Imperial College London
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DrRobertKypta

Faculty of Medicine, Department of Surgery & Cancer

Senior Lecturer in Cancer Biology
 
 
 
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Contact

 

r.kypta Website

 
 
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Location

 

4007Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Al:2022:10.3390/cancers14235822,
author = {Al, Shareef Z and Ershaid, MNA and Mudhafar, R and Soliman, SSM and Kypta, RM},
doi = {10.3390/cancers14235822},
journal = {Cancers},
pages = {1--16},
title = {Dickkopf-3: an update on a potential regulator of the tumor microenvironment},
url = {http://dx.doi.org/10.3390/cancers14235822},
volume = {14},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Dickkopf-3 (Dkk-3) is a member of the Dickkopf family protein of secreted Wingless-related integration site (Wnt) antagonists that appears to modulate regulators of the host microenvironment. In contrast to the clear anti-tumorigenic effects of Dkk-3-based gene therapies, the role of endogenous Dkk-3 in cancer is context-dependent, with elevated expression associated with tumor promotion and suppression in different settings. The receptors and effectors that mediate the diverse effects of Dkk-3 have not been characterized in detail, contributing to an ongoing mystery of its mechanism of action. This review compares the various functions of Dkk-3 in the tumor microenvironment, where Dkk-3 has been found to be expressed by subpopulations of fibroblasts, endothelial, and immune cells, in addition to epithelial cells. We also discuss how the activation or inhibition of Dkk-3, depending on tumor type and context, might be used to treat different types of cancers.
AU  - Al,Shareef Z
AU  - Ershaid,MNA
AU  - Mudhafar,R
AU  - Soliman,SSM
AU  - Kypta,RM
DO  - 10.3390/cancers14235822
EP  - 16
PY  - 2022///
SN  - 2072-6694
SP  - 1
TI  - Dickkopf-3: an update on a potential regulator of the tumor microenvironment
T2  - Cancers
UR  - http://dx.doi.org/10.3390/cancers14235822
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000896215800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.mdpi.com/2072-6694/14/23/5822
UR  - http://hdl.handle.net/10044/1/101568
VL  - 14
ER  -
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