Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Senior Lecturer in Cancer Biology



r.kypta Website




4007Institute of Reproductive and Developmental BiologyHammersmith Campus





  • BA Biochemistry, University of Oxford
  • PhD Molecular Biology, EMBL, Heidelberg
  • Postdoctoral research fellow, University of California San Francisco
  • Wellcome Trust Career Development Fellow, MRC Laboratory for Molecular Cell Biology, UCL
  • Senior Lecturer in Cancer Biology, Imperial College

Research Interests

  • Regulation of the tumour microenvironment by DKK3
  • Targeting Wnt signalling in cancer




Spethmann T, Böckelmann LC, Labitzky V, et al., 2021, Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets, Molecular Oncology, Vol:15, ISSN:1574-7891, Pages:1956-1969

Sunters A, Armstrong VJ, Zaman G, et al., 2021, Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor alpha-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of beta-Catenin Signaling, Journal of Biological Chemistry, Vol:285, ISSN:0021-9258, Pages:8743-8758

Gorroño-Etxebarria I, Aguirre U, Sanchez S, et al., 2019, Wnt-11 as a potential prognostic biomarker and therapeutic target in colorectal cancer, Cancers, Vol:11, ISSN:2072-6694

Ormaza G, Rodríguez JA, de Opakua AI, et al., 2019, The tumor suppressor ING5 is a dimeric, bivalent recognition molecule of the histone H3K4me3 mark, Journal of Molecular Biology, Vol:431, ISSN:0022-2836, Pages:2298-2319

Domenici G, Aurrekoetxea-Rodríguez I, Simões BM, et al., 2019, A Sox2–Sox9 signalling axis maintains human breast luminalprogenitor and breast cancer stem cells, Oncogene, Vol:38, ISSN:0950-9232, Pages:3151-3169

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