Imperial College London
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DrRahaPazoki

Faculty of Medicine, School of Public Health

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 1174r.pazoki

 
 
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Location

 

VC7Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pazoki:2019:10.1101/744045,
author = {Pazoki, R and Lin, BD and van, Eijk KR and Schijven, D and Guloksuz, S and Luykx, JJ},
doi = {10.1101/744045},
title = {Phenome-wide and Genome-wide Analyses of Quality of Life in Schizophrenia},
url = {http://dx.doi.org/10.1101/744045},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Schizophrenia negatively impacts quality of life (QoL). A handful of variables from small studies have been reported to influence QoL of schizophrenia patients, but a study comprehensively dissecting the genetic and non-genetic contributing factors to QoL in these patients is currently lacking. We adopted a hypothesis-generating approach to assess the phenotypic and genotypic determinants of QoL in schizophrenia.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>The study population consisted of 1,119 patients with a psychotic disorder, 1,979 relatives and 586 healthy controls. Using linear regression, we tested >100 independent demographic, cognitive and clinical phenotypes for their association with QoL in patients. We then performed genome-wide association analyses of QoL and examined the association between polygenic risk scores (PRSs) for schizophrenia, major depressive disorder (MDD), and subjective wellbeing (SW) with QoL.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We found nine phenotypes to be significantly and independently associated with QoL in patients, the most significant ones being negative (Beta=-1.17; SE=0.05, P=1×10<jats:sup>-83</jats:sup>; r<jats:sup>2</jats:sup>=53%), depressive (Beta=-1.07; SE=0.05; P=2×10<jats:sup>-79</jats:sup>; r<jats:sup>2</jats:sup>=51%) and emotional distress (Beta=-0.09; SE=0.01; P=4×10<jats:sup>-59</jats:sup>, r<jats:sup>2</jats:sup>=38%) symptoms. Schizophrenia and subjective wellbeing PRSs using various P-value thresholds were significantly and consistently associated with QoL (lowest association p-value = 6.8×10<jats:sup>-6</jats:sup>). Several sensitivity analyses confi
AU  - Pazoki,R
AU  - Lin,BD
AU  - van,Eijk KR
AU  - Schijven,D
AU  - Guloksuz,S
AU  - Luykx,JJ
DO  - 10.1101/744045
PY  - 2019///
TI  - Phenome-wide and Genome-wide Analyses of Quality of Life in Schizophrenia
UR  - http://dx.doi.org/10.1101/744045
ER  -
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