Imperial College London
Alternate

ProfessorRaadMohiaddin

Faculty of Medicine, National Heart & Lung Institute

Professor Cardiovascular Imaging
 
 
 
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Contact

 

r.mohiaddin

 
 
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Location

 

3012Cardiovascular MR UnitRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Azzu:2021:10.4250/jcvi.2020.0223,
author = {Azzu, A and Morosin, M and Antonopoulos, AS and Capoccia, M and Rosendahl, U and Mohiaddin, R},
doi = {10.4250/jcvi.2020.0223},
journal = {J Cardiovasc Imaging},
pages = {361--372},
title = {Cardiac Decompression by Pericardiectomy for Constrictive Pericarditis: Multimodality Imaging to Identify Patients at Risk for Prolonged Inotropic Support.},
url = {http://dx.doi.org/10.4250/jcvi.2020.0223},
volume = {29},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Post-pericardiectomy right ventricular (RV) failure has been reported but it remains not well-studied. To investigate imaging parameters that could predict RV function and the outcome of patients post-pericardiectomy. METHODS: We analysed data from a total of 53 CP patients undergoing pericardiectomy. Preoperative, early and at 6 months postoperative echocardiographic (echo) imaging datasets were analysed and correlated with preoperative cardiac magnetic resonance (CMR), cardiac computed tomography scans and histology. The primary endpoint of the study was RV functional status early postoperatively and at 6 months. Secondary endpoint was the need for prolonged inotropic support. RESULTS: A cause of CP was identified in 26 patients (49%). Inotropic support ≥ 48 hours was required in n = 28 (53%) of patients and was correlated with lower preoperative RV areas by echo or RV volumes by CMR (p < 0.05 for all). A pericardial score based on pericardial thickness/calcification and epicardial fat thickness had good diagnostic accuracy to identify patients requiring prolonged use of inotropes (area under the curve, 0.825; 95% confidence interval, 0.674-0.976). Pericardiectomy resulted in RV decompression and impaired RV function early postoperatively (fractional area change: 40.5% ± 8.8% preoperatively vs. 31.4% ± 10.4% early postoperatively vs. 42.5% ± 10.2% at 6 months, p < 0.001). CONCLUSIONS: We show that a smaller RV cavity size and a pericardial scoring system are associated with prolonged inotropic support in CP patients undergoing pericardiectomy. RV systolic impairment post decompression is present in most patients, but it is only transient.
AU  - Azzu,A
AU  - Morosin,M
AU  - Antonopoulos,AS
AU  - Capoccia,M
AU  - Rosendahl,U
AU  - Mohiaddin,R
DO  - 10.4250/jcvi.2020.0223
EP  - 372
PY  - 2021///
SP  - 361
TI  - Cardiac Decompression by Pericardiectomy for Constrictive Pericarditis: Multimodality Imaging to Identify Patients at Risk for Prolonged Inotropic Support.
T2  - J Cardiovasc Imaging
UR  - http://dx.doi.org/10.4250/jcvi.2020.0223
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34080350
VL  - 29
ER  -
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