Publications
385 results found
Kamel F, Ettorre A, Durrenberger PF, et al., 2011, Altered invariant natural killer T cells in multiple sclerosis, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 41-41, ISSN: 0019-2805
Ettorre A, Kamel FO, Durrenberger PF, et al., 2011, KIR expression as a biomarker of multiple sclerosis disease type, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 172-172, ISSN: 0019-2805
Howell O, Reeves C, Nicholas R, et al., 2011, Meningeal inflammation is widespread and linked to cortical pathology and an accelerated clinical course in secondary progressive multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: S39-S39, ISSN: 1352-4585
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- Citations: 1
Nicholas R, Straube S, Schmidli H, et al., 2011, Trends in annualized relapse rates in relapsing-remitting multiple sclerosis and consequences for clinical trial design, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: 1211-1217, ISSN: 1352-4585
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- Citations: 36
Wilkie D, Chataway J, Nicholas R, 2011, Regulation and oversight of independent investigator-led multiple sclerosis (MS) studies results in a 10-fold greater administrative workload for independent investigators compared to being an investigator in a pharmaceutical company-led MS trial, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: S466-S466, ISSN: 1352-4585
Mattoscio M, Nicholas R, Malik O, et al., 2011, Differential increase of circulating haematopoietic stem cells following therapeutic alpha 4-integrin blockade in multiple sclerosis: definition of mobilisers versus non-mobilisers subjects and clinical correlations, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: S191-S191, ISSN: 1352-4585
Howell OW, Reeves CA, Nicholas R, et al., 2011, Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis, BRAIN, Vol: 134, Pages: 2755-2771, ISSN: 0006-8950
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- Citations: 555
Chataway J, Awad M, Meadmore K, et al., 2011, COGNITIVE AND NEUROPSYCHIATRIC STATUS IN A LARGE COHORT OF PATIENTS WITH SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 82, ISSN: 0022-3050
Thapar A, Lane TRA, Pandey V, et al., 2011, Internal jugular thrombosis post venoplasty for chronic cerebrospinal venous insufficiency, PHLEBOLOGY, Vol: 26, Pages: 254-256, ISSN: 0268-3555
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- Citations: 17
Bentley P, Wang T, Malik O, et al., 2011, CADASIL with cord involvement associated with a novel and atypical NOTCH3 mutation, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 82, Pages: 855-860, ISSN: 0022-3050
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- Citations: 24
Reynolds R, Roncaroli F, Nicholas R, et al., 2011, The neuropathological basis of clinical progression in multiple sclerosis, ACTA NEUROPATHOLOGICA, Vol: 122, Pages: 155-170, ISSN: 0001-6322
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- Citations: 150
Friede T, Parsons N, Stallard N, et al., 2011, Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: An application in multiple sclerosis, 6th International Meeting on Statistical Methods in Biopharmacy, Publisher: WILEY, Pages: 1528-1540, ISSN: 0277-6715
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- Citations: 34
Giannetti P, Politis M, Su P, et al., 2011, Two different roles for microglia in vivo in T1 black holes in relapsing and progressive multiple sclerosis?, 21st Meeting of the European-Neurological-Society, Publisher: SPRINGER HEIDELBERG, Pages: 221-221, ISSN: 0340-5354
Wakerley BR, Nicholas RS, Malik OR, et al., 2011, The Effects of Disease Activity and Interferon-beta on Telomere Length and Telomerase Activity in Multiple Sclerosis, 63rd AAN Annual Meeting, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: A135-A135, ISSN: 0028-3878
Howell OW, Reeves C, Carassiti D, et al., 2011, The distribution of B-cell follicle-like structures in the cerebral meninges and their association with extensive inflammation and demyelination in multiple sclerosis, 112th Meeting of the British-Neuropathological-Society, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 27-27, ISSN: 0305-1846
Chataway J, Nicholas R, Todd S, et al., 2011, A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 17, Pages: 81-88, ISSN: 1352-4585
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- Citations: 35
Nicholas R, Giannetti P, Alsanousi A, et al., 2011, Development of oral immunomodulatory agents in the management of multiple sclerosis., Drug Des Devel Ther, Vol: 5, Pages: 255-274
The emergence of oral disease-modifying therapies in multiple sclerosis (MS) will have a significant impact on the evolving scenario of immunomodulatory treatments in MS where current therapies are all injectable. Reducing relapses in trials translates for individuals with MS into a therapeutic aim of stopping future events. Thus the possible absence of any perceived benefits to the individual together with the long disease course, variable outcome, and a younger age group affected in MS makes side effects the major issue. The use of disease-modifying therapies as a whole needs to be placed in the context of a widening therapeutic indication where the use of these therapies is being justified at an increasingly early stage and in pre-MS syndromes such as clinically isolated and radiologically isolated syndromes where no fixed disability is likely to have accumulated. The five oral therapies discussed (cladribine, fingolimod, laquinimod, BG-12, and teriflunomide) have just completed Phase III studies and some have just been licensed. New oral drugs for MS need to be placed within this evolving marketplace where ease of delivery together with efficacy and side effects needs to be balanced against the known issues but also the known long-term safety of standard injectables.
Harris AJ, Durrenberger P, Kamel F, et al., 2010, Investigating the role of natural killer cell subsets in multiple sclerosis, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 125-125, ISSN: 0019-2805
Nicholas R, D'Arcy C, Muraro P, et al., 2010, USING NATALIZUMAB IN HIGHLY ACTIVE RELAPSING REMITTING MULTIPLE SCLEROSIS IN THE UK, Annual Meeting of the Association-of-British-Neurologists, Publisher: B M J PUBLISHING GROUP, Pages: E53-E53, ISSN: 0022-3050
Friede T, Nicholas R, Stallard N, et al., 2010, Refinement of the Clinical Scenario Evaluation Framework for Assessment of Competing Development Strategies With an Application to Multiple Sclerosis, DRUG INFORMATION JOURNAL, Vol: 44, Pages: 713-718, ISSN: 0092-8615
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- Citations: 18
Nicholas R, Young C, Friede T, 2010, Bladder symptoms in multiple sclerosis: a review of pathophysiology and management, EXPERT OPINION ON DRUG SAFETY, Vol: 9, Pages: 905-915, ISSN: 1474-0338
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- Citations: 16
Magliozzi R, Howell OW, Reeves C, et al., 2010, A Gradient of Neuronal Loss and Meningeal Inflammation in Multiple Sclerosis, ANNALS OF NEUROLOGY, Vol: 68, Pages: 477-493, ISSN: 0364-5134
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- Citations: 493
Mattoscio M, Nicholas R, Malik O, et al., 2010, Functional relevance of haematopoietic stem cell mobilization following therapeutic α 4-integrin blockade in multiple sclerosis: preliminary data, 20th Meeting of the European-Neurological-Society, Publisher: SPRINGER HEIDELBERG, Pages: S221-S221, ISSN: 0340-5354
Anderson JM, Patani R, Reynolds R, et al., 2010, Abnormal tau phosphorylation in primary progressive multiple sclerosis, ACTA NEUROPATHOLOGICA, Vol: 119, Pages: 591-600, ISSN: 0001-6322
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- Citations: 26
Nicholas R, Radotra B, Roncaroli F, et al., 2010, Increasing Macroscopic Pathological Damage in Multiple Sclerosis (MS) Is Associated with More Severe Disease Milestones, 62nd Annual Meeting of the American-Academy-of-Neurology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: A365-A365, ISSN: 0028-3878
Politis M, Giannetti P, Su P, et al., 2010, Cortical Microglial Activation Is Associated with Disability in Secondary Progressive Multiple Sclerosis: An <i>In Vivo</i> Imaging Study, 62nd Annual Meeting of the American-Academy-of-Neurology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: A290-A290, ISSN: 0028-3878
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- Citations: 4
Marini-Bettolo C, Lane R, Charles P, et al., 2009, Myopathy secondary to intravascular large B-cell lymphoma, NEUROMUSCULAR DISORDERS, Vol: 19, Pages: 856-859, ISSN: 0960-8966
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- Citations: 1
Chataway J, Nicholas R, Stallard N, et al., 2009, DEVELOPING A NEW TRIAL DESIGN IN SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS: A SEAMLESS ADAPTIVE APPROACH, ABN Joint Annual Meeting/Spanish-Society-of-Neurology, Publisher: B M J PUBLISHING GROUP, ISSN: 0022-3050
Wakerley BR, Hanspall M, Malik O, et al., 2009, REASSESSING THE USE OF MITOXANTRONE IN MULTIPLE SCLEROSIS, ABN Joint Annual Meeting/Spanish-Society-of-Neurology, Publisher: B M J PUBLISHING GROUP, ISSN: 0022-3050
Chataway J, Nicholas R, Todd S, et al., 2009, Adaptive seamless trial designs in neurology: a case study in secondary progressive multiple sclerosis, 19th World Congress of Neurology, Publisher: ELSEVIER SCIENCE BV, Pages: S113-S114, ISSN: 0022-510X
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