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@article{Evangelou:2021:10.7554/eLife.65325,
author = {Evangelou, E and Suzuki, H and Bai, W and Pazoki, R and Gao, H and Matthews, P and Elliott, P},
doi = {10.7554/eLife.65325},
journal = {eLife},
pages = {1--15},
title = {Alcohol consumption in the general population is associated with structural changes in multiple organ systems.},
url = {http://dx.doi.org/10.7554/eLife.65325},
volume = {10},
year = {2021}
}

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TY  - JOUR
AB  - Background:Excessive alcohol consumption is associated with damage to various organs, but its multi-organ effects have not been characterised across the usual range of alcohol drinking in a large general population sample.Methods:We assessed global effect sizes of alcohol consumption on quantitative magnetic resonance imaging phenotypic measures of the brain, heart, aorta, and liver of UK Biobank participants who reported drinking alcohol.Results:We found a monotonic association of higher alcohol consumption with lower normalised brain volume across the range of alcohol intakes (–1.7 × 10−3 ± 0.76 × 10−3 per doubling of alcohol consumption, p=3.0 × 10−14). Alcohol consumption was also associated directly with measures of left ventricular mass index and left ventricular and atrial volume indices. Liver fat increased by a mean of 0.15% per doubling of alcohol consumption.Conclusions:Our results imply that there is not a ‘safe threshold’ below which there are no toxic effects of alcohol. Current public health guidelines concerning alcohol consumption may need to be revisited.
AU  - Evangelou,E
AU  - Suzuki,H
AU  - Bai,W
AU  - Pazoki,R
AU  - Gao,H
AU  - Matthews,P
AU  - Elliott,P
DO  - 10.7554/eLife.65325
EP  - 15
PY  - 2021///
SN  - 2050-084X
SP  - 1
TI  - Alcohol consumption in the general population is associated with structural changes in multiple organ systems.
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.65325
UR  - https://elifesciences.org/articles/65325
UR  - http://hdl.handle.net/10044/1/89622
VL  - 10
ER  -

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