Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lesosky:2019:cid/ciy823,
author = {Lesosky, M and Rangaka, MX and Pienaar, C and Coussens, AK and Goliath, RT and Mathee, S and Mwansa-Kambafwile, J and Maartens, G and Wilkinson, RJ and Wilkinson, KA},
doi = {cid/ciy823},
journal = {Clinical Infectious Diseases},
pages = {295--305},
title = {Plasma Biomarkers to Detect Prevalent or Predict Progressive Tuberculosis Associated With Human Immunodeficiency Virus–1},
url = {http://dx.doi.org/10.1093/cid/ciy823},
volume = {69},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe risk of HIV-1 infected individuals developing TB is high while both prognostic and diagnostic tools remain insensitive. The predictive performance of plasma biomarkers to identify HIV-1 infected individuals likely to progress to active disease is unknown.MethodsThirteen preselected analytes were determined from QuantiFERON® Gold in-tube (QFT) plasma samples in 421 HIV-1 infected persons recruited within the screening and enrolment phases of a randomised controlled trial of isoniazid preventive therapy. Blood for QFT was obtained pre-randomisation. Individuals were classified into prevalent TB, incident TB and controls. Comparisons between groups, supervised learning methods and weighted correlation network analyses were applied utilising the unstimulated and background-corrected plasma analyte concentrations.ResultsUnstimulated samples showed higher analyte concentrations in prevalent and incident TB compared to controls. The largest differences were seen for CXCL10, IL-2, IL-1 and TGF-. Predictive model analysis using unstimulated analytes discriminated better between controls and prevalent TB (Area Under the Curve AUC= 0·9), reasonably between incident and prevalent TB (AUC > 0·8), but poorly between controls and incident TB. Unstimulated IL-2 and IFN-γ were ranked at or near the top for all comparisons except the comparison between controls vs incident TB. Models using background adjusted values performed poorly.ConclusionsSingle plasma biomarkers are unlikely to distinguish between disease states in HIV-1 co-infected individuals and combinations of biomarkers are required. The ability to detect prevalent TB is potentially important, as no blood test hitherto has suggested utility to detect prevalent TB amongst HIV-1 co-infected persons.
AU  - Lesosky,M
AU  - Rangaka,MX
AU  - Pienaar,C
AU  - Coussens,AK
AU  - Goliath,RT
AU  - Mathee,S
AU  - Mwansa-Kambafwile,J
AU  - Maartens,G
AU  - Wilkinson,RJ
AU  - Wilkinson,KA
DO  - cid/ciy823
EP  - 305
PY  - 2019///
SN  - 1058-4838
SP  - 295
TI  - Plasma Biomarkers to Detect Prevalent or Predict Progressive Tuberculosis Associated With Human Immunodeficiency Virus–1
T2  - Clinical Infectious Diseases
UR  - http://dx.doi.org/10.1093/cid/ciy823
UR  - http://hdl.handle.net/10044/1/64941
VL  - 69
ER  -
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