Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Middelkoop:2022:10.3390/nu14061263,
author = {Middelkoop, K and Walker, N and Stewart, J and Delport, C and Joliffe, DA and Nuttall, J and Coussens, AK and Naude, CE and Tang, JCY and Fraser, WD and Wilkinson, RJ and Bekker, L-G and Martineau, AR},
doi = {10.3390/nu14061263},
journal = {Nutrients},
pages = {1--13},
title = {Prevalence and determinants of vitamin D deficiency in 1,825 Cape Town primary schoolchildren: a cross-sectional study},
url = {http://dx.doi.org/10.3390/nu14061263},
volume = {14},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Vitamin D deficiency (25-hydroxyvitamin D[25(OH)D] <50 nmol/L) is common among adults in Cape Town, South Africa, but studies investigating vitamin D status of children in this setting are lacking. We conducted a cross-sectional study to determine the prevalence and determinants of vitamin D deficiency in 1825 Cape Town schoolchildren aged 6–11 years. Prevalence of vitamin D deficiency was 7.6% (95% Confidence Interval [CI] 6.5% to 8.9%). Determinants of vitamin D deficiency included month of sampling (adjusted odds ratio [aOR] for July–September vs. January–March 10.69, 95% CI 5.02 to 22.77; aOR for October–December vs. January–March 6.73, 95% CI 2.82 to 16.08), older age (aOR 1.25 per increasing year, 95% CI: 1.01–1.53) and higher body mass index (BMI; aOR 1.24 per unit increase in BMI-for-age Z-score, 95% CI: 1.03–1.49). In a subset of 370 participants in whom parathyroid hormone (PTH) concentrations were measured; these were inversely related to serum 25(OH)D concentrations (p < 0.001). However, no association between participants with hyperparathyroidism (PTH >6.9 pmol/L) and vitamin D deficiency was seen (p = 0.42). In conclusion, we report that season is the major determinant of vitamin D status among Cape Town primary schoolchildren, with prevalence of vitamin D deficiency ranging from 1.4% in January–March to 22.8% in July–September.
AU  - Middelkoop,K
AU  - Walker,N
AU  - Stewart,J
AU  - Delport,C
AU  - Joliffe,DA
AU  - Nuttall,J
AU  - Coussens,AK
AU  - Naude,CE
AU  - Tang,JCY
AU  - Fraser,WD
AU  - Wilkinson,RJ
AU  - Bekker,L-G
AU  - Martineau,AR
DO  - 10.3390/nu14061263
EP  - 13
PY  - 2022///
SN  - 2072-6643
SP  - 1
TI  - Prevalence and determinants of vitamin D deficiency in 1,825 Cape Town primary schoolchildren: a cross-sectional study
T2  - Nutrients
UR  - http://dx.doi.org/10.3390/nu14061263
UR  - https://www.mdpi.com/2072-6643/14/6/1263
UR  - http://hdl.handle.net/10044/1/95822
VL  - 14
ER  -
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