Imperial College London
Alternate

DrRobertPerneczky

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 0611r.perneczky

 
 
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Location

 

10L05Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Alexopoulos:2018:10.1159/000488481,
author = {Alexopoulos, P and Thierjung, N and Grimmer, T and Ortner, M and Economou, P and Assimakopoulos, K and Gourzis, P and Politis, A and Perneczky, R and TheAlzheimersDiseaseNeuroimagingInitiative},
doi = {10.1159/000488481},
journal = {Dementia and Geriatric Cognitive Disorders},
pages = {152--161},
title = {Cerebrospinal fluid BACE1 activity and sAβPPβ as biomarker candidates of Alzheimer's Disease},
url = {http://dx.doi.org/10.1159/000488481},
volume = {45},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND/AIMS: The utility of β-site amyloid-β precursor protein (AβPP) cleaving enzyme 1 (BACE1) activity and soluble AβPP β (sAβPPβ) levels in cerebrospinal fluid (CSF) in detecting Alzheimer's disease (AD) is still elusive. METHODS: BACE1 activity and sAβPPβ concentration were measured in patients with AD dementia (n = 56) and mild cognitive impairment (MCI) due to AD (n = 76) with abnormal routine AD CSF markers, in patients with MCI with normal CSF markers (n = 39), and in controls without preclinical AD (n = 48). In a subsample with available 18F-fluorodeoxyglucose positron emission tomography (FDG PET) data, ordinal regression models were employed to compare the contribution of BACE1 and sAβPPβ to correct diagnostic classification to that of FDG PET. RESULTS: BACE1 activity was significantly higher in patients with MCI due to AD compared to both controls and patients with MCI with normal CSF markers. sAβPPβ did not differ between any of the studied groups. Interestingly, BACE1 activity was not found to be inferior to FDG PET as predictive covariate in differentiating between the diagnostic groups. CONCLUSIONS: Further studies using biomarker-underpinned diagnoses are warranted to shed more light on the potential diagnostic utility of BACE1 activity as AD biomarker candidate in MCI.
AU  - Alexopoulos,P
AU  - Thierjung,N
AU  - Grimmer,T
AU  - Ortner,M
AU  - Economou,P
AU  - Assimakopoulos,K
AU  - Gourzis,P
AU  - Politis,A
AU  - Perneczky,R
AU  - TheAlzheimersDiseaseNeuroimagingInitiative
DO  - 10.1159/000488481
EP  - 161
PY  - 2018///
SN  - 1420-8008
SP  - 152
TI  - Cerebrospinal fluid BACE1 activity and sAβPPβ as biomarker candidates of Alzheimer's Disease
T2  - Dementia and Geriatric Cognitive Disorders
UR  - http://dx.doi.org/10.1159/000488481
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29788013
UR  - http://hdl.handle.net/10044/1/59716
VL  - 45
ER  -
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