Imperial College London
Alternate

DrRaffaelePalladino

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

r.palladino Website

 
 
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Location

 

309Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Palladino:2021:10.1212/WNL.0000000000012610,
author = {Palladino, R and Chataway, J and Majeed, A and Marrie, RA},
doi = {10.1212/WNL.0000000000012610},
journal = {Neurology},
pages = {E1322--E1333},
title = {Interface of multiple sclerosis, depression, vascular disease, and mortality a population-based matched cohort study},
url = {http://dx.doi.org/10.1212/WNL.0000000000012610},
volume = {97},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background and Objectives To assess whether the association among depression, vascular disease, and mortality differs in people with multiple sclerosis (MS) compared with age-, sex-, and general practice–matched controls.Methods We conducted a population-based retrospective matched cohort study between January 1, 1987, and September 30, 2018, that included people with MS and matched controls without MS from England, stratified by depression status. We used time-varying Cox proportional hazard regression models to test the association among MS, depression, and time to incident vascular disease and mortality. Analyses were also stratified by sex.Results We identified 12,251 people with MS and 72,572 matched controls. At baseline, 21% of people with MS and 9% of controls had depression. Compared with matched controls without depression, people with MS had an increased risk of incident vascular disease regardless of whether they had comorbid depression. The 10-year hazard of all-cause mortality was 1.75-fold greater in controls with depression (95% confidence interval [CI] 1.59–1.91), 3.88-fold greater in people with MS without depression (95% CI 3.66–4.10), and 5.43-fold greater in people with MS and depression (95% CI 4.88–5.96). Overall, the interaction between MS status and depression was synergistic, with 14% of the observed effect attributable to the interaction. Sex-stratified analyses confirmed differences in hazard ratios.Discussion Depression is associated with increased risks of incident vascular disease and mortality in people with MS, and the effects of depression and MS on all-cause mortality are synergistic. Further studies should evaluate whether effectively treating depression is associated with a reduced risk of vascular disease and mortality.
AU  - Palladino,R
AU  - Chataway,J
AU  - Majeed,A
AU  - Marrie,RA
DO  - 10.1212/WNL.0000000000012610
EP  - 1333
PY  - 2021///
SN  - 0028-3878
SP  - 1322
TI  - Interface of multiple sclerosis, depression, vascular disease, and mortality a population-based matched cohort study
T2  - Neurology
UR  - http://dx.doi.org/10.1212/WNL.0000000000012610
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000702398400022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/92016
VL  - 97
ER  -
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