Imperial College London
Alternate

DrRaffaelePalladino

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

r.palladino Website

 
 
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Location

 

309Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Picillo:2021:10.1007/s00415-020-10156-3,
author = {Picillo, M and Palladino, R and Erro, R and Alfano, R and Colosimo, C and Marconi, R and Antonini, A and Barone, P},
doi = {10.1007/s00415-020-10156-3},
journal = {Journal of Neurology},
pages = {448--454},
title = {The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease},
url = {http://dx.doi.org/10.1007/s00415-020-10156-3},
volume = {268},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivesTo explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages.MethodsA total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women).ResultsAs for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only.ConclusionsProdromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype.
AU  - Picillo,M
AU  - Palladino,R
AU  - Erro,R
AU  - Alfano,R
AU  - Colosimo,C
AU  - Marconi,R
AU  - Antonini,A
AU  - Barone,P
DO  - 10.1007/s00415-020-10156-3
EP  - 454
PY  - 2021///
SN  - 0340-5354
SP  - 448
TI  - The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease
T2  - Journal of Neurology
UR  - http://dx.doi.org/10.1007/s00415-020-10156-3
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000560637300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007%2Fs00415-020-10156-3#Abs1
UR  - http://hdl.handle.net/10044/1/85396
VL  - 268
ER  -
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