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@article{Barr:2018:10.1128/JCM.01914-17,
author = {Barr, DA and Kerkhoff, AD and Schuttz, C and Ward, AM and Davies, GR and Wilkinson, RJ and Meintjes, G},
doi = {10.1128/JCM.01914-17},
journal = {Journal of Clinical Microbiology},
title = {HIV-associated M. tuberculosis blood stream infection is under-diagnosed by a single blood culture},
url = {http://dx.doi.org/10.1128/JCM.01914-17},
volume = {56},
year = {2018}
}

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TY  - JOUR
AB  - We assessed the additional diagnostic yield for Mycobacterium tuberculosis bloodstream infection (BSI) by doing more than one tuberculosis (TB) blood culture from HIV-infected inpatients. In a retrospective analysis of two cohorts based in Cape Town, South Africa, 72/99 (73%) patients with M. tuberculosis BSI were identified by the first of two blood cultures during the same admission, with 27/99 (27%; 95% confidence interval [CI], 18 to 36%) testing negative on the first culture but positive on the second. In a prospective evaluation of up to 6 blood cultures over 24 h, 9 of 14 (65%) patients with M. tuberculosis BSI had M. tuberculosis grow on their first blood culture; 3 more patients (21%) were identified by a second independent blood culture at the same time point, and the remaining 2 were diagnosed only on the 4th and 6th blood cultures. Additional blood cultures increase the yield for M. tuberculosis BSI, similar to what is reported for nonmycobacterial BSI.
AU  - Barr,DA
AU  - Kerkhoff,AD
AU  - Schuttz,C
AU  - Ward,AM
AU  - Davies,GR
AU  - Wilkinson,RJ
AU  - Meintjes,G
DO  - 10.1128/JCM.01914-17
PY  - 2018///
SN  - 0095-1137
TI  - HIV-associated M. tuberculosis blood stream infection is under-diagnosed by a single blood culture
T2  - Journal of Clinical Microbiology
UR  - http://dx.doi.org/10.1128/JCM.01914-17
UR  - http://hdl.handle.net/10044/1/56922
VL  - 56
ER  -

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