Publications
168 results found
DOMINGO GJ, LEATHERBARROW RJ, 1994, USE OF SYNTHETIC PEPTIDE LIBRARIES TO SCREEN FOR PROTEINASE-INHIBITORS, JOURNAL OF CELLULAR BIOCHEMISTRY, Pages: 154-154, ISSN: 0730-2312
MATTHEWS SJ, LEATHERBARROW RJ, 1993, THE USE OF OSMOLYTES TO FACILITATE PROTEIN NMR-SPECTROSCOPY, JOURNAL OF BIOMOLECULAR NMR, Vol: 3, Pages: 597-600, ISSN: 0925-2738
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- Citations: 19
MATTHEWS SJ, JANDU SK, LEATHERBARROW RJ, 1993, C-13 NMR-STUDY OF THE EFFECTS OF MUTATION ON THE TRYPTOPHAN DYNAMICS IN CHYMOTRYPSIN INHIBITOR .2. CORRELATIONS WITH STRUCTURE AND STABILITY (VOL 32, PG 657, 1993), BIOCHEMISTRY, Vol: 32, Pages: 4474-4474, ISSN: 0006-2960
MATTHEWS SJ, JANDU SK, LEATHERBARROW RJ, 1993, C-13 NMR-STUDY OF THE EFFECTS OF MUTATION ON THE TRYPTOPHAN DYNAMICS IN CHYMOTRYPSIN INHIBITOR-2 - CORRELATIONS WITH STRUCTURE AND STABILITY, BIOCHEMISTRY, Vol: 32, Pages: 657-662, ISSN: 0006-2960
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- Citations: 21
LEATHERBARROW RJ, MATTHEWS SJ, 1992, C-13 NUCLEAR-MAGNETIC-RESONANCE RELAXATION STUDY OF CHYMOTRYPSIN INHIBITOR-2 (CI-2), MAGNETIC RESONANCE IN CHEMISTRY, Vol: 30, Pages: 1255-1260, ISSN: 0749-1581
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- Citations: 3
Wells TN, Stedman M, Leatherbarrow RJ, 1992, Imaging of proteins by scanning tunnelling microscopy., Ultramicroscopy, Vol: 42-44 ( Pt B), Pages: 1200-1203, ISSN: 0304-3991
Scanning tunnelling microscopy has been used to examine the structure of proteins deposited on a graphite surface. Three molecules have been studied; immunoglobulin G (IgG), Complement component 1q (C1q) and ATP-citrate lyase (ACL). The images show IgG as a tri-lobed molecule, consistent with the known 3D structure as determined by X-ray crystallography. The C1q images differ from the well known "tulip bunch" model derived by electron microscopy, but are consistent with the model if it is assumed that the six globular heads have aggregated. Molecules of ACL are visible as discrete units, with some hints of substructure. These results highlight the potential of STM in studying protein structures, but also illustrate the difficulties of interpreting micrographs of proteins whose structure is currently unknown.
WELLS TNC, STEDMAN M, LEATHERBARROW RJ, 1992, IMAGING OF PROTEINS BY SCANNING TUNNELING MICROSCOPY, ULTRAMICROSCOPY, Vol: 42, Pages: 1200-1203, ISSN: 0304-3991
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- Citations: 9
Leatherbarrow RJ, 1992, GraFit version 3.0. Data Analysis and Graphics program for the IBM PC., Staines, UK, Publisher: Erithacus Software
RUDD PM, LEATHERBARROW RJ, RADEMACHER TW, et al., 1991, DIVERSIFICATION OF THE IGG MOLECULE BY OLIGOSACCHARIDES, MOLECULAR IMMUNOLOGY, Vol: 28, Pages: 1369-1378, ISSN: 0161-5890
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- Citations: 62
LEATHERBARROW RJ, SALACINSKI HJ, 1991, DESIGN OF A SMALL PEPTIDE-BASED PROTEINASE-INHIBITOR BY MODELING THE ACTIVE-SITE REGION OF BARLEY CHYMOTRYPSIN INHIBITOR-2, BIOCHEMISTRY, Vol: 30, Pages: 10717-10721, ISSN: 0006-2960
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- Citations: 21
LEATHERBARROW RJ, STEDMAN M, WELLS TNC, 1991, STRUCTURE OF IMMUNOGLOBULIN-G BY SCANNING TUNNELING MICROSCOPY, JOURNAL OF MOLECULAR BIOLOGY, Vol: 221, Pages: 361-365, ISSN: 0022-2836
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- Citations: 43
LEATHERBARROW RJ, 1990, CATALYTIC ANTIBODIES - ON TO THE 2ND GENERATION, NATURE, Vol: 348, Pages: 482-482, ISSN: 0028-0836
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- Citations: 2
Leatherbarrow RJ, 1990, Catalytic antibodies. On to the second generation., Nature, Vol: 348, ISSN: 0028-0836
LEATHERBARROW RJ, 1990, USING LINEAR AND NONLINEAR-REGRESSION TO FIT BIOCHEMICAL DATA, TRENDS IN BIOCHEMICAL SCIENCES, Vol: 15, Pages: 455-458, ISSN: 0968-0004
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- Citations: 174
LEATHERBARROW RJ, 1990, EXAMINATION OF THE STRUCTURE AND STABILITY OF ENGINEERED PROTEINS BY NMR, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol: 200, Pages: 53-BIOT, ISSN: 0065-7727
WANG NY, SOUTHAN C, DEWOLF WE, et al., 1990, BOVINE DOPAMINE BETA-HYDROXYLASE, PRIMARY STRUCTURE DETERMINED BY CDNA CLONING AND AMINO-ACID SEQUENCING, BIOCHEMISTRY, Vol: 29, Pages: 6466-6474, ISSN: 0006-2960
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- Citations: 23
JANDU SK, RAY S, BROOKS L, et al., 1990, ROLE OF ARGININE-67 IN THE STABILIZATION OF CHYMOTRYPSIN INHIBITOR-2 - EXAMINATION OF AMIDE PROTON-EXCHANGE RATES AND DENATURATION THERMODYNAMICS OF AN ENGINEERED PROTEIN, BIOCHEMISTRY, Vol: 29, Pages: 6264-6269, ISSN: 0006-2960
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- Citations: 46
GARCIA GA, LEATHERBARROW RJ, ECKSTEIN F, et al., 1990, METAL-ION DEPENDENCE OF PHOSPHOROTHIOATE ATP ANALOGS IN THE BACILLUS-STEAROTHERMOPHILUS TYROSYL-TRANSFER RNA-SYNTHETASE REACTION, BIOCHEMISTRY, Vol: 29, Pages: 1643-1648, ISSN: 0006-2960
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- Citations: 10
LEATHERBARROW RJ, 1990, USE OF NONLINEAR-REGRESSION TO ANALYZE ENZYME KINETIC DATA - APPLICATION TO SITUATIONS OF SUBSTRATE CONTAMINATION AND BACKGROUND SUBTRACTION, ANALYTICAL BIOCHEMISTRY, Vol: 184, Pages: 274-278, ISSN: 0003-2697
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- Citations: 32
SELF SJ, HUNTER CN, LEATHERBARROW RJ, 1990, MOLECULAR-CLONING, SEQUENCING AND EXPRESSION OF CYTOCHROME-C2 FROM RHODOSPIRILLUM-RUBRUM, BIOCHEMICAL JOURNAL, Vol: 265, Pages: 599-604, ISSN: 0264-6021
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- Citations: 17
Leatherbarrow RJ, 1990, GraFit version 2.0. Data Analysis and Graphics program for the IBM PC., Staines, UK, Publisher: Erithacus Software
Leatherbarrow RJ, 1989, Designer catalytic antibodies., Nature, Vol: 338, Pages: 206-207, ISSN: 0028-0836
LEATHERBARROW RJ, 1989, ENZYME CHEMISTRY - DESIGNER CATALYTIC ANTIBODIES, NATURE, Vol: 338, Pages: 206-207, ISSN: 0028-0836
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- Citations: 3
Self SJ, Hunter CN, Leatherbarrow RJ, 1989, Cloning the Gene for Cytochrome c2 from Rhodospirillum rubrum, Techniques and New Developments in Photosynthesis Research, Editors: Barber, Malkin, Pages: 477-448
Leatherbarrow RJ, 1988, Mouse + micro = molecular model. Alchemy<sup>™</sup> Molecular modelling software for..., Trends in Biochemical Sciences, Vol: 13, Pages: 188-189, ISSN: 0968-0004
Title full: Mouse + micro = molecular model. Alchemy™ Molecular modelling software for the IBM (PC, AT, XT or compatible) Tripos Associates Inc.* * Tripos Associates, Inc., 6548 Clayton Road, St Louis, MO 63117, USA. Distributed by Evans & Sutherland through their offices in: Munich, FRG; Cambridge, UK; Palaiseau, France., 1986. US$750 commercial/$450 educational users. Alchemy is a difficult product to. © 1988.
LEATHERBARROW RJ, FERSHT AR, 1987, INVESTIGATION OF TRANSITION-STATE STABILIZATION BY RESIDUES HISTIDINE-45 AND THREONINE-40 IN THE TYROSYL-TRANSFER RNA-SYNTHETASE, BIOCHEMISTRY, Vol: 26, Pages: 8524-8528, ISSN: 0006-2960
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- Citations: 41
Leatherbarrow RJ, 1987, Enzfitter. A non-linear regression data analysis program for the IBM PC, Amsterdam, Publisher: Elsevier Science Publishers BV
FERSHT AR, LEATHERBARROW RJ, WELLS TNC, 1987, STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS - ANALYSIS OF USE OF BINDING-ENERGY BY LINEAR FREE-ENERGY RELATIONSHIPS, BIOCHEMISTRY, Vol: 26, Pages: 6030-6038, ISSN: 0006-2960
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- Citations: 149
FERSHT AR, LEATHERBARROW RJ, WELLS TNC, 1986, BINDING-ENERGY AND CATALYSIS - A LESSON FROM PROTEIN ENGINEERING OF THE TYROSYL-TRANSFER RNA-SYNTHETASE, TRENDS IN BIOCHEMICAL SCIENCES, Vol: 11, Pages: 321-325, ISSN: 0968-0004
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- Citations: 76
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