Imperial College London
Alternate

Dr. Rebekah E. T. Moore

Faculty of Engineering, Department of Earth Science & Engineering

Research Fellow
 
 
 
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Contact

 

r.moore13 Website

 
 
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Location

 

4.40/20Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sullivan:2020:10.1039/d0mt00122h,
author = {Sullivan, K and Moore, RET and Rehkämper, M and Leybourne, MI and Layton-Matthews, D and Puxty, J and Kyser, K},
doi = {10.1039/d0mt00122h},
journal = {Metallomics},
title = {Postprandial zinc stable isotope response in human blood serum},
url = {http://dx.doi.org/10.1039/d0mt00122h},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In recent years, considerable advances have been made in the field of medical isotope metallomics, but numerous fundamental physiological processes remain to be investigated. Past studies report that blood serum Zn concentration decrease by about 20%, depending on the size of meal, approximately 3 hours postprandially (i.e. after eating), before returning to baseline values if no meals are consumed over the following 4 to 5 hours. Nine participants were recruited for this study to investigate whether this postprandial Zn concentration decrease is accompanied by a stable isotope response. A baseline serum sample was collected from participants in the morning after overnight fasting. A 576 kcal meal was then provided and additional serum samples were taken 90 and 180 minutes post-meal to coincide with the peak postprandial response. Serum Zn concentrations decreased postprandially by an average of 21 ± 9% (1SD), but this was not accompanied by a change in stable Zn isotope composition (mean Δ66Zn180-minute – Baseline = 0.01 ± 0.09‰, 2SD). We propose that hemodilution and the rapid, efficient postprandial transfer of albumin-bound Zn from serum to the liver and pancreas is responsible for the lack of postprandial serum Zn isotopic response. These results indicate that studies examining solely the distribution of Zn isotopes in serum may obtain samples without considering timing of the most recent meal. However, future studies seeking to compare serum Zn concentrations with δ66Zn values should draw blood samples in the morning after overnight fasting.
AU  - Sullivan,K
AU  - Moore,RET
AU  - Rehkämper,M
AU  - Leybourne,MI
AU  - Layton-Matthews,D
AU  - Puxty,J
AU  - Kyser,K
DO  - 10.1039/d0mt00122h
PY  - 2020///
SN  - 1756-5901
TI  - Postprandial zinc stable isotope response in human blood serum
T2  - Metallomics
UR  - http://dx.doi.org/10.1039/d0mt00122h
UR  - https://pubs.rsc.org/en/Content/ArticleLanding/2020/MT/D0MT00122H#!divAbstract
UR  - http://hdl.handle.net/10044/1/80310
ER  -
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