifying Steatosis in the Liver?, Hepatology, Vol:51, ISSN:0270-9139, Pages:1859-1859
Levene AP, Goldin RD, 2010, Physiological hepatic nuclear vacuolation-how long does it persist?, Histopathology, Vol:56, ISSN:0309-0167, Pages:426-429
Conference
Alazawi W, Heath H, Petts G, et al., 2015, STAT2 IS A KEY INFLAMMATORY MOLECULE IN HUMAN NON-ALCOHOLIC FATTY LIVER DISEASE AND MURINE LIVER INJURY, 2nd Digestive-Disorders-Federation Conference, BMJ PUBLISHING GROUP, Pages:A452-A453, ISSN:0017-5749