Publications
141 results found
Newson RB, 2012, Sensible parameters for univariate and multivariate splines, STATA JOURNAL, Vol: 12, Pages: 479-504, ISSN: 1536-867X
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- Citations: 19
Newson RB, 2012, From resultssets to resultstables in Stata, STATA JOURNAL, Vol: 12, Pages: 191-213, ISSN: 1536-867X
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- Citations: 3
Figgitt M, Newson R, Leslie I, et al., 2011, Genomic instability induced by orthopaedic wear debris in cultured human fibroblasts, TOXICOLOGY, Vol: 290, Pages: 115-116, ISSN: 0300-483X
Sood A, Salih S, Roh D, et al., 2011, Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness, NATURE NANOTECHNOLOGY, Vol: 6, Pages: 824-833, ISSN: 1748-3387
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- Citations: 98
Hastan D, Fokkens WJ, Bachert C, et al., 2011, Chronic rhinosinusitis in Europe - an underestimated disease. A GA<SUP>2</SUP>LEN study, ALLERGY, Vol: 66, Pages: 1216-1223, ISSN: 0105-4538
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- Citations: 717
Hastan D, Fokkens W, Bachert C, et al., 2011, Chronic rhinosinusitis in Europe - an underestimated disease. A GA<SUP>2</SUP>LEN study, 30th Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY-BLACKWELL, Pages: 128-128, ISSN: 0105-4538
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- Citations: 2
Tomassen P, Newson RB, Hoffmans R, et al., 2011, Reliability of EP3OS symptom criteria and nasal endoscopy in the assessment of chronic rhinosinusitis - a GA2LEN study, ALLERGY, Vol: 66, Pages: 556-561, ISSN: 0105-4538
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- Citations: 99
Jarvis DL, Natiuc L, Newson PB, 2010, ASTHMA, PUBERTY AND BMI IN THE 1958 BRITISH BIRTH COHORT, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A51-A51, ISSN: 0040-6376
Shaheen SO, Newson RB, Ring SM, et al., 2010, Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 126, Pages: 1141-U124, ISSN: 0091-6749
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- Citations: 83
Henderson AJ, Newson RB, Rose-Zerilli M, et al., 2010, Maternal Nrf2 and gluthathione-S-transferase polymorphisms do not modify associations of prenatal tobacco smoke exposure with asthma and lung function in school-aged children, THORAX, Vol: 65, Pages: 897-902, ISSN: 0040-6376
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- Citations: 32
Figgitt M, Newson R, Leslie IJ, et al., 2010, The genotoxicity of physiological concentrations of chromium (Cr(III) and Cr(VI)) and cobalt (Co(II)): An <i>in vitro</i> study, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol: 688, Pages: 53-61, ISSN: 0027-5107
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- Citations: 58
Shaheen SO, Newson RB, Smith GD, et al., 2010, Prenatal paracetamol exposure and asthma: further evidence against confounding, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 39, Pages: 790-794, ISSN: 0300-5771
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- Citations: 52
Parry MC, Bhabra G, Sood A, et al., 2010, Thresholds for indirect DNA damage across cellular barriers for orthopaedic biomaterials, BIOMATERIALS, Vol: 31, Pages: 4477-4483, ISSN: 0142-9612
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- Citations: 44
Cogan N, Baird DM, Phillips R, et al., 2010, DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr(VI) exposure and its dependence on telomerase, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol: 683, Pages: 1-8, ISSN: 0027-5107
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- Citations: 22
Newson RB, 2010, Frequentist q-values for multiple-test procedures, STATA JOURNAL, Vol: 10, Pages: 568-584, ISSN: 1536-867X
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- Citations: 97
Newson RB, 2010, Comparing the predictive powers of survival models using Harrell's C or Somers' D, STATA JOURNAL, Vol: 10, Pages: 339-358, ISSN: 1536-867X
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- Citations: 325
Minelli C, Granell R, Newson R, et al., 2009, Glutathione-S-transferase genes and asthma phenotypes: a Human Genome Epidemiology (HuGE) systematic review and meta-analysis including unpublished data, International Journal of Epidemiology, Vol: 39, Pages: 539-562, ISSN: 1464-3685
Background Oxidative stress is thought to be involved in the pathogenesis of asthma. Glutathione-S-transferase (GST) enzymes, which play an important role in antioxidant defences, may therefore influence asthma risk. Two common deletion polymorphisms of GSTM1 and GSTT1 genes and the GSTP1 Ile105Val polymorphism have been associated with asthma in children and adults, but results are inconsistent across studies.Methods Systematic review and meta-analysis of the effects of GST genes on asthma, wheezing and bronchial hyper-responsiveness (BHR), with inclusion of unpublished data from three studies, including the large Avon Longitudinal Study of Parents and Children (ALSPAC). Random effect or fixed effect models were used as appropriate, and sensitivity analyses were performed to assess the impact of study characteristics and quality on pooled results.Results The meta-analyses of GSTM1 (n = 22 studies) and GSTT1 (n = 19) showed increased asthma risk associated with the null genotype, but there was extreme between-study heterogeneity and publication bias and the association disappeared when meta-analysis was restricted to the largest studies. Meta-analysis of GSTP1 Ile105Val (n = 17) and asthma suggested a possible protective effect of the Val allele, but heterogeneity was extreme. Few studies evaluated wheezing and BHR and most reported no associations, although weak evidence was found for positive associations of GSTM1 null and GSTP1 Val allele with wheezing and a negative association of GSTP1 Val allele with BHR.Conclusions Our findings do not support a substantial role of GST genes alone in the development of asthma. Future studies of large size should focus on interactions of GST genes with environmental oxidative exposures and with other genes involved in antioxidant pathways. Quality of study conduct and reporting needs to be improved to increase credibility of the evidence accumulating over time.
Bhabra G, Sood A, Fisher B, et al., 2009, Nanoparticles can cause DNA damage across a cellular barrier, NATURE NANOTECHNOLOGY, Vol: 4, Pages: 876-883, ISSN: 1748-3387
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- Citations: 290
Shaheen SO, Northstone K, Newson RB, et al., 2009, Dietary patterns in pregnancy and respiratory and atopic outcomes in childhood, THORAX, Vol: 64, Pages: 411-417, ISSN: 0040-6376
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- Citations: 70
Glaviano A, Mothersill C, Case CP, et al., 2009, Effects of hTERT on genomic instability caused by either metal or radiation or combined exposure, MUTAGENESIS, Vol: 24, Pages: 25-33, ISSN: 0267-8357
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- Citations: 15
Papageorgiou I, Shadrick V, Davis S, et al., 2008, Macrophages detoxify the genotoxic and cytotoxic effects of surgical cobalt chrome alloy particles but not quartz particles on human cells in vitro, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol: 643, Pages: 11-19, ISSN: 0027-5107
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- Citations: 26
Burney PGJ, Newson RB, Burrows MS, et al., 2008, The effects of allergens in outdoor air on both atopic and nonatopic subjects with airway disease, ALLERGY, Vol: 63, Pages: 542-546, ISSN: 0105-4538
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- Citations: 13
Garcia-Larsen V, Newson RB, Potts JF, et al., 2007, Dietary intake of fruit and childhood asthma, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A21-A21, ISSN: 0040-6376
Forbes L, Harvey S, Newson R, et al., 2007, Risk factors for accident and emergency (A&E) attendance for asthma in inner city children, THORAX, Vol: 62, Pages: 855-860, ISSN: 0040-6376
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- Citations: 15
Shaheen SO, Newson RB, Holloway JW, et al., 2007, Maternal and child glutathione-S-transferase M1 polymorphism modifies risk of childhood asthma associated with prenatal paracetamol exposure, EARLY HUMAN DEVELOPMENT, Vol: 83, Pages: S59-S60, ISSN: 0378-3782
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- Citations: 1
Henderson AJ, Newson RB, Holloway JW, et al., 2007, Maternal and child glutathione-S-transferase M1 and T1 polymorphisms modify effect of maternal smoking in pregnancy on childhood lung function, EARLY HUMAN DEVELOPMENT, Vol: 83, Pages: S97-S97, ISSN: 0378-3782
Hutchinson M, Gurney S, Newson R, 2007, GDNF in Parkinson disease: An object lesson in the tyranny of type II, JOURNAL OF NEUROSCIENCE METHODS, Vol: 163, Pages: 190-192, ISSN: 0165-0270
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- Citations: 19
Papageorgiou I, Brown C, Schins R, et al., 2007, The effect of nano- and micron-sized particles of cobalt-chromium alloy on human fibroblasts in vitro, BIOMATERIALS, Vol: 28, Pages: 2946-2958, ISSN: 0142-9612
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- Citations: 286
Papageorgiou I, Yin Z, Ladon D, et al., 2007, Genotoxic effects of particles of surgical cobalt chrome alloy on human cells of different age in vitro, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol: 619, Pages: 45-58, ISSN: 0027-5107
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- Citations: 65
Okoko BJ, Burney PG, Newson RB, et al., 2007, Childhood asthma and fruit consumption, EUROPEAN RESPIRATORY JOURNAL, Vol: 29, Pages: 1161-1168, ISSN: 0903-1936
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- Citations: 44
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