Publications
385 results found
Choi S, Hill D, Guo L, et al., 2022, Automated characterisation of microglia in ageing mice using image processing and supervised machine learning algorithms, Scientific Reports, Vol: 12, ISSN: 2045-2322
The resident macrophages of the central nervous system, microglia, are becoming increasingly implicated as active participants in neuropathology and ageing. Their diverse and changeable morphology is tightly linked with functions they perform, enabling assessment of their activity through image analysis. To better understand the contributions of microglia in health, senescence, and disease, it is necessary to measure morphology with both speed and reliability. A machine learning approach was developed to facilitate automatic classification of images of retinal microglial cells as one of five morphotypes, using a support vector machine (SVM). The area under the receiver operating characteristic curve for this SVM was between 0.99 and 1, indicating strong performance. The densities of the different microglial morphologies were automatically assessed (using the SVM) within wholemount retinal images. Retinas used in the study were sourced from 28 healthy C57/BL6 mice split over three age points (2, 6, and 28-months). The prevalence of ‘activated’ microglial morphology was significantly higher at 6- and 28-months compared to 2-months (p < .05 and p < .01 respectively), and ‘rod’ significantly higher at 6-months than 28-months (p < 0.01). The results of the present study propose a robust cell classification SVM, and further evidence of the dynamic role microglia play in ageing.
Jacobs SAH, Muraro PA, Cencioni MT, et al., 2022, Worse Physical Disability Is Associated With the Expression of PD-1 on Inflammatory T-Cells in Multiple Sclerosis Patients With Older Appearing Brains, FRONTIERS IN NEUROLOGY, Vol: 12, ISSN: 1664-2295
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- Citations: 1
Garjani A, Middleton RM, Nicholas R, et al., 2022, Recovery From COVID-19 in Multiple Sclerosis: A Prospective and Longitudinal Cohort Study of the United Kingdom Multiple Sclerosis Register, NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, Vol: 9, ISSN: 2332-7812
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- Citations: 18
Das J, Rog DJ, Middleton R, et al., 2022, The association between deprivation and the access to disease modifying therapies for multiple sclerosis: An England wide community-based study in the UK MS Register, MULTIPLE SCLEROSIS AND RELATED DISORDERS, Vol: 57, ISSN: 2211-0348
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- Citations: 1
Simpson-Yap S, De Brouwer E, Kalincik T, et al., 2021, Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis, NEUROLOGY, Vol: 97, Pages: E1870-E1885, ISSN: 0028-3878
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- Citations: 101
Dobson R, Craner M, Waddingham E, et al., 2021, OPTIMISE: MS study protocol: a pragmatic, prospective observational study to address the need for, and challenges with, real world pharmacovigilance in multiple sclerosis, BMJ OPEN, Vol: 11, ISSN: 2044-6055
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- Citations: 3
Middleton RM, Craig EM, Rodgers WJ, et al., 2021, COVID-19 in Multiple Sclerosis: Clinically reported outcomes from the UK Multiple Sclerosis Register, MULTIPLE SCLEROSIS AND RELATED DISORDERS, Vol: 56, ISSN: 2211-0348
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- Citations: 6
Nicholas R, Rodgers J, Witts J, et al., 2021, Impact of first dose COVID-19 Pfizer and AstraZeneca vaccination in multiple sclerosis: a study from the UK MS Register, Publisher: SAGE PUBLICATIONS LTD, Pages: 221-222, ISSN: 1352-4585
Rodgers WJ, Middleton R, Witts J, et al., 2021, Efficacy of highly active disease modifying treatment versus interferon in multiple sclerosis: a UK MS register study, Publisher: SAGE PUBLICATIONS LTD, Pages: 612-612, ISSN: 1352-4585
Middleton R, Witts J, Knowles S, et al., 2021, Incidence and prevalence of multiple sclerosis (MS) in Wales - algorithmic case finding in routine data, Publisher: SAGE PUBLICATIONS LTD, Pages: 224-224, ISSN: 1352-4585
Forsberg L, Glaser A, Manouchehrinia A, et al., 2021, Contributors to secondary progressive multiple sclerosis conversion age - a federated learning analysis across five European MS registries, Publisher: SAGE PUBLICATIONS LTD, Pages: 201-202, ISSN: 1352-4585
Rodgers J, Witts J, Middleton R, et al., 2021, Treatment patterns in secondary progressive multiple sclerosis a multi-country registry study from five European countries, Publisher: SAGE PUBLICATIONS LTD, Pages: 138-139, ISSN: 1352-4585
Pisani AI, Magliozzi R, Romualdi C, et al., 2021, A pilot study: The identification of cerebrospinal fluid profile prognostic of secondary progression at diagnosis of relapsing-remitting multiple sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: 210-210, ISSN: 1352-4585
Dorsey-Campbell R, Karoui H, Delacruz D, et al., 2021, Blueteq data : EDSS scores in patients on disease modifying therapy at a single centre, Publisher: SAGE PUBLICATIONS LTD, Pages: 627-628, ISSN: 1352-4585
Dorsey-Campbell R, Jaku N, Parreno L, et al., 2021, Comparison of perceived and actual risks of progressive multifocal encephalopathy in patients treated with natalizumab at a single centre, Publisher: SAGE PUBLICATIONS LTD, Pages: 644-644, ISSN: 1352-4585
Tamanti A, Castellaro M, Pizzini FB, et al., 2021, Multimodal quantitative and semiquantitative MRI assessment of cortical grey matter demyelination: a neuropathology-MRI study, Publisher: SAGE PUBLICATIONS LTD, Pages: 417-418, ISSN: 1352-4585
Magliozzi R, Tamanti A, Castellaro M, et al., 2021, Combined MRI and neuropathology pattern characterization of subpial cortical lesion activity in multiple sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: 79-80, ISSN: 1352-4585
Picon C, Robertas A, Wojewska M, et al., 2021, Endosomal sorting complex III is dysregulated in cortical neurons in progressive MS and associated with necroptosis activation, Publisher: SAGE PUBLICATIONS LTD, Pages: 52-52, ISSN: 1352-4585
Huang Y, Rodgers WJ, Middleton RM, et al., 2021, Willingness to receive a COVID-19 vaccine in people with multiple sclerosis - UK MS Register survey, MULTIPLE SCLEROSIS AND RELATED DISORDERS, Vol: 55, ISSN: 2211-0348
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- Citations: 12
Simpson-Yap S, Pirmani A, De Brouwer E, et al., 2021, Updated results of the COVID-19 in MS global data sharing initiative validate consistent associations of anti-CD20 and other reported risk factors with severe COVID-19 outcomes, Publisher: SAGE PUBLICATIONS LTD, Pages: 741-743, ISSN: 1352-4585
Nicholas R, Nicholas E, Hannides M, et al., 2021, Influence of individual, illness and environmental factors on place of death among people with neurodegenerative diseases: a retrospective, observational, comparative cohort study, BMJ SUPPORTIVE & PALLIATIVE CARE, ISSN: 2045-435X
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- Citations: 4
Nicholas RS, Rhone EE, Mariottini A, et al., 2021, Autologous Hematopoietic Stem Cell Transplantation in Active Multiple Sclerosis, NEUROLOGY, Vol: 97, Pages: E890-E901, ISSN: 0028-3878
Pienaar IS, Mohammed R, Courtley R, et al., 2021, Investigation of the correlation between mildly deleterious mtDNA Variations and the clinical progression of multiple sclerosis, MULTIPLE SCLEROSIS AND RELATED DISORDERS, Vol: 53, ISSN: 2211-0348
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- Citations: 1
Cencioni MT, Ali R, Nicholas R, et al., 2021, Defective CD19+CD24<SUP>hi</SUP>CD38<SUP>hi</SUP>transitional B-cell function in patients with relapsing-remitting MS, MULTIPLE SCLEROSIS JOURNAL, Vol: 27, Pages: 1187-1197, ISSN: 1352-4585
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- Citations: 18
Garjani A, Middleton RM, Hunter R, et al., 2021, COVID-19 is associated with new symptoms of multiple sclerosis that are prevented by disease modifying therapies, MULTIPLE SCLEROSIS AND RELATED DISORDERS, Vol: 52, ISSN: 2211-0348
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- Citations: 23
Garjani A, Middleton RM, Nicholas R, et al., 2021, Pre-existing anxiety, depression, and neurological disability is associated with long COVID: A prospective and longitudinal cohort of the United Kingdom Multiple Sclerosis Register
<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Objectives</jats:title><jats:p>To assess the prevalence of long COVID among people with multiple sclerosis (MS) and its predictors, including their pre-COVID-19 functional status.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>Community-based prospective and longitudinal cohort study</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>The United Kingdom (UK) MS Register (UKMSR) COVID-19 study</jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p>A national cohort of people with MS and COVID-19</jats:p></jats:sec><jats:sec><jats:title>Main outcome measures</jats:title><jats:p>Participants used the online questionnaire-based platform of the UKMSR to update their COVID-19 symptoms, recovery status, and duration of symptoms for those who had fully recovered. Questionnaires were date-stamped for estimation of COVID-19 symptom duration for those who had not recovered at their last follow-up. The UKMSR holds demographic and up-to-date clinical data on participants as well as their web-based Expanded Disability Status Scale (a measure of physical disability in MS) and Hospital Anxiety and Depression Scale scores. The association between these factors and recovery from COVID-19 was assessed using multivariable Cox regression analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Out of 7,977 people with MS who participated in the UKMSR COVID-19 study, 599 had COVID-19 and updated their recovery status prospectively. At least 181 participants (31.1%) had long-standing COVID-19 symptoms for ≥4 weeks and 76 (13.1 %) for ≥12 weeks. Participants with higher levels of pre-COVID-19 physical disability, participants with anxiety a
Choi S, Hill D, Guo L, et al., 2021, Automated Characterisation of Retinal Microglia in a Multiple Sclerosis Mouse Model and Age-Matched Controls, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Hillert J, Forsberg L, Manouchehrinia A, et al., 2021, Objective classification of multiple sclerosis disease course results in frequent reclassification to secondary progressive multiple sclerosis, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0028-3878
Ramsay S, McKee J, Kee R, et al., 2021, UK Multiple Sclerosis Register: Understanding the Gaps between Patient Experience and Patient Preference within outpatient clinics in the UK, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0028-3878
Garjani A, Nicholas R, Middleton R, et al., 2021, Determinants of Recovery from the Coronavirus Disease 2019 in People with Multiple Sclerosis: The UK MS Register COVID-19 Prospective Cohort Study, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0028-3878
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