Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
//

Contact

 

r.j.wilkinson Website

 
 
//

Location

 

Commonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@unpublished{Davies:2022:10.1101/2022.06.28.22276983,
author = {Davies, M-A and Morden, E and Rosseau, P and Arendse, J and Bam, J-L and Boloko, L and Cloete, K and Cohen, C and Chetty, N and Dane, P and Heekes, A and Hsiao, N-Y and Hunter, M and Hussey, H and Jacobs, T and Jassat, W and Kariem, S and Kassanjee, R and Laenen, I and Le, Roux S and Lessells, R and Mahomed, H and Maughan, D and Meintjes, G and Mendelson, M and Mnguni, A and Moodley, M and Murie, K and Naude, J and Ntusi, NAB and Paleker, M and Parker, A and Pienaar, D and Preiser, W and Prozesky, H and Raubenheimer, P and Rossouw, L and Schrueder, N and Smith, B and Smith, M and Solomon, W and Symons, G and Taljaard, J and Wasserman, S and Wilkinson, RJ and Wolmarans, M and Wolter, N and Boulle, A},
doi = {10.1101/2022.06.28.22276983},
publisher = {PubMedCentral},
title = {Outcomes of laboratory-confirmed SARS-CoV-2 infection during resurgence driven by Omicron lineages BA.4 and BA.5 compared with previous waves in the Western Cape Province, South Africa.},
url = {http://dx.doi.org/10.1101/2022.06.28.22276983},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Objective: We aimed to compare clinical severity of Omicron BA.4/BA.5 infection with BA.1 and earlier variant infections among laboratory-confirmed SARS-CoV-2 cases in the Western Cape, South Africa, using timing of infection to infer the lineage/variant causing infection. Methods: We included public sector patients aged ≥20 years with laboratory-confirmed COVID-19 between 1-21 May 2022 (BA.4/BA.5 wave) and equivalent prior wave periods. We compared the risk between waves of (i) death and (ii) severe hospitalization/death (all within 21 days of diagnosis) using Cox regression adjusted for demographics, comorbidities, admission pressure, vaccination and prior infection. Results: Among 3,793 patients from the BA.4/BA.5 wave and 190,836 patients from previous waves the risk of severe hospitalization/death was similar in the BA.4/BA.5 and BA.1 waves (adjusted hazard ratio [aHR] 1.12; 95% confidence interval [CI] 0.93; 1.34). Both Omicron waves had lower risk of severe outcomes than previous waves. Prior infection (aHR 0.29, 95% CI 0.24; 0.36) and vaccination (aHR 0.17; 95% CI 0.07; 0.40 for boosted vs. no vaccine) were protective. Conclusion: Disease severity was similar amongst diagnosed COVID-19 cases in the BA.4/BA.5 and BA.1 periods in the context of growing immunity against SARS-CoV-2 due to prior infection and vaccination, both of which were strongly protective.
AU  - Davies,M-A
AU  - Morden,E
AU  - Rosseau,P
AU  - Arendse,J
AU  - Bam,J-L
AU  - Boloko,L
AU  - Cloete,K
AU  - Cohen,C
AU  - Chetty,N
AU  - Dane,P
AU  - Heekes,A
AU  - Hsiao,N-Y
AU  - Hunter,M
AU  - Hussey,H
AU  - Jacobs,T
AU  - Jassat,W
AU  - Kariem,S
AU  - Kassanjee,R
AU  - Laenen,I
AU  - Le,Roux S
AU  - Lessells,R
AU  - Mahomed,H
AU  - Maughan,D
AU  - Meintjes,G
AU  - Mendelson,M
AU  - Mnguni,A
AU  - Moodley,M
AU  - Murie,K
AU  - Naude,J
AU  - Ntusi,NAB
AU  - Paleker,M
AU  - Parker,A
AU  - Pienaar,D
AU  - Preiser,W
AU  - Prozesky,H
AU  - Raubenheimer,P
AU  - Rossouw,L
AU  - Schrueder,N
AU  - Smith,B
AU  - Smith,M
AU  - Solomon,W
AU  - Symons,G
AU  - Taljaard,J
AU  - Wasserman,S
AU  - Wilkinson,RJ
AU  - Wolmarans,M
AU  - Wolter,N
AU  - Boulle,A
DO  - 10.1101/2022.06.28.22276983
PB  - PubMedCentral
PY  - 2022///
TI  - Outcomes of laboratory-confirmed SARS-CoV-2 infection during resurgence driven by Omicron lineages BA.4 and BA.5 compared with previous waves in the Western Cape Province, South Africa.
UR  - http://dx.doi.org/10.1101/2022.06.28.22276983
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35794899
UR  - http://hdl.handle.net/10044/1/98778
ER  -
Download