Imperial College London
Alternate

Dr Roya E Haghighat-Khah

Faculty of Natural Sciences, Department of Life Sciences

Honorary Research Associate
 
 
 
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Contact

 

r.haghighat-khah

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Alcalay:2019:10.1101/860551,
author = {Alcalay, Y and Fuchs, S and Galizi, R and Bernardini, F and Haghighat-Khah, RE and Rusch, DB and Adrion, JR and Hahn, MW and Tortosa, P and Papathanos, PA},
doi = {10.1101/860551},
title = {The potential for a released autosomal X-shredder becoming a driving-Y chromosome and invasively suppressing wild populations of malaria mosquitoes},
url = {http://dx.doi.org/10.1101/860551},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Synthetic sex-ratio distorters based on X-chromosome shredding are predicted to be more efficient than sterile males for population suppression of malaria mosquitoes using genetic control. X-chromosome shredding operates through the targeted elimination of X-chromosome-bearing gametes during male spermatogenesis, resulting in males that have a high fraction of male offspring. Strains harboring autosomal constructs containing a modified endonuclease I-<jats:italic>Ppo</jats:italic>I have now been developed in the malaria mosquito <jats:italic>Anopheles gambiae</jats:italic>, resulting in strong sex-ratio distortion towards males. Data are being gathered for these strains for submission of regulatory dossiers for contained use and subsequent field release in West Africa. Since autosomal X-shredders are transmitted in a Mendelian fashion and can be selected against their frequency in the population is expected to decline once releases are halted. However, any unintended transfer of the X-shredder to the Y-chromosome could theoretically change these dynamics: This could lead to 100% transmission of the newly Y-linked X-shredder to the predominant male-biased offspring and its insulation from negative selection in females, resulting in its potential spread in the population and ultimately to suppression. Here, we analyze plausible mechanisms whereby an autosomal X-shredder could become linked to the Y-chromosome after release and provide data regarding its potential for activity should it become linked to the Y-chromosome. Our results strongly suggest that Y-chromosome linkage through remobilization of the transposon used for the initial genetic transformation is unlikely, and that, in the unexpected event that the X-shredder becomes linked to the Y-chromosome, expression and activity of the X-shredder would likely be inhibited by meiotic sex chromosome inactivation. We conclude that a fun
AU  - Alcalay,Y
AU  - Fuchs,S
AU  - Galizi,R
AU  - Bernardini,F
AU  - Haghighat-Khah,RE
AU  - Rusch,DB
AU  - Adrion,JR
AU  - Hahn,MW
AU  - Tortosa,P
AU  - Papathanos,PA
DO  - 10.1101/860551
PY  - 2019///
TI  - The potential for a released autosomal X-shredder becoming a driving-Y chromosome and invasively suppressing wild populations of malaria mosquitoes
UR  - http://dx.doi.org/10.1101/860551
ER  -
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