Imperial College London

DrRichardNicholas

Faculty of MedicineDepartment of Brain Sciences

Professor of Practice (Neurology)
 
 
 
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Contact

 

r.nicholas

 
 
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Location

 

12L12CLab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wing:1999:10.1016/s0165-5728(98)00227-6,
author = {Wing, MG and Seilly, DJ and Nicholas, RS and Rahman, S and Zajicek, J and Lachmann, PJ and Compston, DA},
doi = {10.1016/s0165-5728(98)00227-6},
journal = {J Neuroimmunol},
pages = {74--81},
title = {Comparison of C1q-receptors on rat microglia and peritoneal macrophages.},
url = {http://dx.doi.org/10.1016/s0165-5728(98)00227-6},
volume = {94},
year = {1999}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - A comparison of the expression and ligand specificity of the C1q (first complement component) receptor on rat microglia and peritoneal macrophages was made. This revealed that radiolabelled C1q was competed from the peritoneal macrophages with intact C1q, and additively displaced by calf-skin collagen and purified C1q globular heads, suggesting the presence of at least two receptors. This was in contrast to microglia, where radiolabelled C1q was displaced with intact C1q and to a modest degree with collagen, but not with globular heads. Taken together, this implies that under these conditions, peritoneal macrophages and microglia both express a C1q receptor which binds to the collagen-like region, and that peritoneal macrophages additionally express a molecule which binds to the globular head of C1q. Analysis of the ligand bound by these cells reflected the differences observed in the competitive binding experiments, with the novel identification of naturally-occurring peptides from the globular head of C1q bound to the peritoneal macrophages, but not the microglia.
AU - Wing,MG
AU - Seilly,DJ
AU - Nicholas,RS
AU - Rahman,S
AU - Zajicek,J
AU - Lachmann,PJ
AU - Compston,DA
DO - 10.1016/s0165-5728(98)00227-6
EP - 81
PY - 1999///
SN - 0165-5728
SP - 74
TI - Comparison of C1q-receptors on rat microglia and peritoneal macrophages.
T2 - J Neuroimmunol
UR - http://dx.doi.org/10.1016/s0165-5728(98)00227-6
UR - https://www.ncbi.nlm.nih.gov/pubmed/10376938
VL - 94
ER -