Imperial College London

DrRichardNicholas

Faculty of MedicineDepartment of Brain Sciences

Professor of Practice (Neurology)
 
 
 
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r.nicholas

 
 
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12L12CLab BlockCharing Cross Campus

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Summary

 

Publications

Publication Type
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223 results found

Roever C, Nicholas R, Straube S, Friede Tet al., 2015, Changing EDSS Progression in Placebo Cohorts in Relapsing MS: A Systematic Review and Meta-Regression, PLOS One, Vol: 10, ISSN: 1932-6203

BackgroundRecent systematic reviews of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS) revealed a decrease in placebo annualized relapse rates (ARR) over the past two decades. Furthermore, regression to the mean effects were observed in ARR and MRI lesion counts. It is unclear whether disease progression measured by the expanded disability status scale (EDSS) exhibits similar features.MethodsA systematic review of RCTs in RMS was conducted extracting data on EDSS and baseline characteristics. The logarithmic odds of disease progression were modelled to investigate time trends. Random-effects models were used to account for between-study variability; all investigated models included trial duration as a predictor to correct for unequal study durations. Meta-regressions were conducted to assess the prognostic value of a number of study-level baseline variables.ResultsThe systematic literature search identified 39 studies, including a total of 19,714 patients. The proportion of patients in placebo controls experiencing a disease progression decreased over the years (p<0.001). Meta-regression identified associated covariates including the size of the study and its duration that in part explained the time trend. Progression probabilities tended to be lower in the second year of a study compared to the first year with a reduction of 28% in progression odds from year 1 to year 2 (p = 0.017).ConclusionEDSS disease progression exhibits similar behaviour over time as the ARR and point to changes in trial characteristics over the years. This needs to be considered in comparisons between historical and recent trials.

Journal article

Nicholas R, Raffel J, Malik O, 2015, Progressive multifocal leukoencephalopathy presenting with posterior fossa radiological features in the context of natalizumab therapy in relapsing-remitting multiple sclerosis, 31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 585-585, ISSN: 1352-4585

Conference paper

Scalfari A, Lederer C, Daumer M, Nicholas R, Ebers G, Muraro Pet al., 2015, The influence of age on the disease phenotype preceding the onset of progressive multiple sclerosis, 1st Congress of the European-Academy-of-Neurology, Publisher: WILEY, Pages: 301-301, ISSN: 1351-5101

Conference paper

Scalfari A, Ebers G, Nicholas R, Muraro P, Calabrese Met al., 2015, Frequent early relapses and severe cortical damage characterize patients at high risk of early developing progressive multiple sclerosis, 1st Congress of the European-Academy-of-Neurology, Publisher: WILEY, Pages: 620-620, ISSN: 1351-5101

Conference paper

Nicholas RS, Kostadima V, Hanspal M, Wakerley BR, Sergeant R, Decuypere S, Malik O, Boyton RJ, Altmann DMet al., 2015, MS in South Asians in England: early disease onset and novel pattern of myelin autoimmunity., BMC Neurology, Vol: 15, ISSN: 1471-2377

BACKGROUND: Epidemiological studies describe a latitude gradient for increased MS prevalence and a preponderance of disease in Caucasian individuals. However, individuals from other ethnic backgrounds and low-risk regions can acquire a raised risk through migration. Nearly a fifth of the London population is of Asian/Asian-British origin and a significant proportion of referrals are from this group. METHODS: We investigated whether there were differences in timing, presentation, severity, and immunology of disease (with respect to CD4 myelin epitope recognition) between individuals in London with MS who were either of S. Asian or Caucasian origin. Individuals of S. Asian origin with MS were compared with healthy S. Asian controls, individuals with MS and of Caucasian origin and Caucasian controls. RESULTS: Age at MS onset is significantly lower in the S. Asian group, attributable to earlier onset specifically in UK-born individuals, though clinical presentation is similar. Analysis of CD4 autoimmunity to myelin antigens shows disease in S. Asian individuals to encompass recognition of novel epitopes; immunity to MBP116-130 in S. Asian individuals was highly disease-specific. CONCLUSIONS: These findings emphasize the need to define disease profiles across ethnicities and identify environmental triggers conferring acquired risk. Such findings must inform choices for immunotherapeutic interventions suitable for all, across ethnicities.

Journal article

Mattoscio M, Nicholas R, Sormani MP, Malik O, Lee JS, Waldman AD, Dazzi F, Muraro PAet al., 2015, Hematopoietic mobilization Potential biomarker of response to natalizumab in multiple sclerosis, NEUROLOGY, Vol: 84, Pages: 1473-1482, ISSN: 0028-3878

Journal article

Clay J, Kelsey P, Bell S, Lim C, Helen J, Nicholas R, Silber E, Malik O, Brex P, Muraro P, Sharrack B, Snowden J, Kazmi Met al., 2015, Autologous haematopoietic stem cell transplantation in aggressive multiple sclerosis: a UK cohort from two centres, 41st Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S61-S61, ISSN: 0268-3369

Conference paper

Giovannonin G, de Jong B, Derfuss T, Izquierdo G, Mazibrada G, Molyneux P, Nicholas R, Overell J, Ziemssen T, Juliusson Get al., 2015, A pragmatic approach to dealing with fingolimod-related lynnphopaenia in Europe, MULTIPLE SCLEROSIS AND RELATED DISORDERS, Vol: 4, Pages: 83-84, ISSN: 2211-0348

Journal article

Sousa ADPA, Malmegrim KCR, Panepucci RA, Brum DS, Barreira AA, Dos Santos AC, Araujos AG, Covas DT, Oliveira MC, Moraes DA, Pieroni F, Barros GM, Simoes BP, Nicholas R, Burt RK, Voltarelli JC, Muraro PAet al., 2015, Autologous haematopoietic stem cell transplantation reduces abnormalities in the expression of immune genes in multiple sclerosis, CLINICAL SCIENCE, Vol: 128, Pages: 111-U57, ISSN: 0143-5221

Journal article

Nicholas RS, Friede T, Hollis S, Young CAet al., 2015, Anticholinergics for urinary symptoms in multiple sclerosis (Withdrawn Paper. 2015, Art. no. CD004193), COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X

Journal article

Giannetti P, Politis M, Su P, Turkheimer FE, Malik O, Keihaninejad S, Wu K, Waldman A, Reynolds R, Nicholas R, Piccini Pet al., 2014, Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome, Brain, Vol: 138, Pages: 110-119, ISSN: 0006-8950

Journal article

Sousa ADPA, Nicholas R, Johnson K, Darko S, Price D, Douek D, Muraro P, Jacobson Set al., 2014, Deep sequencing of T-cell receptor repertoire reveals enrichment of highly expanded clonotypes in cerebrospinal fluid from multiple sclerosis, 12th International Congress of Neuroimmunology (ISNI), Publisher: ELSEVIER SCIENCE BV, Pages: 197-198, ISSN: 0165-5728

Conference paper

Nicholas R, Barkhof F, Cohen J, Radue E-W, Kappos L, Haering D, Sfikas N, von Rosenstiel P, Francis Get al., 2014, BRAIN VOLUME CHANGE AND DISABILITY IN FINGOLIMOD TRIALS, Annual Meeting of the Association-of-British-Neurologists, Publisher: BMJ PUBLISHING GROUP, ISSN: 0022-3050

Conference paper

Sousa ADPA, Nicholas R, Johnson K, Darko S, Price D, Douek DC, Jacobson S, Muraro PAet al., 2014, Deep sequencing of T-cell receptor repertoire reveals enrichment of highly expanded clonotypes in cerebrospinal fluid from multiple sclerosis patients, Joint ACTRIMS-ECTRIMS Meeting, Publisher: SAGE PUBLICATIONS LTD, Pages: 57-57, ISSN: 1352-4585

Conference paper

Raffel J, Nicholas R, Roncaroli F, Reynolds Ret al., 2014, Astrocytes upregulate interleukin-17 receptor expression in white matter lesions in multiple sclerosis, Joint ACTRIMS-ECTRIMS Meeting, Publisher: SAGE PUBLICATIONS LTD, Pages: 366-367, ISSN: 1352-4585

Conference paper

Colasanti A, Guo Q, Muhlert N, Giannetti P, Onega M, Newbould RD, Ciccarelli O, Rison S, Thomas C, Nicholas R, Muraro PA, Malik O, Owen DR, Piccini P, Gunn RN, Rabiner EA, Matthews PMet al., 2014, In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with F-18-PBR111 PET, JOURNAL OF NUCLEAR MEDICINE, Vol: 55, Pages: 1112-1118, ISSN: 0161-5505

Journal article

Chataway J, Schuerer N, Alsanousi A, Chan D, MacManus D, Hunter K, Anderson V, Bangham CRM, Clegg S, Nielsen C, Fox NC, Wilkie D, Nicholas JM, Calder VL, Greenwood J, Frost C, Nicholas Ret al., 2014, Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial, LANCET, Vol: 383, Pages: 2213-2221, ISSN: 0140-6736

Journal article

Giannetti P, Politis M, Su P, Turkheimer F, Malik O, Keihaninejad S, Wu K, Reynolds R, Nicholas R, Piccini Pet al., 2014, Microglia activation in multiple sclerosis black holes predicts outcome in progressive patients: An in vivo [(11)C](R)-PK11195-PET pilot study, NEUROBIOLOGY OF DISEASE, Vol: 65, Pages: 203-210, ISSN: 0969-9961

Journal article

Papadopoulos D, Antoniou N, Tsimaratou K, Mitsikostas DD, Gorgoulis V, Nicholas Ret al., 2014, A quantitative histopathological study of the effects of arsenic oxides on inflammation, demyelination and neurodegeneration in multiple sclerosis, Joint Congress of European Neurology, Publisher: WILEY-BLACKWELL, Pages: 677-677, ISSN: 1351-5101

Conference paper

Papadopoulos D, Antoniou N, Tsimaratou K, Mitsikostas DD, Gorgoulis V, Nicholas Ret al., 2014, A quantitative histopathological study of the effects of arsenic oxides on inflammation, demyelination and neurodegeneration in multiple sclerosis, Joint Congress of European Neurology, Publisher: SPRINGER HEIDELBERG, Pages: S438-S438, ISSN: 0340-5354

Conference paper

Newbould RD, Nicholas R, Thomas CL, Quest R, Lee JSZ, Honeyfield L, Colasanti A, Malik O, Mattoscio M, Matthews PM, Sormani MP, Waldman AD, Muraroc PAet al., 2014, Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis, NeuroImage: Clinical, Vol: 4, Pages: 641-648, ISSN: 2213-1582

BackgroundMultiple sclerosis (MS) is a heterogeneous disorder with a progressive course that is difficult to predict on a case-by-case basis. Natural history studies of MS have demonstrated that age influences clinical progression independent of disease duration.ObjectiveTo determine whether age would be associated with greater CNS injury as detected by magnetization transfer MRI.Materials and methodsForty MS patients were recruited from out-patient clinics into two groups stratified by age but with similar clinical disease duration as well as thirteen controls age-matched to the older MS group. Images were segmented by automated programs and blinded readers into normal appearing white matter (NAWM), normal appearing gray matter (NAGM), and white matter lesions (WMLs) and gray matter lesions (GMLs) in the MS groups. WML and GML were delineated on T2-weighted 3D fluid-attenuated inversion recovery (FLAIR) and T1 weighted MRI volumes. Mean magnetization transfer ratio (MTR), region volume, as well as MTR histogram skew and kurtosis were calculated for each region.ResultsAll MTR measures in NAGM and MTR histogram metrics in NAWM differed between MS subjects and controls, as expected and previously reported by several studies, but not between MS groups. However, MTR measures in the WML did significantly differ between the MS groups, in spite of no significant differences in lesion counts and volumes.ConclusionsDespite matching for clinical disease duration and recording no significant WML volume difference, we demonstrated strong MTR differences in WMLs between younger and older MS patients. These data suggest that aging-related processes modify the tissue response to inflammatory injury and its clinical outcome correlates in MS.

Journal article

Raffel JB, Malik O, Nicholas RS, 2014, Assessing dalfampridine efficacy in the physician's office, MULTIPLE SCLEROSIS JOURNAL, Vol: 20, Pages: 24-26, ISSN: 1352-4585

Journal article

Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg JR, Hintzen R, Barcellos LF, Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Sondergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TMC, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BAC, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara I, Esposito F, Evangelou N, Fiddes B, Field J, Franke A, Freeman C, Frohlich IY, Galimberti D, Gieger C, Gourraud P-A, Graetz C, Graham A, Grummel V, Guaschino C, Hadjixenofontos A, Hakonarson H, Halfpenny C, Hall G, Hall P, Hamsten A, Harley J, Harrower T, Hawkins C, Hellenthal G, Hillier C, Hobart J, Hoshi M, Hunt SE, Jagodic M, Jelcic I, Jochim A, Kendall B, Kermode A, Kilpatrick T, Koivisto K, Konidari I, Korn T, Kronsbein H, Langford C, Larsson M, Lathrop M, Lebrun-Frenay C, Lechner-Scott J, Lee MH, Leone MA, Leppa V, Liberatore G, Lie BA, Lill CM, Linden M, Link J, Luessi F, Lycke J, Macciardi F, Mannisto S, Manrique CP, Martin R, Martinelli V, Mason D, Mazibrada G, McCabe C, Mero I-L, Mescheriakova J, Moutsianas L, Myhr K-M, Nagels G, Nicholas R, Nilsson P, Piehl F, Pirinen M, Price SE, Quach H, Reunanen M, Robberecht W, Robertson NP, Rodegher M, Rog D, Salvetti M, Schnetz-Boutaud NC, Sellebjerg F, Selter RC, Schaefer C, Shaunak S, Shen L, Shields S, Siffrin V, Slee M, Sorensen PS, Sorosina M, Sospedra M, Spurkland A, Strange A, Sundqvist E, Thijs V, Thorpe J, Ticca A, Tienari P, van Duijn C, Visser EM, Vucic Set al., 2013, Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis, NATURE GENETICS, Vol: 45, Pages: 1353-+, ISSN: 1061-4036

Journal article

Grew T, Merrett A, Malik O, Perry R, Nicholas R, Langdon Det al., 2013, A two-year longitudinal study of cognitive variant multiple sclerosis, 29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS, Publisher: SAGE PUBLICATIONS LTD, Pages: 58-59, ISSN: 1352-4585

Conference paper

Colasanti A, Guo Q, Mulhert N, Giannetti P, Onega M, Ciccarelli O, Nicholas R, Muraro P, Malik O, Owen DR, Piccini P, Gunn RN, Rabiner ER, Matthews PMet al., 2013, [18F]PBR111 binding in lesional and peri-lesional multiple sclerosis white matter, 29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS, Publisher: SAGE PUBLICATIONS LTD, Pages: 68-69, ISSN: 1352-4585

Conference paper

Steinvorth SM, Roever C, Schneider S, Nicholas R, Straube S, Friede Tet al., 2013, Explaining temporal trends in annualised relapse rates in placebo groups of randomised controlled trials in relapsing multiple sclerosis: systematic review and meta-regression, MULTIPLE SCLEROSIS JOURNAL, Vol: 19, Pages: 1580-1586, ISSN: 1352-4585

Journal article

Roever C, Nicholas R, Steinvorth S, Straube S, Friede Tet al., 2013, Comparison of disability scores and annualised relapse rates as trial outcomes in randomized, placebo controlled trials in relapsing multiple sclerosis: a systematic review, 29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS, Publisher: SAGE PUBLICATIONS LTD, Pages: 498-499, ISSN: 1352-4585

Conference paper

Nicholas R, Rashid W, 2013, Multiple sclerosis., Am Fam Physician, Vol: 87, Pages: 712-714

Journal article

Nicholas R, Rashid W, 2013, Multiple Sclerosis, AMERICAN FAMILY PHYSICIAN, Vol: 87, Pages: 712-714, ISSN: 0002-838X

Journal article

Ali R, Nicholas RSJ, Muraro PA, 2013, Drugs in Development for Relapsing Multiple Sclerosis, DRUGS, Vol: 73, Pages: 625-650, ISSN: 0012-6667

Journal article

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