Imperial College London


Faculty of MedicineDepartment of Brain Sciences

Professor of Practice (Neurology)







12L12CLab BlockCharing Cross Campus






BibTex format

author = {Nicholas, RS and Stevens, S and Wing, MG and Compston, DA},
doi = {10.1016/s0165-5728(02)00011-5},
journal = {J Neuroimmunol},
pages = {36--44},
title = {Microglia-derived IGF-2 prevents TNFalpha induced death of mature oligodendrocytes in vitro.},
url = {},
volume = {124},
year = {2002}

RIS format (EndNote, RefMan)

AB - Insulin-like growth factor-2 (IGF-2) present in media conditioned by non-activated and interferon gamma (IFN gamma)-treated microglia reduces galactocerebroside(+) (GalC) oligodendrocyte apoptosis in cultures derived both from the CG4 cell line and primary rat cortices. Microglia-derived IGF-2 also acts in each culture system to block GalC(+) oligodendrocyte toxicity resulting from soluble microglial-derived tumour necrosis factor alpha (TNF alpha). IGF-2 inhibits TNF alpha-induced c-Jun kinase (JNK) activation of the CG4 cell line. Microglial activation results in the release of soluble factors that are potentially toxic to oligodendrocytes but this may be offset by the production of soluble factors that protect these vulnerable cells. Allowing for extrapolation of these in vitro findings to intact tissue, our observations suggest one mechanism for limiting bystander damage in the context of inflammatory brain disease.
AU - Nicholas,RS
AU - Stevens,S
AU - Wing,MG
AU - Compston,DA
DO - 10.1016/s0165-5728(02)00011-5
EP - 44
PY - 2002///
SN - 0165-5728
SP - 36
TI - Microglia-derived IGF-2 prevents TNFalpha induced death of mature oligodendrocytes in vitro.
T2 - J Neuroimmunol
UR -
UR -
VL - 124
ER -