Publications
82 results found
Kypta RM, Waxman J, 2012, Wnt/β-catenin signalling in prostate cancer, NATURE REVIEWS UROLOGY, Vol: 9, Pages: 418-428, ISSN: 1759-4812
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- Citations: 212
Kawano Y, Romero D, Bengoa N, et al., 2012, 777 CRUCIAL ROLE OF DICKKOPF-3 IN PROSTATE MORPHOGENESIS <b> <i>IN VITRO</i> </b> AND <b> <i>IN VIVO</i> </b>, Journal of Urology, Vol: 187, ISSN: 0022-5347
Kawano Y, Romero D, Bengoa N, et al., 2012, CRUCIAL ROLE OF DICKKOPF-3 IN PROSTATE MORPHOGENESIS <i>IN VITRO</i> AND <i>IN VIVO</i>, Annual Meeting of the American-Urological-Association (AUA), Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E317-E318, ISSN: 0022-5347
Uysal-Onganer P, Kypta RM, 2012, Wnt11 in 2011-the regulation and function of a non-canonical Wnt, ACTA PHYSIOLOGICA, Vol: 204, Pages: 52-64, ISSN: 1748-1708
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- Citations: 58
Kypta R, Unda M, Carracedo A, 2012, Is the bench getting closer to the bedside in the war on cancer? A quick look at prostate cancer., Front Endocrinol (Lausanne), Vol: 3
Kawano Y, Diez S, Uysal-Onganer P, et al., 2011, SECRETED FRIZZLED RELATED PROTEIN-1 IS A NEGATIVE REGULATOR OF ANDROGEN RECEPTOR SIGNALING IN PROSTATE CANCER, Publisher: ELSEVIER SCIENCE INC, Pages: E112-E112, ISSN: 0022-5347
Campa VM, Kypta RM, 2011, Issues associated with the use of phosphospecific antibodies to localise active and inactive pools of GSK-3 in cells, BIOLOGY DIRECT, Vol: 6, ISSN: 1745-6150
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- Citations: 11
Elizalde C, Campa VM, Caro M, et al., 2011, Distinct Roles for Wnt-4 and Wnt-11 During Retinoic Acid-Induced Neuronal Differentiation, STEM CELLS, Vol: 29, Pages: 141-153, ISSN: 1066-5099
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- Citations: 42
Elizalde C, Campa VM, Caro M, et al., 2011, Distinct roles for Wnt-4 and Wnt-11 during retinoic acid-induced neuronal differentiation., Stem Cells, Vol: 29, Pages: 141-153
Retinoic acid and Wnt/β-catenin signals play important roles during neuronal differentiation but less is known about noncanonical Wnt signals in this context. We examined retinoic acid and Wnt signaling in two human embryonal carcinoma cell lines, NTERA-2 (clone D1), which undergoes neuronal differentiation in response to retinoic acid, and 2102Ep, which does not. Retinoic acid treatment inhibited β-catenin/Tcf activity in NTERA-2 cells but not in 2102Ep cells. Inhibition occurred downstream of β-catenin but did not involve competition between retinoic acid receptors and β-catenin for binding to p300 or Tcf-4. Ectopic expression of FZD1 partially restored inhibition in 2102Ep cells, suggesting the involvement of Wnt ligands. Retinoic acid treatment of NTERA-2 cells induced the expression of Wnt-4 and Wnt-11, both of which were able to inhibit β-catenin/Tcf activity. Wnt-4 and Wnt-11 were found at cell borders in islands of cells that expressed OCT4 and GFAP and were predominantly negative for Nestin, PAX6, and GATA6. Gene silencing of Wnt-4, but not Wnt-11, reduced retinoic acid downregulation of OCT4 and Nanog and upregulation of PAX6, ASCL1, HOXC5, and NEUROD1, suggesting that Wnt-4 promotes early neuronal differentiation. Gene expression analysis of NTERA-2 cells stably overexpressing Wnt-11 suggested that Wnt-11 potentiates retinoic acid induction of early neurogenesis. Consistent with this, overexpression of Wnt-11 maintained a population of proliferating progenitor cells in cultures treated with retinoic acid for several weeks. These observations highlight the distinct roles of two noncanonical Wnts during the early stages of retinoic acid-induced neuronal differentiation.
Castano Z, Gordon-Weeks PR, Kypta RM, 2010, The neuron-specific isoform of glycogen synthase kinase-3β is required for axon growth, JOURNAL OF NEUROCHEMISTRY, Vol: 113, Pages: 117-130, ISSN: 0022-3042
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- Citations: 47
Uysal-Onganer P, Kawano Y, Caro M, et al., 2010, Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells, MOLECULAR CANCER, Vol: 9
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- Citations: 118
Kawano Y, Diez S, Uysal-Onganer P, et al., 2009, Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer, BRITISH JOURNAL OF CANCER, Vol: 100, Pages: 1165-1174, ISSN: 0007-0920
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- Citations: 38
Kypta R, 2009, Wnt Signaling, Encyclopedia of cancer, Editors: Schwab, ISBN: 9783540368472
Castaño Z, Kypta RM, 2008, Housekeeping Proteins: Limitations as References During Neuronal Differentiation, The Open Neuroscience Journal, Vol: 2, Pages: 36-40, ISSN: 1874-0820
The use of “Housekeeping proteins” as loading controls in western blots requires that they do not change their level of expression. However, deviations from this rule have been observed. This study investigated the expression of the commonly used proteins HSP60, βI-tubulin, β-actin and GAPDH by western blot during retinoic acid-induced differentiation of the embryonal carcinoma NTera-2 and the neuroblastoma SH-SY5Y cell lines. β-actin was found to be a poor loading control, increasing significantly during differentiation, whereas HSP60 and GAPDH were the more evenly expressed of those analysed. Our results underline the importance of selecting accurate loading controls in this biological context.
Kawano Y, Kitaoka M, Hamada Y, et al., 2006, Regulation of prostate cell growth and morphogenesis by Dickkopf-3, ONCOGENE, Vol: 25, Pages: 6528-6537, ISSN: 0950-9232
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- Citations: 101
Kypta RM, 2005, GSK-3 inhibitors and their potential in the treatment of Alzheimer's disease, EXPERT OPINION ON THERAPEUTIC PATENTS, Vol: 15, Pages: 1315-1331, ISSN: 1354-3776
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- Citations: 25
Bergstein, 2005, Wnt genes and prostate cancer (vol 46, pg 450, 1997), CANCER RESEARCH, Vol: 65, Pages: 8057-8057, ISSN: 0008-5472
Zhu H, Mazor M, Kawano Y, et al., 2005, Erratum: Analysis of Wnt gene expression in prostate cancer: Mutual inhibition by WNT11 and the androgen receptor (Cancer Research (November 1, 2004) 64 (7918-7926)), Cancer Research, Vol: 65, ISSN: 0008-5472
Kypta RM, 2005, USE OF GSK-3 INHIBITORS FOR THE TREATMENT OF PROSTATE CANCER, WO 2006/018633 Al
Zhu HN, Mazor M, Kawano Y, et al., 2004, Analysis of Wnt gene expression in prostate cancer: Mutual enhibition by WNT11 and the androgen receptor, CANCER RESEARCH, Vol: 64, Pages: 7918-7926, ISSN: 0008-5472
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- Citations: 90
Mazor M, Kawano Y, Zhu HN, et al., 2004, Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth, ONCOGENE, Vol: 23, Pages: 7882-7892, ISSN: 0950-9232
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- Citations: 103
Giannini A, Mazor M, Orme M, et al., 2004, Nuclear export of α-catenin:: overlap between nuclear export signal sequences and the β-catenin binding site, EXPERIMENTAL CELL RESEARCH, Vol: 295, Pages: 150-160, ISSN: 0014-4827
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- Citations: 19
Orme MH, Giannini AL, Vivanco MD, et al., 2003, Glycogen synthase kinase-3 and Axin function in a β-catenin-independent pathway that regulates neurite outgrowth in neuroblastorna cells, MOLECULAR AND CELLULAR NEUROSCIENCE, Vol: 24, Pages: 673-686, ISSN: 1044-7431
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- Citations: 38
Kypta R, Zhu H, Mazor M, et al., 2003, Expression of WNT11 represess androgen receptor activity and is increased in androgen-independent prostate cancer cells, European Urology Supplements, Vol: 2, Pages: 163-163, ISSN: 1569-9056
Kawano Y, Kypta R, 2003, Secreted antagonists of the Wnt signalling pathway, JOURNAL OF CELL SCIENCE, Vol: 116, Pages: 2627-2634, ISSN: 0021-9533
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- Citations: 1304
Gascoyne DM, Kypta RM, Vivanco MDM, 2003, Glucocorticoids inhibit apoptosis during fibrosarcoma development by transcriptionally activating Bcl-x<sub>L</sub>, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 18022-18029, ISSN: 0021-9258
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- Citations: 70
Roca R, Kypta RM, Vivanco MD, 2003, Loss of P16<SUP>INK4a</SUP> results in increased glucocorticoid receptor activity during fibrosarcoma development, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 100, Pages: 3113-3118, ISSN: 0027-8424
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- Citations: 8
Kypta R, 2002, Cell Junctions, Cell Adhesion, and the Extracellular Matrix, Molecular biology of the cell, Editors: Alberts, Publisher: Garland, ISBN: 9780815332183
Giannini AL, Vivanco MDM, Kypta RM, 2000, α-Catenin inhibits <i>β</i>-catenin signaling by preventing formation of a <i>β</i>-catenin T-cell factor DNA complex, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 275, Pages: 21883-21888, ISSN: 0021-9258
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- Citations: 74
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