Imperial College London

DrRichardNicholas

Faculty of MedicineDepartment of Brain Sciences

Professor of Practice (Neurology)
 
 
 
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Contact

 

r.nicholas

 
 
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Location

 

12L12CLab BlockCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

230 results found

Chataway J, Nicholas R, Stallard N, Todd S, Parsons N, Valdes-Marquez E, Friede Tet al., 2009, DEVELOPING A NEW TRIAL DESIGN IN SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS: A SEAMLESS ADAPTIVE APPROACH, ABN Joint Annual Meeting/Spanish-Society-of-Neurology, Publisher: B M J PUBLISHING GROUP, ISSN: 0022-3050

Conference paper

Chataway J, Nicholas R, Todd S, Stallard N, Valdes-Marquez E, Parsons N, Friede Tet al., 2009, Adaptive seamless trial designs in neurology: a case study in secondary progressive multiple sclerosis, 19th World Congress of Neurology, Publisher: ELSEVIER SCIENCE BV, Pages: S113-S114, ISSN: 0022-510X

Conference paper

Nicholas R, Chataway J, Todd S, Stallard N, Valdes-Marquez E, Parsons N, Friede Tet al., 2009, Adaptive clinical trials incorporating treatment selection and evaluation: methodology and application in progressive multiple sclerosis, 25th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S142-S143, ISSN: 1352-4585

Conference paper

Magliozzi R, Howell OW, Durrenberger PF, Nicholas R, Roncaroli F, Aloisi F, Reynolds Ret al., 2009, Cell and molecular changes in the grey matter of secondary progressive multiple sclerosis cases in response to meningeal inflammation, 25th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S174-S174, ISSN: 1352-4585

Conference paper

Howell OW, Reeves C, Magliozzi R, Carassiti D, Nicholas R, Radotra B, Gentlemen S, Roncaroli F, Aloisi F, Reynolds Ret al., 2009, The incidence of meningeal B-cell follicles in secondary progressive multiple sclerosis: a neuropathological study of 96 cases, 25th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S5-S5, ISSN: 1352-4585

Conference paper

Nicholas R, Chataway J, 2009, Multiple sclerosis., BMJ Clin Evid, Vol: 2009

INTRODUCTION: Multiple sclerosis is the most common cause of neurological disability in young adults. Irreversible disability can occur, but life expectancy is generally not affected. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of interventions aimed at reducing relapse rates and disability in people with multiple sclerosis? What are the effects of interventions to improve symptoms during acute relapse? What are the effects of treatments for fatigue, spasticity, and multidisciplinary care on disability in people with multiple sclerosis? We searched: Medline, Embase, The Cochrane Library, and other important databases up to June 2008 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 68 systematic reviews, RCTs, and observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review, we present information relating to the effectiveness and safety of the following key interventions: amantadine, azathioprine, behaviour modification, botulinum toxin, corticosteroids, exercise, gabapentin, inpatient or outpatient rehabilitation, interferon beta, intrathecal baclofen, intravenous immunoglobulin, methotrexate, mitoxantrone, modafinil, natalizumab, oral drug treatments, parenteral glatiramer acetate, physiotherapy, and plasma exchange.

Journal article

Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran Set al., 2009, Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis, ACTA NEUROPATHOLOGICA, Vol: 117, Pages: 583-589, ISSN: 0001-6322

Journal article

Papadopoulos D, Dukes S, Patel R, Nicholas R, Vora A, Reynolds Ret al., 2009, Substantial Archaeocortical Atrophy and Neuronal Loss in Multiple Sclerosis, BRAIN PATHOLOGY, Vol: 19, Pages: 238-253, ISSN: 1015-6305

Journal article

Mills RJ, Young CA, Nicholas RS, Pallant JF, Tennant Aet al., 2009, Rasch analysis of the Fatigue Severity Scale in multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 15, Pages: 81-87, ISSN: 1352-4585

Journal article

Nicholas RS, Friede T, Hollis S, Young CAet al., 2009, Anticholinergics for urinary symptoms in multiple sclerosis, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X

Journal article

Magliozzi R, Howell OW, Durrenberger PF, Roncacroli F, Nicholas R, Aloisi F, Reynolds Ret al., 2008, Substantial neuronal loss and microglia activation in MS grey matter are associated with increased meningeal inflammation, BrainNet Europe 2nd International Conference on Human Brain Tissue Research, Publisher: SPRINGER WIEN, Pages: 1731-1731, ISSN: 0300-9564

Conference paper

Gveric D, Nicholas R, Roncaroli F, Gentleman S, Reynolds Ret al., 2008, The UK multiple sclerosis tissue bank: target validation made easy, BrainNet Europe 2nd International Conference on Human Brain Tissue Research, Publisher: SPRINGER WIEN, Pages: 1731-1731, ISSN: 0300-9564

Conference paper

Reynolds R, Magliozzi R, Nicholas R, Roncaroli F, Durrenberger P, Serafini B, Aloisi F, Howell Oet al., 2008, Cortical pathology in multiple sclerosis is associated with substantial neurodegeneration and progressive neurological disability, BrainNet Europe 2nd International Conference on Human Brain Tissue Research, Publisher: SPRINGER WIEN, Pages: 1718-1719, ISSN: 0300-9564

Conference paper

Nicholas R, Magliozzi R, Mahad D, Polito A, Roncaroli F, Reynolds Ret al., 2008, Diffuse mitochondrial and neuronal damage ill the temporal cortex of multiple sclerosis patients is associated with increased occurrence of seizures, 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S275-S275, ISSN: 1352-4585

Conference paper

Scalfari A, Degenhardt A, Neuhaus A, Harner N, Seemueller S, Nicholas R, Mularo PA, Daumer M, Ebers Get al., 2008, The role of relapses affecting the long-term disability outcome in multiple sclerosis in the London Ontario database, 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S198-S198, ISSN: 1352-4585

Conference paper

Howell OW, Magliozzi R, Nicholas R, Roncaroli F, Aloisi F, Reynolds Ret al., 2008, Substantial pyramidal cell loss in the motor cortex of secondary progressive multiple sclerosis cases with meningeal B-cell follicles, 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S272-S273, ISSN: 1352-4585

Conference paper

Gveric D, Nicholas R, Roncaroli F, Gentleman S, Reynolds Ret al., 2008, The UK Multiple Sclerosis Tissue Bank: resource for research, 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S272-S272, ISSN: 1352-4585

Conference paper

Chataway J, Chan D, Anderson V, Polito B, Kallis C, Frost C, Calder V, Greenwood J, Nicholas Ret al., 2008, The MS-STAT trial: a Phase II trial of high dose simvastatin in secondary progressive multiple sclerosis, 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S36-S37, ISSN: 1352-4585

Conference paper

Balaratnam M, Adib-Sami P, D'Arcy C, Nicholas RS, Malik Oet al., 2008, Community based disciplinary multiple sclerosis clinics reduce hospital bed occupancy and enhance patient satisfaction, Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 339-340, ISSN: 0022-3050

Conference paper

Dukes SON, Patel R, Papadopoulos D, Vora A, Nicholas RS, Reynolds Ret al., 2008, Archaeocortical lesions in multiple sclerosis: A quantitive histopathological study, Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 339-339, ISSN: 0022-3050

Conference paper

Magliozzi R, Howell O, Nicholas R, Fernando F, Serafini B, Aloisi F, Reynolds Ret al., 2007, Extensive cortical cell loss is associated with the presence of meningeal B-cell follicles in secondary progressive multiple sclerosis, 23rd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/12th Annual Conference of Rehabilitation in MS, Publisher: SAGE PUBLICATIONS LTD, Pages: S16-S17, ISSN: 1352-4585

Conference paper

Nicholas RS, Polito A, Magliozzi R, Roncaroli F, Vora A, Gentleman SM, Malik O, Reynolds Ret al., 2007, Seizures in multiple sclerosis: a clinico-pathological study, 23rd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/12th Annual Conference of Rehabilitation in MS, Publisher: SAGE PUBLICATIONS LTD, Pages: S142-S142, ISSN: 1352-4585

Conference paper

Mills RJ, Vora AJ, Reynolds R, Nicholas RSet al., 2007, Predicting disability in multiple sclerosis using the MSIS-29, 23rd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/12th Annual Conference of Rehabilitation in MS, Publisher: SAGE PUBLICATIONS LTD, Pages: S117-S117, ISSN: 1352-4585

Conference paper

Dukes SON, Papadopoulos D, Nicholas R, Vora AJ, Reynolds Ret al., 2007, The hippocampus in multiple sclerosis: evidence of atrophy and neuronal loss, 23rd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/12th Annual Conference of Rehabilitation in MS, Publisher: SAGE PUBLICATIONS LTD, Pages: S141-S141, ISSN: 1352-4585

Conference paper

Nicholas RS, Magliozzi R, Howell O, Vora A, Serafini B, Puopolo M, Reynolds R, Aloisi Fet al., 2007, Meningeal B cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology, ABN Spring Scientific Meeting 2007, Publisher: B M J PUBLISHING GROUP, Pages: 1032-1032, ISSN: 0022-3050

Conference paper

Mills RJ, Nicholas R, Malik O, Young CAet al., 2007, Rasch analysis of the Modified Fatigue Impact Scale in multiple sclerosis, ABN Spring Scientific Meeting 2007, Publisher: B M J PUBLISHING GROUP, Pages: 1034-1034, ISSN: 0022-3050

Conference paper

Mills RJ, Nicholas RS, Malik O, Young CAet al., 2007, Rasch analysis of the fatigue severity scale in multiple sclerosis, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 14, Pages: 285-285, ISSN: 1351-5101

Journal article

Mills RJ, Nicholas RS, Malik O, Young CAet al., 2007, Rasch analysis of the fatigue severity scale in multiple sclerosis, 11th Congress of the European-Federation-of-Neurological-Societies, Pages: 285-285

Conference paper

Magliozzi R, Howell O, Vora A, Serafini B, Nicholas R, Puopolo M, Reynolds R, Aloisi Fet al., 2007, Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology, BRAIN, Vol: 130, Pages: 1089-1104, ISSN: 0006-8950

Journal article

Wakerley B, Jacob A, Ramtahal J, Rashid S, Polito B, Chataway J, Young C, Boggild M, Malik O, Nicholas Ret al., 2006, Population characteristics may contribute to the success or failure of disease modifying therapy in multiple sclerosis, Spring Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 1389-1389, ISSN: 0022-3050

Conference paper

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