Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ariza-Vioque:2022:10.1007/s40121-022-00667-z,
author = {Ariza-Vioque, E and Ello, F and Andriamamonjisoa, H and Machault, V and González-Martín, J and Calvo-Cortés, MC and Eholié, S and Tchabert, GA and Ouassa, T and Raberahona, M and Rakotoarivelo, R and Razafindrakoto, H and Rahajamanana, L and Wilkinson, RJ and Davis, A and Maxebengula, M and Abrahams, F and Muzoora, C and Nakigozi, N and Nyehangane, D and Nanjebe, D and Mbega, H and Kaitano, R and Bonnet, M and Debeaudrap, P and Miró, JM and Anglaret, X and Rakotosamimanana, N and Calmy, A and Bonnet, F and Ambrosioni, J and INTENSE-TBM, Group},
doi = {10.1007/s40121-022-00667-z},
journal = {Infectious Diseases and Therapy},
pages = {1327--1341},
title = {Capacity building in Sub-Saharan Africa as part of the INTENSE-TBM Project during the COVID-19 pandemic},
url = {http://dx.doi.org/10.1007/s40121-022-00667-z},
volume = {11},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), with at least 100,000 cases per year and a mortality rate of up to 50% in individuals co-infected with human immunodeficiency virus type 1 (HIV-1). To evaluate the efficacy and safety of an intensified anti-tubercular regimen and an anti-inflammatory treatment, the INTENSE-TBM project includes a phase III randomised clinical trial (TBM-RCT) in four countries in sub-Saharan Africa (SSA). Within this framework, we designed a comprehensive capacity-building work package ensuring all centres had, or would acquire, the ability to conduct the TBM-RCT and developing a network of skilled researchers, clinical centres and microbiology laboratories. Here, we describe these activities, identify strengths/challenges and share tools adaptable to other projects, particularly in low- and lower-middle income countries with heterogeneous settings and during the coronavirus disease 2019 (COVID-19) pandemic. Despite major challenges, TBM-RCT initiation was achieved in all sites, promoting enhanced local healthcare systems and encouraging further clinical research in SSA. In terms of certified trainings, the achievement levels were 95% (124/131) for good clinical practice, 91% (39/43) for good clinical laboratory practice and 91% (48/53) for infection prevention and control. Platform-based research, developed as part of capacity-building activities for specific projects, may be a valuable tool in fighting future infectious diseases and in developing high-level research in Africa.
AU  - Ariza-Vioque,E
AU  - Ello,F
AU  - Andriamamonjisoa,H
AU  - Machault,V
AU  - González-Martín,J
AU  - Calvo-Cortés,MC
AU  - Eholié,S
AU  - Tchabert,GA
AU  - Ouassa,T
AU  - Raberahona,M
AU  - Rakotoarivelo,R
AU  - Razafindrakoto,H
AU  - Rahajamanana,L
AU  - Wilkinson,RJ
AU  - Davis,A
AU  - Maxebengula,M
AU  - Abrahams,F
AU  - Muzoora,C
AU  - Nakigozi,N
AU  - Nyehangane,D
AU  - Nanjebe,D
AU  - Mbega,H
AU  - Kaitano,R
AU  - Bonnet,M
AU  - Debeaudrap,P
AU  - Miró,JM
AU  - Anglaret,X
AU  - Rakotosamimanana,N
AU  - Calmy,A
AU  - Bonnet,F
AU  - Ambrosioni,J
AU  - INTENSE-TBM,Group
DO  - 10.1007/s40121-022-00667-z
EP  - 1341
PY  - 2022///
SN  - 2193-8229
SP  - 1327
TI  - Capacity building in Sub-Saharan Africa as part of the INTENSE-TBM Project during the COVID-19 pandemic
T2  - Infectious Diseases and Therapy
UR  - http://dx.doi.org/10.1007/s40121-022-00667-z
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35767219
UR  - http://hdl.handle.net/10044/1/98355
VL  - 11
ER  -
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