Publications
520 results found
Wilkinson KA, Kon OM, Newton SM, et al., 2006, Effect of treatment of latent tuberculosis infection on the T cell response to <i>Mycobacterium tuberculosis</i> antigens, JOURNAL OF INFECTIOUS DISEASES, Vol: 193, Pages: 354-359, ISSN: 0022-1899
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- Citations: 94
Wilkinson RJ, Levin M, 2006, Host Genetics and Susceptibility to infection, Tropical Infectious Diseases: Principles, pathogens and practice, Editors: Guerrant, Walker D, Weller P, Philadelphia, Publisher: Churchill Livingstone, Pages: 53-67, ISBN: 9780443066689
Wilkinson RJ, Levin M, Pasvol G, 2005, Host Genetics and Susceptibility to Infection, Tropical Infectious Diseases: Principles, Pathogens, & Practice, 2-Volume Set with CD-ROM, Pages: 53-67, ISBN: 9780702036033
Martineau AR, Hall BM, Newton SM, et al., 2005, Vitamin D enhances antimycobacterial immunity in vivo and in vitro, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: II43-II44, ISSN: 0040-6376
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- Citations: 2
Nicol MP, Sola C, February B, et al., 2005, Distribution of strain families of <i>Mycobacterium tuberculosis</i> causing pulmonary and extrapulmonary disease in hospitalized children in Cape Town, South Africa, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 43, Pages: 5779-5781, ISSN: 0095-1137
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- Citations: 56
Stewart GR, Wilkinson KA, Newton SA, et al., 2005, Effect of deletion or overexpression of the 19-kilodalton lipoprotein Rv3763 on the innate response to <i>Mycobacterium tuberculosis</i>, INFECTION AND IMMUNITY, Vol: 73, Pages: 6831-6837, ISSN: 0019-9567
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- Citations: 32
Vidal CG, Garau J, 2005, Systemic steroid treatment of paradoxical upgrading reaction in patients with lymph node tuberculosis, CLINICAL INFECTIOUS DISEASES, Vol: 41, Pages: 915-916, ISSN: 1058-4838
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- Citations: 15
Wilkinson RJ, Hawkey CR, Davidson RN, 2005, Systemic steroid treatment of paradoxical upgrading reaction in patients with lymph node tuberculosis - Reply, CLINICAL INFECTIOUS DISEASES, Vol: 41, Pages: 916-917, ISSN: 1058-4838
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- Citations: 3
Kaushik N, Fear D, Richards SCM, et al., 2005, Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome, JOURNAL OF CLINICAL PATHOLOGY, Vol: 58, Pages: 826-832, ISSN: 0021-9746
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- Citations: 104
Ustianowski A, Shaffer R, Collin S, et al., 2005, Prevalence and associations of vitamin D deficiency in foreign-born persons with tuberculosis in London, JOURNAL OF INFECTION, Vol: 50, Pages: 432-437, ISSN: 0163-4453
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- Citations: 118
Hawkey CR, Yap T, Pereira J, et al., 2005, Characterization and management of paradoxical upgrading reactions in HIV-uninfected patients with lymph node tuberculosis, CLINICAL INFECTIOUS DISEASES, Vol: 40, Pages: 1368-1371, ISSN: 1058-4838
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- Citations: 116
Nicol MP, Pienaar D, Wood K, et al., 2005, Enzyme-linked immunospot assay responses to early secretory antigenic target 6, culture filtrate protein 10, and purified protein derivative among children with tuberculosis: Implications for diagnosis and monitoring of therapy, CLINICAL INFECTIOUS DISEASES, Vol: 40, Pages: 1301-1308, ISSN: 1058-4838
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- Citations: 98
Wilkinson KA, Simsova M, Schölvinck E, et al., 2005, Efficient ex vivo stimulation of <i>Mycobacterium tuberculosis</i>-specific T cells by genetically detoxified <i>Bordetella pertussis</i> adenylate cyclase antigen toxoids, INFECTION AND IMMUNITY, Vol: 73, Pages: 2991-2998, ISSN: 0019-9567
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- Citations: 15
Wilkinson KA, Stewart GR, Newton SM, et al., 2005, Infection biology of a novel α-crystallin of <i>Mycobacterium tuberculosis</i>:: Acr2, JOURNAL OF IMMUNOLOGY, Vol: 174, Pages: 4237-4243, ISSN: 0022-1767
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- Citations: 53
Wilkinson RJ, Lockwood DNJ, 2005, Antigenic trigger for type 1 reaction in leprosy, JOURNAL OF INFECTION, Vol: 50, Pages: 242-243, ISSN: 0163-4453
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- Citations: 4
Stewart GR, Newton SM, Wilkinson KA, et al., 2005, The stress-responsive chaperone α-crystallin 2 is required for pathogenesis of <i>Mycobacterium tuberculosis</i>, MOLECULAR MICROBIOLOGY, Vol: 55, Pages: 1127-1137, ISSN: 0950-382X
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- Citations: 69
Wilkinson KA, Wilkinson RJ, Pathan A, et al., 2005, Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis, CLINICAL INFECTIOUS DISEASES, Vol: 40, Pages: 184-187, ISSN: 1058-4838
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- Citations: 140
Kampmann B, Hemingway C, Stephens A, et al., 2005, Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma., Journal of Clinical Investigation, Vol: 115, Pages: 2480-2488
Vordermeier HM, Simsova M, Wilkinson KA, et al., 2004, Recognition of mycobacterial antigens delivered by genetically detoxified <i>Bordetella pertussis</i> adenylate cyclase by T cells from cattle with bovine tuberculosis, INFECTION AND IMMUNITY, Vol: 72, Pages: 6255-6261, ISSN: 0019-9567
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- Citations: 13
Wilkinson RJ, DesJardin LE, Islam N, et al., 2004, An increase in expression of a <i>Mycobacterium tuberculosis</i> mycolyl transferase gene (<i>fbpB</i>) occurs early after infection of human monocytes (vol 39, pg 813, 2001), MOLECULAR MICROBIOLOGY, Vol: 53, Pages: 1001-1001, ISSN: 0950-382X
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- Citations: 1
Islam N, Kanost AR, Teixeira L, et al., 2004, Role of cellular activation and tumor necrosis factor-αα in the early expression of <i>Mycobacterium tuberculosis</i> 85B mRNA in human alveolar macrophages, JOURNAL OF INFECTIOUS DISEASES, Vol: 190, Pages: 341-351, ISSN: 0022-1899
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- Citations: 22
Scholvinck E, Wilkinson KA, Whelan AO, et al., 2004, Gamma interferon-based immunodiagnosis of tuberculosis: comparison between whole-blood and enzyme-linked immunospot methods.], J Clin Microbiol, Pages: 829-831
Eddleston M, Davidson RN, Wilkinson RJ, et al., 2004, Oxford handbook of tropical medicine, Publisher: Oxford University Press, ISBN: 9780198525097
Wilkinson RJ, 2004, Novel Vaccines Against Tuberculosis, New Generation Vaccines, Editors: Levine, Kaper, Rappuoli, Liu, Good, New York, Publisher: Marcel Dekker, Pages: 519-535
Cabalo E, Wilkinson R, Lu NT, et al., 2002, Molecular analysis and pathology of a second pediatric HIV-associated Burkitt lymphoma, PEDIATRIC PATHOLOGY & MOLECULAR MEDICINE, Vol: 21, Pages: 525-530, ISSN: 1522-7952
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- Citations: 1
Chua-Intra B, Wilkinson RJ, Ivanyi J, 2002, Selective T-Cell recognition of the N-terminal peptide of GroES in tuberculosis, INFECTION AND IMMUNITY, Vol: 70, Pages: 1645-1647, ISSN: 0019-9567
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- Citations: 6
Canaday DH, Wilkinson RJ, Li Q, et al., 2001, CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T cells kill intracellular <i>Mycobacterium tuberculosis</i> by a perforin and Fas/Fas ligand-independent mechanism, JOURNAL OF IMMUNOLOGY, Vol: 167, Pages: 2734-2742, ISSN: 0022-1767
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- Citations: 156
Lalvani A, Pathan AA, McShane H, et al., 2001, Rapid detection of <i>Mycobacterium tuberculosis</i> infection by enumeration of antigen-specific T cells, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 163, Pages: 824-828, ISSN: 1073-449X
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- Citations: 373
Wilkinson RJ, DesJardin LE, Islam N, et al., 2001, An increase in expression of a <i>Mycobacterium tuberculosis</i> mycolyl transferase gene (<i>fbpB</i>) occurs early after infection of human monocytes, MOLECULAR MICROBIOLOGY, Vol: 39, Pages: 813-821, ISSN: 0950-382X
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- Citations: 44
Pathan AA, Wilkinson KA, Wilkinson RJ, et al., 2000, High frequencies of circulating IFN-γ-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease, European Journal of Immunology, Vol: 30, Pages: 2713-2721, ISSN: 0014-2980
MHC class I-restricted CD8 cytotoxic T lymphocytes (CTL) are essential for protective immunity to Mycobacterium tuberculosis in animal models but their role in humans remains unclear. We therefore studied subjects who had successfully contained M. tuberculosis infection in vivo, i.e. exposed healthy household contacts and individuals with inactive self-healed pulmonary tuberculosis. Using the ELISPOT assay for IFN-γ, we screened peptides from ESAT-6, a secreted antigen that is highly specific for M. tuberculosis. We identified a novel nonamer epitope: unstimulated peripheral blood-derived CD8 T cells displayed peptide-specific IFN-γ release ex vivo while CD8 T cell lines and clones exhibited HLA-A68.02-restricted cytolytic activity and recognized endogenously processed antigen. The frequency of CD8 CTL specific for this single M. tuberculosis epitope, 1/2500 peripheral blood lymphocytes, was equivalent to the combined frequency of all IFN-γ-secreting purified protein derivative-reactive T cells ex vivo. This highly focused CTL response was maintained in an asymptomatic contact over 2 years and is the most potent antigen-specific anti-mycobacterial CD8 CTL response hitherto described. Thus, human M. tuberculosis-specific CD8 CTL are not necessarily associated with active disease per se. Rather, our results are consistent with a protective role for these ESAT-6-specific CD8 T cells in the long-term control of M. tuberculosis in vivo in humans.
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