Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Riou:2020:infdis/jiz417,
author = {Riou, CR and Jhilmeet, N and Rangaka, MX and Wilkinson, RJ and Wilkinson, KA},
doi = {infdis/jiz417},
journal = {Journal of Infectious Diseases},
pages = {162--167},
title = {Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment},
url = {http://dx.doi.org/10.1093/infdis/jiz417},
volume = {221},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The reconstitution of Mycobacterium tuberculosis (Mtb)-antigen-specific CD4 T cells in a cohort of HIV-infected persons starting antiretroviral treatment (ART) in high TB endemic area is described. Restoration of the antigen-specific CD4 T cell subsets mirrored the overall CD4 T cell compartment. Activation (assessed by HLA-DR expression) decreased during ART but remained elevated compared to HIV-uninfected persons. Despite known Mtb sensitisation determined by IGRA, 12/23 participants had no Mtb-specific CD4 T cells detectable by flow cytometry, combined with overall elevated T cell activation and memory differentiation, suggesting heightened turnover. Our data suggest early ART initiation to maintain polyfunctional immune memory responses.
AU  - Riou,CR
AU  - Jhilmeet,N
AU  - Rangaka,MX
AU  - Wilkinson,RJ
AU  - Wilkinson,KA
DO  - infdis/jiz417
EP  - 167
PY  - 2020///
SN  - 0022-1899
SP  - 162
TI  - Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment
T2  - Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1093/infdis/jiz417
UR  - https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiz417/5550849
UR  - http://hdl.handle.net/10044/1/72790
VL  - 221
ER  -
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