Imperial College London
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Prof Rob Law

Faculty of Natural Sciences, Department of Chemistry

Professor of Biological Materials
 
 
 
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Contact

 

+44 (0)20 7594 5860r.law Website

 
 
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Location

 

207GMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Molisso:2021:10.1098/rsif.2021.0698,
author = {Molisso, S and Williams, DR and Ces, O and Rowlands, LJ and Marsh, JM and Law, RV},
doi = {10.1098/rsif.2021.0698},
journal = {Journal of the Royal Society Interface},
pages = {1--8},
title = {Molecular interaction and partitioning in α-Keratin using 1H NMR Spin-Lattice (T1) relaxation times},
url = {http://dx.doi.org/10.1098/rsif.2021.0698},
volume = {18},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The interactions between small molecules and keratins are poorly understood. In this paper an NMR method is presented to measure changes in the 1H T1 relaxation times of small molecules in human hair keratin to quantify their interaction with the fiber. Two populations of small molecule compounds were identified with distinct relaxation times, demonstrating the partitioning of the compounds into different keratin environments. The changes in relaxation time for solvent in hair compared to bulk solvent were shown to be related to the molecular weight, MW, and the partition coefficient, LogP, of the solvent investigated. Compounds with low molecular weights and high hydrophilicities had greater reductions in their T1 relaxation times and therefore experienced increased interactions with the hair fiber.  The relative population sizes were also calculated. This is a significant step toward modelling the behavior of small molecules in keratinous materials and other large insoluble fibrous proteins.
AU  - Molisso,S
AU  - Williams,DR
AU  - Ces,O
AU  - Rowlands,LJ
AU  - Marsh,JM
AU  - Law,RV
DO  - 10.1098/rsif.2021.0698
EP  - 8
PY  - 2021///
SN  - 1742-5662
SP  - 1
TI  - Molecular interaction and partitioning in α-Keratin using 1H NMR Spin-Lattice (T1) relaxation times
T2  - Journal of the Royal Society Interface
UR  - http://dx.doi.org/10.1098/rsif.2021.0698
UR  - https://royalsocietypublishing.org/doi/10.1098/rsif.2021.0698
UR  - http://hdl.handle.net/10044/1/92487
VL  - 18
ER  -
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