Summary
Dr Richard Kelwick is a recent Royal Society of Edinburgh Enterprise Fellow and an entrepreneurially driven researcher, at Imperial College London, with expertise in both cancer biology and synthetic biology.
Dr Kelwick has a Ph.D. in cancer biology (Prof. Dylan Edwards group, UEA), during which he researched the protective roles of metalloproteinases in cancer. His research led to mechanistic insights into the protective roles of a disintegrin-like and metalloprotease with thrombospondin type motif 15 (ADAMTS15) in breast cancer. Upon moving to Imperial in 2013, Dr Kelwick joined Prof. Paul Freemont’s group (Section of Structural and Synthetic Biology) where he developed expertise in cell-free synthetic biology. In particular, he generated several microbial and mammalian cell-free transcription-translation systems for cell-free biologics and biomaterials production. Moving forward, Dr Kelwick aims to apply his expertise in both cancer biology and synthetic biology towards the development of novel extracellular vesicle (EV) biosensors and isolation methods.
>Author of peer reviewed publications that span my research interests in synthetic biology, cancer biology and EV biology.
>Member of Imperial Postdocs and Fellows Enterprise Network (IPFEN) Committee
>Successful entries in several business competitions (including Cancer Tech Accelerator 2021, Techcelerate 2018, OneStart 2016 and Lean Launchpad 2015 with Steve Blank and Jerome Engel). Also, founding president of the UEA Enterprise and Engagement Club [2010 - 2012].
>External speaker at University of Cambridge, University of Oxford, several Kenyan research institutions, and at national and international scientific conferences (e.g. UKEV 2019, IET 2016, ECCSB 2017 [Switzerland]).
>A passion for science communication and public engagement. Interviewed on Persian TV (Manoto 1). Organised or supported events in the Science Museum, V&A museum, Tate Modern, Google London Campus, the Imperial Festival [2016; 2017] and at Harris City Academy Crystal Palace. Advisor of several iGEM teams.
Selected Publications
Journal Articles
Kelwick RJR, Webb AJ, Wang Y, et al., 2021, AL-PHA beads: bioplastic-based protease biosensors for global health applications, Materials Today, Vol:47, ISSN:1369-7021, Pages:25-37
Kelwick R, Webb A, Freemont P, 2020, Biological materials: the next frontier for cell-free synthetic biology, Frontiers in Bioengineering and Biotechnology, Vol:8, ISSN:2296-4185
Kelwick RJR, Ricci L, Chee SM, et al., 2019, Cell-free prototyping strategies for enhancing the sustainable production of polyhydroxyalkanoates bioplastics, Synthetic Biology, Vol:3, ISSN:2397-7000
Webb AJ, Kelwick R, Freemont PS, 2017, Opportunities for applying whole-cell bioreporters towards parasite detection, Microbial Biotechnology, Vol:10, ISSN:1751-7915, Pages:244-249
Webb AJ, Kelwick R, Doenhoff MJ, et al., 2016, A protease-based biosensor for the detection of schistosome cercariae, Scientific Reports, Vol:6, ISSN:2045-2322
Kelwick R, Desanlis I, Wheeler GN, et al., 2015, The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family., Genome Biology, Vol:16, ISSN:1474-760X, Pages:113-113
Conference
Webb AJ, Kelwick R, Wang Y, et al., 2019, AL-PHA beads: bioplastic-bsaed protease biosensors for global health, British Society for Parasitology Autumn Symposium, Belfast, UK
Kelwick R, Webb AJ, Wang Y, et al., 2019, ISEV2019 Abstract Book. PT09.10: Protease biomarker detection using functionalised bioplastic-based biosensors, ISEV 2019, Co-Action Publishing, ISSN:2001-3078
Webb AJ, Landeryou T, Kelwick R, et al., 2019, SPECIFIC NUCLEIC ACIDS LIGATION FOR DETECTION OF SCHISTOSOMES: SNAILS, 68th Annual Meeting of the American-Society-for-Tropical-Medicine-and-Hygiene (ASTMH), AMER SOC TROP MED & HYGIENE, Pages:182-182, ISSN:0002-9637
Webb AJ, Allan F, Kelwick R, et al., 2018, Protease-based bioreporters for the detection of schistosome cercariae, American Society of Tropical Medicine and Hygiene (ASTMH) 67th Annual Meeting, New Orleans, Louisiana, USA
Kelwick R, Webb AJ, Macdonald JT, et al., 2016, Development of a bacillus subtilis cell-free transcriptiontranslation system
Thesis Dissertations
Kelwick R, The role of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-15 (ADAMTS-15) in Breast Cancer