Imperial College London
Alternate

DrRobertPerneczky

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 0611r.perneczky

 
 
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Location

 

10L05Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sadlon:2019:10.1016/j.molmed.2019.05.006,
author = {Sadlon, A and Takousis, P and Alexopoulos, P and Evangelou, E and Prokopenko, I and Perneczky, R},
doi = {10.1016/j.molmed.2019.05.006},
journal = {Trends in Molecular Medicine},
pages = {662--672},
title = {miRNAs identify shared pathways in Alzheimer's and Parkinson's Diseases},
url = {http://dx.doi.org/10.1016/j.molmed.2019.05.006},
volume = {25},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Despite the identification of several dozens of common genetic variants associated with Alzheimer’s disease (AD) and Parkinson’s disease (PD), most of the genetic risk remains uncharacterised. Therefore, it is important to understand the role of regulatory elements, such as miRNAs. Dysregulated miRNAs are implicated in AD and PD, with potential value in dissecting the shared pathophysiology between the two disorders. miRNAs relevant to both neurodegenerative diseases are related to axonal guidance, apoptosis, and inflammation, therefore, AD and PD likely arise from similar underlying biological pathway defects. Furthermore, pathways regulated by APP, L1CAM, and genes of the caspase family may represent promising therapeutic miRNA targets in AD and PD since they are targeted by dysregulated miRNAs in both disorders.
AU  - Sadlon,A
AU  - Takousis,P
AU  - Alexopoulos,P
AU  - Evangelou,E
AU  - Prokopenko,I
AU  - Perneczky,R
DO  - 10.1016/j.molmed.2019.05.006
EP  - 672
PY  - 2019///
SN  - 1471-4914
SP  - 662
TI  - miRNAs identify shared pathways in Alzheimer's and Parkinson's Diseases
T2  - Trends in Molecular Medicine
UR  - http://dx.doi.org/10.1016/j.molmed.2019.05.006
UR  - http://hdl.handle.net/10044/1/70945
VL  - 25
ER  -
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