Imperial College London

DrRichardNicholas

Faculty of MedicineDepartment of Brain Sciences

Professor of Practice (Neurology)
 
 
 
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Contact

 

r.nicholas

 
 
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Location

 

12L12CLab BlockCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

223 results found

Papadopoulos D, Dukes S, Patel R, Nicholas R, Vora A, Reynolds Ret al., 2009, Substantial Archaeocortical Atrophy and Neuronal Loss in Multiple Sclerosis, BRAIN PATHOLOGY, Vol: 19, Pages: 238-253, ISSN: 1015-6305

Journal article

Mills RJ, Young CA, Nicholas RS, Pallant JF, Tennant Aet al., 2009, Rasch analysis of the Fatigue Severity Scale in multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 15, Pages: 81-87, ISSN: 1352-4585

Journal article

Nicholas RS, Friede T, Hollis S, Young CAet al., 2009, Anticholinergics for urinary symptoms in multiple sclerosis, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X

Journal article

Magliozzi R, Howell OW, Durrenberger PF, Roncacroli F, Nicholas R, Aloisi F, Reynolds Ret al., 2008, Substantial neuronal loss and microglia activation in MS grey matter are associated with increased meningeal inflammation, BrainNet Europe 2nd International Conference on Human Brain Tissue Research, Publisher: SPRINGER WIEN, Pages: 1731-1731, ISSN: 0300-9564

Conference paper

Gveric D, Nicholas R, Roncaroli F, Gentleman S, Reynolds Ret al., 2008, The UK multiple sclerosis tissue bank: target validation made easy, BrainNet Europe 2nd International Conference on Human Brain Tissue Research, Publisher: SPRINGER WIEN, Pages: 1731-1731, ISSN: 0300-9564

Conference paper

Reynolds R, Magliozzi R, Nicholas R, Roncaroli F, Durrenberger P, Serafini B, Aloisi F, Howell Oet al., 2008, Cortical pathology in multiple sclerosis is associated with substantial neurodegeneration and progressive neurological disability, BrainNet Europe 2nd International Conference on Human Brain Tissue Research, Publisher: SPRINGER WIEN, Pages: 1718-1719, ISSN: 0300-9564

Conference paper

Nicholas R, Magliozzi R, Mahad D, Polito A, Roncaroli F, Reynolds Ret al., 2008, Diffuse mitochondrial and neuronal damage ill the temporal cortex of multiple sclerosis patients is associated with increased occurrence of seizures, 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S275-S275, ISSN: 1352-4585

Conference paper

Scalfari A, Degenhardt A, Neuhaus A, Harner N, Seemueller S, Nicholas R, Mularo PA, Daumer M, Ebers Get al., 2008, The role of relapses affecting the long-term disability outcome in multiple sclerosis in the London Ontario database, 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S198-S198, ISSN: 1352-4585

Conference paper

Howell OW, Magliozzi R, Nicholas R, Roncaroli F, Aloisi F, Reynolds Ret al., 2008, Substantial pyramidal cell loss in the motor cortex of secondary progressive multiple sclerosis cases with meningeal B-cell follicles, 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S272-S273, ISSN: 1352-4585

Conference paper

Gveric D, Nicholas R, Roncaroli F, Gentleman S, Reynolds Ret al., 2008, The UK Multiple Sclerosis Tissue Bank: resource for research, 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S272-S272, ISSN: 1352-4585

Conference paper

Chataway J, Chan D, Anderson V, Polito B, Kallis C, Frost C, Calder V, Greenwood J, Nicholas Ret al., 2008, The MS-STAT trial: a Phase II trial of high dose simvastatin in secondary progressive multiple sclerosis, 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S36-S37, ISSN: 1352-4585

Conference paper

Balaratnam M, Adib-Sami P, D'Arcy C, Nicholas RS, Malik Oet al., 2008, Community based disciplinary multiple sclerosis clinics reduce hospital bed occupancy and enhance patient satisfaction, Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 339-340, ISSN: 0022-3050

Conference paper

Dukes SON, Patel R, Papadopoulos D, Vora A, Nicholas RS, Reynolds Ret al., 2008, Archaeocortical lesions in multiple sclerosis: A quantitive histopathological study, Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 339-339, ISSN: 0022-3050

Conference paper

Magliozzi R, Howell O, Nicholas R, Fernando F, Serafini B, Aloisi F, Reynolds Ret al., 2007, Extensive cortical cell loss is associated with the presence of meningeal B-cell follicles in secondary progressive multiple sclerosis, 23rd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/12th Annual Conference of Rehabilitation in MS, Publisher: SAGE PUBLICATIONS LTD, Pages: S16-S17, ISSN: 1352-4585

Conference paper

Nicholas RS, Polito A, Magliozzi R, Roncaroli F, Vora A, Gentleman SM, Malik O, Reynolds Ret al., 2007, Seizures in multiple sclerosis: a clinico-pathological study, 23rd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/12th Annual Conference of Rehabilitation in MS, Publisher: SAGE PUBLICATIONS LTD, Pages: S142-S142, ISSN: 1352-4585

Conference paper

Mills RJ, Vora AJ, Reynolds R, Nicholas RSet al., 2007, Predicting disability in multiple sclerosis using the MSIS-29, 23rd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/12th Annual Conference of Rehabilitation in MS, Publisher: SAGE PUBLICATIONS LTD, Pages: S117-S117, ISSN: 1352-4585

Conference paper

Dukes SON, Papadopoulos D, Nicholas R, Vora AJ, Reynolds Ret al., 2007, The hippocampus in multiple sclerosis: evidence of atrophy and neuronal loss, 23rd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/12th Annual Conference of Rehabilitation in MS, Publisher: SAGE PUBLICATIONS LTD, Pages: S141-S141, ISSN: 1352-4585

Conference paper

Nicholas RS, Magliozzi R, Howell O, Vora A, Serafini B, Puopolo M, Reynolds R, Aloisi Fet al., 2007, Meningeal B cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology, ABN Spring Scientific Meeting 2007, Publisher: B M J PUBLISHING GROUP, Pages: 1032-1032, ISSN: 0022-3050

Conference paper

Mills RJ, Nicholas R, Malik O, Young CAet al., 2007, Rasch analysis of the Modified Fatigue Impact Scale in multiple sclerosis, ABN Spring Scientific Meeting 2007, Publisher: B M J PUBLISHING GROUP, Pages: 1034-1034, ISSN: 0022-3050

Conference paper

Mills RJ, Nicholas RS, Malik O, Young CAet al., 2007, Rasch analysis of the fatigue severity scale in multiple sclerosis, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 14, Pages: 285-285, ISSN: 1351-5101

Journal article

Mills RJ, Nicholas RS, Malik O, Young CAet al., 2007, Rasch analysis of the fatigue severity scale in multiple sclerosis, 11th Congress of the European-Federation-of-Neurological-Societies, Pages: 285-285

Conference paper

Magliozzi R, Howell O, Vora A, Serafini B, Nicholas R, Puopolo M, Reynolds R, Aloisi Fet al., 2007, Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology, BRAIN, Vol: 130, Pages: 1089-1104, ISSN: 0006-8950

Journal article

Wakerley B, Jacob A, Ramtahal J, Rashid S, Polito B, Chataway J, Young C, Boggild M, Malik O, Nicholas Ret al., 2006, Population characteristics may contribute to the success or failure of disease modifying therapy in multiple sclerosis, Spring Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: 1389-1389, ISSN: 0022-3050

Conference paper

Nicholas R, Vora A, Hobart JC, Malik O, Reynolds Ret al., 2006, The multiple sclerosis impact scale is sensitive to factors predictive of increasing severity of multiple sclerosis, 22nd Congress of the European-Committee-for-the-Treatment-and-Resarch-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S87-S87, ISSN: 1352-4585

Conference paper

Magliozzi R, Vora A, Serafini B, Nicholas R, Howell O, Puopolo M, Reynolds R, Aloisi Fet al., 2006, Pathological relevance of meningeal B-cell follicles in secondary progressive multiple sclerosis, 22nd Congress of the European-Committee-for-the-Treatment-and-Resarch-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S223-S224, ISSN: 1352-4585

Conference paper

Vora AJ, Nicholas RS, Malik O, Graeber M, Roncaroli F, Gentleman S, Reynolds Ret al., 2006, The UK Multiple Sclerosis Tissue Bank - a resource for research, JOURNAL OF NEURAL TRANSMISSION, Vol: 113, Pages: XIV-XIV, ISSN: 0300-9564

Journal article

Majed HH, Chandran S, Niclou SP, Nicholas RS, Wilkins A, Wing MG, Rhodes KE, Spillantini MG, Compston Aet al., 2006, A novel role for Sema3A in neuroprotection from injury mediated by activated microglia., J Neurosci, Vol: 26, Pages: 1730-1738

Microglia exist under physiological conditions in a resting state but become activated after neuronal injury. Recent studies have highlighted the reciprocal role of neurons in controlling both the number and activity of microglia. In this study, microglia derived from newborn rat cortices were cultured and activated by interferon-gamma (IFNgamma) treatment, then exposed to recombinant Sema3A or conditioned medium derived from stressed embryonic cortical neurons. We found that activation of microglia by IFNgamma induced differential upregulation of the semaphorin receptors Plexin-A1 and Neuropilin-1. This result was confirmed by Northern blotting, reverse transcription-PCR, and Western blotting. Furthermore, recombinant Sema3A induced apoptosis of microglia when added to the in vitro culture, and a similar result was obtained on activated microglia when Sema3A was produced by stressed neurons. Using an in vivo model of microglia activation by striatal injection of lipopolysaccharide demonstrated a corresponding upregulation of Plexin-A1 and Neuropilin-1 in activated microglia and enhanced production of Sema3A by stressed adult neurons. These results suggest a novel semaphorin-mediated mechanism of neuroprotection whereby stressed neurons can protect themselves from further damage by activated microglia.

Journal article

Jenkinson MD, Simpson C, Nicholas RS, Miles J, Findlay GFG, Pigott TJDet al., 2006, Outcome predictors and complications in the management of intradural spinal tumours., Eur Spine J, Vol: 15, Pages: 203-210, ISSN: 0940-6719

The results of the management of 115 patients with intradural spinal tumours are presented. Data was collected retrospectively from the case notes. Tumours were categorized as intramedullary or extramedullary for statistical analysis. Meningioma, schwannoma and ependymoma accounted for 70% of tumours. Complete macroscopic excision was achieved in 84% of extramedullary and 54% of intramedullary tumours. There were two post-operative deaths, one of which was secondary to methacillin-resistant staphylococcus aureus (MRSA) meningitis. Cerebrospinal fluid leak (10%) and meningitis (7%) were the commonest complications. Ninety-six percent of patients with extramedullary tumours improved or remained unchanged on the Frankel scale. In the intramedullary group, 82% remained unchanged or improved after treatment. Pre-operative functional status was a predictor of good post-operative function for intra- and extramedullary tumours and for intramedullary tumours a good post-operative Frankel score predicted long-term survival.

Journal article

Nicholas RS, Roncaroli F, Vora AJ, Gentleman SM, Graeber MB, Malik O, Reynolds Ret al., 2006, Seizures in multiple sclerosis (MS): Is grey matter damage the culprit?, Clinical Neurosciences 2005 Meeting, Publisher: B M J PUBLISHING GROUP, Pages: 140-140, ISSN: 0022-3050

Conference paper

Ford H, Nicholas R, 2005, Multiple sclerosis., Clin Evid, Pages: 1637-1651, ISSN: 1462-3846

Journal article

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