Publications
411 results found
Giannakidis A, Nyktari E, Keegan J, et al., 2015, Rapid automatic segmentation of abnormal tissue in late gadolinium enhancement cardiovascular magnetic resonance images for improved management of long‑standing persistent atrial fibrillation, Biomedical Engineering Online, Vol: 14, ISSN: 1475-925X
Giannakidis A, Nyktari E, Keegan J, et al., 2015, Rapid automatic segmentation of abnormal tissue in late gadolinium enhancement cardiovascular magnetic resonance images for improved management of long-standing persistent atrial fibrillation., Biomedical Engineering Online, Vol: 14, ISSN: 1475-925X
BACKGROUND: Atrial fibrillation (AF) is the most common heart rhythm disorder. In order for late Gd enhancement cardiovascular magnetic resonance (LGE CMR) to ameliorate the AF management, the ready availability of the accurate enhancement segmentation is required. However, the computer-aided segmentation of enhancement in LGE CMR of AF is still an open question. Additionally, the number of centres that have reported successful application of LGE CMR to guide clinical AF strategies remains low, while the debate on LGE CMR's diagnostic ability for AF still holds. The aim of this study is to propose a method that reliably distinguishes enhanced (abnormal) from non-enhanced (healthy) tissue within the left atrial wall of (pre-ablation and 3 months post-ablation) LGE CMR data-sets from long-standing persistent AF patients studied at our centre. METHODS: Enhancement segmentation was achieved by employing thresholds benchmarked against the statistics of the whole left atrial blood-pool (LABP). The test-set cross-validation mechanism was applied to determine the input feature representation and algorithm that best predict enhancement threshold levels. RESULTS: Global normalized intensity threshold levels T PRE = 1 1/4 and T POST = 1 5/8 were found to segment enhancement in data-sets acquired pre-ablation and at 3 months post-ablation, respectively. The segmentation results were corroborated by using visual inspection of LGE CMR brightness levels and one endocardial bipolar voltage map. The measured extent of pre-ablation fibrosis fell within the normal range for the specific arrhythmia phenotype. 3D volume renderings of segmented post-ablation enhancement emulated the expected ablation lesion patterns. By comparing our technique with other related approaches that proposed different threshold levels (although they also relied on reference regions from within the LABP) for segmenting enhancement in LGE CMR data-sets of AF patients, we illustra
Austin C, Golesworthy T, Izgi C, et al., 2015, Personalized Aortic Root Support With Mesh Provides Optimal Valve Conservation, ANNALS OF THORACIC SURGERY, Vol: 100, Pages: 1509-1510, ISSN: 0003-4975
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- Citations: 1
Page M, Grasso AE, Carpenter J-P, et al., 2015, Primary Cardiac Lymphoma: Diagnosis and the Impact of Chemotherapy on Cardiac Structure and Function, Canadian Journal of Cardiology, Vol: 32, Pages: 931.e1-931.e3, ISSN: 1916-7075
We report a case of primary cardiac lymphoma presenting as myopericarditis and rapidly deteriorating into biventricular heart failure and ventricular arrhythmias. Computed tomography and cardiac magnetic resonance (CMR) imaging showed extensive myocardial infiltration with typical patterns on tissue characterization CMR images, raising clinical suspicion. Diagnosis was confirmed by myocardial histologic examination. Marked regression of tumor burden was apparent after 6 cycles of anthracycline-based chemotherapy. This case illustrates that a high degree of suspicion for this rare entity is mandated to institute timely treatment. Rapid tumor lysis may induce life-threatening acute cardiac decompensation that requires intensive monitoring and support therapy.
Pepper J, Goddard M, Mohiaddin R, et al., 2015, Histology of a Marfan aorta 4.5 years after personalized external aortic root support, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 48, Pages: 502-505, ISSN: 1010-7940
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- Citations: 26
Patel HC, Moser JB, Otero S, et al., 2015, The proximity of abdominal structures to the renal artery: a study to assess the potential risks of renal denervation, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 657-658, ISSN: 0195-668X
Patel HC, Otero S, Moser JB, et al., 2015, A cross-sectional imaging study to identify organs at risk of thermal injury during renal artery sympathetic denervation, International Journal of Cardiology, Vol: 197, Pages: 235-240, ISSN: 1874-1754
BackgroundThe technology used to perform catheter-based renal artery sympathetic denervation has evolved: catheters can now access arteries as small as 3 mm in diameter and create ablation zones of up to 10 mm in depth. Recent evidence suggests that the procedure may be more effective if a more thorough ablation strategy is employed. Limited data are available regarding inadvertent soft tissue thermal injury during such procedures. We used computed tomography (CT) to identify structures lying within the expected thermal ablation field or the ‘at risk zone’ (ARZ).Methods63 consecutive CT aortograms were reviewed, yielding 100 renal arteries anatomically eligible for treatment. Structures lying within a predefined ARZ (within 10 mm of the renal artery wall) were recorded.ResultsThe 63 subjects had a mean age of 74.6 years, 48% were males and 88% had hypertension. The inferior vena cava and renal veins were in the ARZ in all cases. Psoas muscles and small bowel were within the ARZ in at least a fifth of the kidneys. Other structures found in the ARZ included the liver, pancreas, adrenal glands and diaphragm.ConclusionsThis study describes the variable anatomical relationship between renal arteries and important abdominal structures that may be exposed to thermal energy during modern denervation procedures. The consequence of delivering such thermal energy to these structures is unknown but clinicians should be alert to the presenting symptoms if these structures are damaged. CT may have a pre-procedure role in assessing this risk.Keywords Renal denervation; Safety; Anatomy; Ablation; Cross-sectional imaging
Singh SD, Xu XY, Pepper JR, et al., 2015, Biomechanical properties of the Marfan's aortic root and ascending aorta before and after personalised external aortic root support surgery., Medical Engineering & Physics, Vol: 37, Pages: 759-766, ISSN: 1873-4030
Marfan syndrome is an inherited systemic connective tissue disease which may lead to aortic root disease causing dilatation, dissection and rupture of the aorta. The standard treatment is a major operation involving either an artificial valve and aorta or a complex valve repair. More recently, a personalised external aortic root support (PEARS) has been used to strengthen the aorta at an earlier stage of the disease avoiding risk of both rupture and major surgery. The aim of this study was to compare the stress and strain fields of the Marfan aortic root and ascending aorta before and after insertion of PEARS in order to understand its biomechanical implications. Finite element (FE) models were developed using patient-specific aortic geometries reconstructed from pre and post-PEARS magnetic resonance images in three Marfan patients. For the post-PEARS model, two scenarios were investigated-a bilayer model where PEARS and the aortic wall were treated as separate layers, and a single-layer model where PEARS was incorporated into the aortic wall. The wall and PEARS materials were assumed to be isotropic, incompressible and linearly elastic. A static load on the inner wall corresponding to the patients' pulse pressure was applied. Results from our FE models with patient-specific geometries show that peak aortic stresses and displacements before PEARS were located at the sinuses of Valsalva but following PEARS surgery, these peak values were shifted to the aortic arch, particularly at the interface between the supported and unsupported aorta. Further studies are required to assess the statistical significance of these findings and how PEARS compares with the standard treatment.
Lindsay AC, Mohiaddin RH, 2015, The emerging roles of cardiovascular magnetic resonance imaging in transcatheter aortic valve implantation (TAVI), EUROINTERVENTION, Vol: 11, Pages: 137-139, ISSN: 1774-024X
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- Citations: 1
Treasure T, Pepper J, Mohiaddin R, 2015, Atenolol versus Losartan in Marfan's Syndrome, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 372, Pages: 979-980, ISSN: 0028-4793
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- Citations: 3
Treasure T, Pepper J, Mohiaddin R, 2015, Atenolol versus Losartan in Marfan's Syndrome., N Engl J Med, Vol: 372, Pages: 978-979
Keegan J, Patel HC, Simpson RM, et al., 2015, Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics, Journal of Cardiovascular Magnetic Resonance, Vol: 17, ISSN: 1532-429X
Wage R, Patel H, Smith GC, et al., 2015, The utility of magnetic resonance imaging in a trial to assess the effect of renal denervation in heart failure with preserved ejection fraction, Journal of Cardiovascular Magnetic Resonance, Pages: 1-2, ISSN: 1097-6647
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- Citations: 1
Keegan J, Patel H, Simpson R, et al., 2015, Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647
Heng EL, Kellman P, Mohiaddin R, et al., 2015, The utility of free-breathing, motion-corrected late gadolinium enhancement for right ventricular fibrosis imaging in congenital heart disease, Journal of Cardiovascular Magnetic Resonance, Pages: 1-2, ISSN: 1097-6647
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- Citations: 1
Raphael CE, Alpendurada F, Prasad SK, et al., 2015, The clinical value of Cardiovascular Magnetic Resonance in patients with MR-conditional pacemakers, Journal of Cardiovascular Magnetic Resonance, Pages: 1-1, ISSN: 1097-6647
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- Citations: 1
Ali OF, Schultz C, Jabbour A, et al., 2015, Predictors of paravalvular aortic regurgitation following self-expanding Medtronic CoreValve implantation: The role of annulus size, degree of calcification, and balloon size during pre-implantation valvuloplasty and implant depth, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 179, Pages: 539-545, ISSN: 0167-5273
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- Citations: 23
Pennell DJ, Baksi AJ, Kilner PJ, et al., 2014, Review of Journal of Cardiovascular Magnetic Resonance 2013, Journal of Cardiovascular Magnetic Resonance, Vol: 16, ISSN: 1532-429X
There were 109 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2013, which is a21% increase on the 90 articles published in 2012. The quality of the submissions continues to increase. The editorsare delighted to report that the 2012 JCMR Impact Factor (which is published in June 2013) has risen to 5.11, upfrom 4.44 for 2011 (as published in June 2012), a 15% increase and taking us through the 5 threshold for the firsttime. The 2012 impact factor means that the JCMR papers that were published in 2010 and 2011 were cited onaverage 5.11 times in 2012. The impact factor undergoes natural variation according to citation rates of papers inthe 2 years following publication, and is significantly influenced by highly cited papers such as official reports.However, the progress of the journal's impact over the last 5 years has been impressive. Our acceptance rate is<25% and has been falling because the number of articles being submitted has been increasing. In accordancewith Open-Access publishing, the JCMR articles go on-line as they are accepted with no collating of the articlesinto sections or special thematic issues. For this reason, the Editors have felt that it is useful once per calendaryear to summarize the papers for the readership into broad areas of interest or theme, so that areas of interestcan be reviewed in a single article in relation to each other and other recent JCMR articles. The papers arepresented in broad themes and set in context with related literature and previously published JCMR papers toguide continuity of thought in the journal. We hope that you find the open-access system increases widerreading and citation of your papers, and that you will continue to send your quality manuscripts to JCMR forpublication.
Lindsay AC, Snow T, Jabbour RJ, et al., 2014, Right Ventricular Ejection Fraction Measured by Cardiovascular Magnetic Resonance Independently Predicts Mortality Following Transcatheter Aortic Valve Implantation, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
Raphael CE, Baksi AJ, Alpendurada F, et al., 2014, Cardiovascular magnetic resonance in patients with MRI-conditional pacemakers: a single centre experience, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 798-799, ISSN: 0195-668X
Izgi C, Nyktari E, Alpendurada F, et al., 2014, Changes in aortic root motion and distension after personalized external aortic root support surgery in Marfan syndrome, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 37-37, ISSN: 0195-668X
Patel HC, Keegan J, Simpson R, et al., 2014, A novel MRI technique to examine renal blood flow: could it be used to evaluate the effects of renal artery interventions?, Annual Meeting of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 641-641, ISSN: 0195-668X
Treasure T, Takkenberg JJM, Golesworthy T, et al., 2014, Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1-9 year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the published results of aortic root replacement, HEART, Vol: 100, Pages: 969-975, ISSN: 1355-6037
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- Citations: 62
Chen SSM, Dimopoulos K, Alonso-Gonzalez R, et al., 2014, Prevalence and prognostic implication of restenosis or dilatation at the aortic coarctation repair site assessed by cardiovascular MRI in adult patients late after coarctation repair, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 173, Pages: 209-215, ISSN: 0167-5273
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- Citations: 21
Secchi F, Cannao P, Pluchinotta F, et al., 2014, These abstracts have been selected for VIEWING only as ePosters and in print. ePosters will be available on Screen A & B throughout the meeting, Print Posters at the times indicated below. Please refer to the PROGRAM for more details., Eur Heart J Cardiovasc Imaging, Vol: 15 Suppl 1, Pages: i12-i33
Vassiliou V, Raphael C, Ali A, et al., 2014, MIDWALL FIBROSIS AND LONG-TERM OUTCOME IN PATIENTS WITH AORTIC STENOSIS, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 63, Pages: A1199-A1199, ISSN: 0735-1097
Lindsay AC, Snow T, Jabbour RI, et al., 2013, Indexed Left Ventricular Mass Measured by Cardiovascular Magnetic Resonance Independently Predicts Mortality Following Transcatheter Aortic Valve Implantation, Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
Bradlow WM, Babu-Narayan SV, Mohiaddin RH, 2013, Pulmonary hypertension in congenital heart disease, Cardiac CT and MR for Adult Congenital Heart Disease, Pages: 553-572, ISBN: 9781461488743
The occurrence of pulmonary hypertension (PH) in patients with congenital heart disease (CHD) is not uncommon and represents an important complication. This chapter sets out the scale of the problem before describing where cross-sectional imaging is used in diagnosis. Prognostication and assessment of therapeutic effect using these techniques is then explored before examining Eisenmenger's syndrome in detail. A discussion on related abnormalities of the pulmonary arteries is included.
Deac M, Alpendurada F, Fanaie F, et al., 2013, Prognostic value of cardiovascular magnetic resonance in patients with suspected arrhythmogenic right ventricular cardiomyopathy, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 3514-3521, ISSN: 0167-5273
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- Citations: 40
Pennell DJ, Baksi AJ, Carpenter JP, et al., 2013, Review of Journal of Cardiovascular Magnetic Resonance 2012, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 15, ISSN: 1097-6647
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- Citations: 5
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