Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
//

Contact

 

r.j.wilkinson Website

 
 
//

Location

 

Commonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Mbandi:2022:10.1002/eji.202249815,
author = {Mbandi, SK and Painter, H and Penn-Nicholson, A and Toefy, A and Erasmus, M and Hanekom, WA and Scriba, TJ and Lai, RPJ and Marais, S and Fletcher, HA and Meintjes, G and Wilkinson, RJ and Cotton, MF and Pahwa, S and Cameron, MJ and Nemes, E},
doi = {10.1002/eji.202249815},
journal = {European Journal of Immunology},
pages = {1112--1119},
title = {Host transcriptomic signatures of tuberculosis can predict immune reconstitution inflammatory syndrome in HIV patients},
url = {http://dx.doi.org/10.1002/eji.202249815},
volume = {52},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Immune reconstitution inflammatory syndrome (IRIS) can be a complication of antiretroviral therapy (ART) in patients with advanced HIV, but its pathogenesis is uncertain. In tuberculosis (TB) endemic countries, IRIS is often associated with mycobacterial infections or Bacille-Calmette-Guerin (BCG) vaccination in children. With no predictive or confirmatory tests at present, IRIS remains a diagnosis of exclusion.We tested whether RISK6 and Sweeney3, validated immune-based blood transcriptomic signatures for TB, could predict or diagnose IRIS in HIV+ children and adults.Transcripts were measured by RT-qPCR in BCG-vaccinated children and by microarray in HIV+ adults with TB including TB meningitis (TBM). Signature scores before ART initiation and up to IRIS diagnosis were compared between participants who did or did not develop IRIS.In children, RISK6 and Sweeney3 discriminated IRIS cases from non-IRIS controls before ART, and at diagnosis. In adults with TB, RISK6 discriminated IRIS cases from controls after half-week on ART and at TB-IRIS onset. In adults with TBM, only Sweeney3 discriminated IRIS cases from controls before ART, while both signatures distinguished cases from controls at TB-IRIS onset.Parsimonious whole blood transcriptomic signatures for TB showed potential to predict and diagnose IRIS in HIV+ children and adults.
AU  - Mbandi,SK
AU  - Painter,H
AU  - Penn-Nicholson,A
AU  - Toefy,A
AU  - Erasmus,M
AU  - Hanekom,WA
AU  - Scriba,TJ
AU  - Lai,RPJ
AU  - Marais,S
AU  - Fletcher,HA
AU  - Meintjes,G
AU  - Wilkinson,RJ
AU  - Cotton,MF
AU  - Pahwa,S
AU  - Cameron,MJ
AU  - Nemes,E
DO  - 10.1002/eji.202249815
EP  - 1119
PY  - 2022///
SN  - 0014-2980
SP  - 1112
TI  - Host transcriptomic signatures of tuberculosis can predict immune reconstitution inflammatory syndrome in HIV patients
T2  - European Journal of Immunology
UR  - http://dx.doi.org/10.1002/eji.202249815
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000795986100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1002/eji.202249815
UR  - http://hdl.handle.net/10044/1/100301
VL  - 52
ER  -
Download