Imperial College London


Faculty of MedicineDepartment of Brain Sciences

Professor of Practice (Neurology)







12L12CLab BlockCharing Cross Campus






BibTex format

author = {Nicholas, R and Stevens, S and Wing, M and Compston, A},
doi = {10.1097/01.wnr.0000068553.33086.4b},
journal = {Neuroreport},
pages = {1001--1005},
title = {Oligodendroglial-derived stress signals recruit microglia in vitro.},
url = {},
volume = {14},
year = {2003}

RIS format (EndNote, RefMan)

AB - Rat oligodendrocytes cultured without the essential survival factors serum and insulin die over a 48 h period. Analysis of supernatants from these dying cultures reveals a microglial chemokine released in advance of significant cell death. The observed microglial chemotactic effect is dose-dependent and not due to release of cellular debris. Interferon (IFN)-gamma activated microglia are more sensitive to the microglial chemokine. We show in co-culture that recruited non-activated microglia can enhance oligodendroglial survival whereas IFN-gamma activation of microglia induces contact-dependent oligodendroglial death. Thus, whilst the initial recruitment of microglia by stressed oligodendroglia may represent part of a survival process engaged by injured cells, this does not necessarily ensure survival.
AU - Nicholas,R
AU - Stevens,S
AU - Wing,M
AU - Compston,A
DO - 10.1097/01.wnr.0000068553.33086.4b
EP - 1005
PY - 2003///
SN - 0959-4965
SP - 1001
TI - Oligodendroglial-derived stress signals recruit microglia in vitro.
T2 - Neuroreport
UR -
UR -
VL - 14
ER -