Imperial College London
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DrRobertKypta

Faculty of Medicine, Department of Surgery & Cancer

Senior Lecturer in Cancer Biology
 
 
 
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Contact

 

r.kypta Website

 
 
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Location

 

4007Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ramos:2019:10.3390/ijms20010119,
author = {Ramos, A and Rodríguez-Seoane, C and Rosa, I and Gorroño-Etxebarria, I and Alonso, J and Veiga, S and Korth, C and Kypta, R and García, Á and Requena, J},
doi = {10.3390/ijms20010119},
journal = {International Journal of Molecular Sciences},
title = {Proteomic studies reveal disrupted in schizophrenia 1 as a player in both neurodevelopment and synaptic function},
url = {http://dx.doi.org/10.3390/ijms20010119},
volume = {20},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A balanced chromosomal translocation disrupting DISC1 (Disrupted in Schizophrenia 1) gene has been linked to psychiatric diseases, such as major depression, bipolar disorder and schizophrenia. Since the discovery of this translocation, many studies have focused on understating the role of the truncated isoform of DISC1, hypothesizing that the gain of function of this protein could be behind the neurobiology of mental conditions, but not so many studies have focused in the mechanisms impaired due to its loss of function. For that reason, we performed an analysis on the cellular proteome of primary neurons in which DISC1 was knocked down with the goal of identifying relevant pathways directly affected by DISC1 loss of function. Using an unbiased proteomic approach, we found that the expression of 31 proteins related to neurodevelopment (e.g., CRMP-2, stathmin) and synaptic function (e.g., MUNC-18, NCS-1) is altered by DISC1 in primary mouse neurons. Hence, this study reinforces the idea that DISC1 is a unifying regulator of both neurodevelopment and synaptic function, thereby providing a link between these two key anatomical and cellular circuitries.
AU  - Ramos,A
AU  - Rodríguez-Seoane,C
AU  - Rosa,I
AU  - Gorroño-Etxebarria,I
AU  - Alonso,J
AU  - Veiga,S
AU  - Korth,C
AU  - Kypta,R
AU  - García,Á
AU  - Requena,J
DO  - 10.3390/ijms20010119
PY  - 2019///
SN  - 1422-0067
TI  - Proteomic studies reveal disrupted in schizophrenia 1 as a player in both neurodevelopment and synaptic function
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms20010119
UR  - http://hdl.handle.net/10044/1/65481
VL  - 20
ER  -
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