Imperial College London

DrRichardNicholas

Faculty of MedicineDepartment of Brain Sciences

Professor of Practice (Neurology)
 
 
 
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Contact

 

r.nicholas

 
 
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Location

 

12L12CLab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Magliozzi:2018:10.1002/ana.25197,
author = {Magliozzi, R and Howell, OW and Nicholas, R and Cruciani, C and Castellaro, M and Romualdi, C and Rossi, S and Pitteri, M and Benedetti, MD and Gajofatto, A and Pizzini, FB and Montemezzi, S and Rasia, S and Capra, R and Bertoldo, A and Facchiano, F and Monaco, S and Reynolds, R and Calabrese, M},
doi = {10.1002/ana.25197},
journal = {Annals of Neurology},
pages = {739--755},
title = {Inflammatory intrathecal profiles and cortical damage in multiple sclerosis},
url = {http://dx.doi.org/10.1002/ana.25197},
volume = {83},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - OBJECTIVE: Grey matter (GM) damage and meningeal inflammation have been associated with early disease onset and a more aggressive disease course in Multiple Sclerosis (MS), but can these changes be identified in the patient early in the disease course? METHODS: To identify possible biomarkers linking meningeal inflammation, GM damage and disease severity, gene and protein expression were analysed in meninges and CSF from 27 post-mortem secondary progressive MS (SPMS) and 14 control cases. Combined cytokine/chemokine CSF profiling and 3T-MRI were performed at diagnosis in two independent cohorts of MS patients (35 and 38 subjects) and in 26 non-MS patients. RESULTS: Increased expression of pro-inflammatory cytokines (IFNγ, TNF, IL2 and IL22) and molecules related to sustained B-cell activity and lymphoid-neogenesis (CXCL13, CXCL10, LTα, IL6, IL10) was detected in the meninges and CSF of post-mortem MS cases with high levels of meningeal inflammation and GM demyelination. Similar pro-inflammatory patterns, including increased levels of CXCL13, TNF, IFNγ, CXCL12, IL6, IL8 and IL10, together with high levels of BAFF, APRIL, LIGHT, TWEAK, sTNFR1, sCD163, MMP2 and pentraxin III, were detected in the CSF of MS patients with higher levels of GM damage at diagnosis. INTERPRETATION: A common pattern of intrathecal (meninges and CSF) inflammatory profile strongly correlates with increased cortical pathology, both at time of the diagnosis and of death. These results suggest a role for detailed CSF analysis combined with MRI, as a prognostic marker for more aggressive MS. This article is protected by copyright. All rights reserved.
AU - Magliozzi,R
AU - Howell,OW
AU - Nicholas,R
AU - Cruciani,C
AU - Castellaro,M
AU - Romualdi,C
AU - Rossi,S
AU - Pitteri,M
AU - Benedetti,MD
AU - Gajofatto,A
AU - Pizzini,FB
AU - Montemezzi,S
AU - Rasia,S
AU - Capra,R
AU - Bertoldo,A
AU - Facchiano,F
AU - Monaco,S
AU - Reynolds,R
AU - Calabrese,M
DO - 10.1002/ana.25197
EP - 755
PY - 2018///
SN - 0364-5134
SP - 739
TI - Inflammatory intrathecal profiles and cortical damage in multiple sclerosis
T2 - Annals of Neurology
UR - http://dx.doi.org/10.1002/ana.25197
UR - https://www.ncbi.nlm.nih.gov/pubmed/29518260
UR - http://hdl.handle.net/10044/1/58588
VL - 83
ER -