Imperial College London
Alternate

ProfessorRogerGunn

Faculty of Medicine, Department of Brain Sciences

Emeritus Professor of Molecular Neuroimaging
 
 
 
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Contact

 

r.gunn

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Syvänen:2022:10.1007/978-3-030-88773-5_11,
author = {Syvänen, S and Gunn, RN and Zhang, L},
booktitle = {AAPS Advances in the Pharmaceutical Sciences Series},
doi = {10.1007/978-3-030-88773-5_11},
pages = {329--352},
title = {Principles of PET and Its Role in Understanding Drug Delivery to the Brain},
url = {http://dx.doi.org/10.1007/978-3-030-88773-5_11},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Positron emission tomography (PET) is a noninvasive medical imaging technique that enables the investigation of drug pharmacokinetics in vivo. The technique is especially powerful for pharmacokinetic studies of new CNS drug candidates as tissue samples from the brain are understandably difficult to obtain. The PET technique involves the administration of a radiolabeled molecule, often referred to as a PET radiotracer, whose spatiotemporal distribution can be measured using tomography. The radiolabeled molecule can be the drug under investigation, a structurally different molecule that binds to the same target as the drug candidate, or a molecule that interacts with a downstream target that is believed to be affected by the action of the drug candidate. Such radiolabeled probes allow PET to address several questions central for CNS drug development: Does the drug candidate reach the target site? Does the drug candidate interact with the desired target? Is the concentration of the drug at the target site sufficient to illicit an effect? What is the temporal nature of such an interaction? What is the relationship between the target site concentration and the administered dose and/or plasma concentrations?.
AU  - Syvänen,S
AU  - Gunn,RN
AU  - Zhang,L
DO  - 10.1007/978-3-030-88773-5_11
EP  - 352
PY  - 2022///
SP  - 329
TI  - Principles of PET and Its Role in Understanding Drug Delivery to the Brain
T1  - AAPS Advances in the Pharmaceutical Sciences Series
UR  - http://dx.doi.org/10.1007/978-3-030-88773-5_11
ER  -
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