Publications
61 results found
Alsters SIM, Goldstone AP, Buxton JL, et al., 2015, Truncating homozygous mutation of carboxypeptidase E (CPE) in a morbidly obese female with type 2 diabetes mellitus, intellectual disability and hypogonadotrophic hypogonadism, PLOS One, Vol: 10, ISSN: 1932-6203
Carboxypeptidase E is a peptide processing enzyme, involved in cleaving numerous peptide precursors, including neuropeptides and hormones involved in appetite control and glucose metabolism. Exome sequencing of a morbidly obese female from a consanguineous family revealed homozygosity for a truncating mutation of the CPE gene (c.76_98del; p.E26RfsX68). Analysis detected no CPE expression in whole blood-derived RNA from the proband, consistent with nonsense-mediated decay. The morbid obesity, intellectual disability, abnormal glucose homeostasis and hypogonadotrophic hypogonadism seen in this individual recapitulates phenotypes in the previously described fat/fat and Cpe knockout mouse models, evidencing the importance of this peptide/hormone-processing enzyme in regulating body weight, metabolism, and brain and reproductive function in humans.
Montgomery-Taylor S, Cotton R, Manek N, et al., 2015, Using an email advice line to connect care for children., Arch Dis Child, Vol: 100, Pages: 600-601
Klaber RE, Lumsden DE, Kingdon C, 2015, Shape of Training: the right people with the right skills in the right place, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 100, Pages: 119-120, ISSN: 0003-9888
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- Citations: 8
Klaber RE, 2014, Training and learning for the future: making change happen., Postgrad Med J, Vol: 90, Pages: 183-184
Klaber RE, Roland D, 2014, Delivering quality improvement: the need to believe it is necessary, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 99, Pages: 175-179, ISSN: 0003-9888
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- Citations: 3
Hockey DJ, Fluxman J, Watson M, et al., 2014, Understanding the service use patterns of emergency department frequent attenders: could paediatric outreach be a solution?, ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, Vol: 99, ISSN: 1359-2998
Hockey DJ, Fluxman J, Watson M, et al., 2014, Understanding the service use patterns of emergency department frequent attenders: could paediatric outreach be a solution?, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 99, Pages: 90-+, ISSN: 0003-9888
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- Citations: 4
Lemer C, Cheung CRLH, Klaber RE, 2013, An introduction to quality improvement in paediatrics and child health, ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION, Vol: 98, Pages: 175-180, ISSN: 1743-0585
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- Citations: 6
Watson M, Klaber R, Haynes C, et al., 2013, Paediatric consultant GP-hotline audit, BRITISH JOURNAL OF GENERAL PRACTICE, Vol: 63, Pages: 348-348, ISSN: 0960-1643
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- Citations: 3
Hudson LD, Cumby C, Klaber RE, et al., 2013, Low levels of knowledge on the assessment of underweight in children and adolescents among middle-grade doctors in England and Wales, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 98, Pages: 309-311, ISSN: 0003-9888
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- Citations: 17
Suliman A, Klaber RE, Warren OJ, 2013, Exploiting opportunities for leadership development of surgeons within the operating theatre, INTERNATIONAL JOURNAL OF SURGERY, Vol: 11, Pages: 6-11, ISSN: 1743-9191
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- Citations: 19
Bermingham WH, Klaber RE, 2012, 'Coal miner's ankle' in a child: bilateral malleolar bursitis., Arch Dis Child, Vol: 97
Roland D, Warren O, Klaber RE, 2012, Engaging with leadership learning in the workplace (vol 380, pg 563, 2012), LANCET, Vol: 380, Pages: 1148-1148, ISSN: 0140-6736
Roland D, Warren O, Klaber RE, 2012, Engaging with leadership learning in the workplace, LANCET, Vol: 380, Pages: 563-563, ISSN: 0140-6736
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- Citations: 1
Klaber RE, Roland D, 2012, Engaging paediatricians in planning the training of our future workforce, ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION, Vol: 97, Pages: 517-U62, ISSN: 1743-0585
Fundamental reform to the way we train and develop our future workforce is planned. In order to successfully achieve change the engagement of those delivering care is necessary. In this study the authors used a novel participatory design to seek the opinions of medical students, foundation doctors, specialty trainees and consultants on some key statements regarding proposed improvements to postgraduate medical education. While there was overall agreement on many of the recommendations of the Temple report, some aspects were potentially divisive, with significant differences between the views of consultants and those more junior to them. This work emphasises the importance of engaging all members of the healthcare workforce, both present and future, in the reasons for, and outcomes of, healthcare reform.
Klaber RE, Roland D, 2012, Engaging paediatricians in planning the training of our future workforce, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 97, Pages: 517-520, ISSN: 0003-9888
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- Citations: 1
Lepee C, Klaber R, Benn J, et al., 2012, The use of a consultant-led ward round checklist to improve paediatric prescribing: An interrupted time series study, European Journal of Pediatrics
Brennan L, Watson M, Klaber R, et al., 2012, HOSPITAL EPISODE STATISTICS The importance of knowing context of hospital episode statistics when reconfiguring the NHS, BRITISH MEDICAL JOURNAL, Vol: 344, ISSN: 1756-1833
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- Citations: 18
Reece A, Klaber R, 2012, Maximising learning on ward rounds, ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION, Vol: 97, Pages: 61-67, ISSN: 1743-0585
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- Citations: 13
Roland D, Warren O, Klaber RE, 2012, Erratum: Engaging with leadership learning in the workplace (Lancet (2012) 380 (563)), The Lancet, Vol: 380, ISSN: 0140-6736
Klaber RE, Lee J, 2011, Clinical leadership and management in the NHS - Paired Learning, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 104, Pages: 436-436, ISSN: 0141-0768
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- Citations: 6
Klaber RE, Mellon AF, Melville CA, 2010, Educational supervision, ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION, Vol: 95, Pages: 124-130, ISSN: 1743-0585
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- Citations: 3
Prince NJ, Cass HD, Klaber RE, 2010, Accessing e-learning and e-resources., Med Educ, Vol: 44, Pages: 436-437
Roueché A, Hodgkinson R, Klaber R, 2010, Study leave budgets: accessing the money., Arch Dis Child Fetal Neonatal Ed, Vol: 95
Klaber RE, Roueché A, Hodgkinson R, et al., 2009, A structured approach to planning a workbased leadership development programme for doctors in training, International Journal of Clinical Leadership, Vol: 16, Pages: 121-129, ISSN: 1757-207X
Background As clinical leadership becomes an expectation in medical professionals of the future, careful consideration needs to be given to the planning, design, structure and evaluation of leadership development programmes. Aim To take a structured approach to the designing and planning of a work-based leadership development programme for paediatric doctors in training. Methods A total of 30 trainees within the London Specialty School of Paediatrics were given the opportunity to develop their leadership skills by working in small groups alongside the training programme directors in a number of areas of the work of the School. The design of the leadership programme was built around learning from three key sources, namely literature review, focus groups involving the participants, and small-groupworkshops, all ofwhich contributed to the thinking behind the ethos of the programme. Learning outcomes were derived from the Medical Leadership Competency Framework. A comprehensive evaluation of the programme, using a combination of peer assessment and self-assessment tools, was planned and piloted prior to the start of the programme. Results The literature review found very few leadership development programmes that had been fully evaluated. Where planning had been described, the benefit of aligning programmes to existing leadership curricula was highlighted. The majority of programmes took learners out of their working environment to learn. Although the focus groups provided useful information about the leadership perspectives of trainees, above all it was the process of participation that engendered confidence and a feeling of ownership in the planning and structure of the programme. This concept of trainee participation was taken further with the small-group workshops which used peer learning to produce practical ideas for the benefit of the group. Conclusions Leadership development programmes, as with all educational interventions, need to be properly planned and evalu
Klaber RE, Macdougall CF, 2009, Maximising learning opportunities in handover, ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION, Vol: 94, Pages: 118-122, ISSN: 1743-0585
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- Citations: 18
Klaber RE, Pollock I, 2009, Clinical teaching in paediatrics: understanding perceptions, motives and concerns., Arch Dis Child, Vol: 94, Pages: 371-375
BACKGROUND: Children and young people are used as cases and standardised patients in clinical exams and teaching courses. Consultation with them suggests that education and training are areas they feel they should actively participate in. AIMS: To examine the perceptions, motives and concerns of children and young people participating in exam-focused clinical teaching, and to compare these views with those of their parents, trainees and tutors. METHODS: Consultation and a pilot study were used to design an anonymised questionnaire with 5-point Likert scales and free text answers. This was sent to 112 children and young people, their parents, and tutors and trainees attending a clinical teaching course. Results were analysed using the Mann-Whitney U test. RESULTS: 71% of the questionnaires sent to children and young people and their parents were completed. For children and young people the major reasons for taking part were the enjoyment of helping people to learn (92% agreement) and wanting to "give something back" (85% agreement). Parents put significantly more emphasis on giving something back than anything else. Tutors and trainees felt the chance for children and young people to earn pocket money was their most important motivation. The major problem highlighted was that it is tiring being repeatedly examined. All children and young people and their parents said that they would participate in future clinical teaching. CONCLUSIONS: This study demonstrates that in the context of well-planned, structured clinical teaching, most children and young people are primarily motivated to participate to help educate doctors.
Selkirk L, Blumberg R, Broadhurst E, et al., 2008, A clinical guide to umbilical cord clamping, British Journal of Midwifery, Vol: 16, Pages: 714-716, ISSN: 0969-4900
Cord clamping is a routine procedure but there are potential complications that midwives should be aware of. This article provides a reminder of the physiology behind the need for cord clamping and a brief history of cord clamping methods that have been used across the world. It includes a case study to illustrate a potential consequence of inadequate clamping and offers midwives a clinical guide that considers cord assessment after clamping; what midwives should look for in caring for the cord; advice to new parents about cord care; and possible problems with the cord.
Klaber RE, Welch SB, Faust SN, 2007, Developmental assessment: practice makes perfect, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 92, Pages: 278-278, ISSN: 0003-9888
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- Citations: 1
Klaber RE, 2006, Phytophotodermatitis., Arch Dis Child, Vol: 91
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