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@article{Kolabas:2021:10.1101/2021.12.24.473988,
author = {Kolabas, ZI and Kuemmerle, LB and Perneczky, R and Förstera, B and Büttner, M and Caliskan, OS and Ali, M and Rong, Z and Mai, H and Hummel, S and Bartos, LM and Biechele, G and Zatcepin, A and Albert, NL and Unterrainer, M and Gnörich, J and Zhao, S and Khalin, I and Rauchmann, B-S and Molbay, M and Sterr, M and Kunze, I and Stanic, K and Besson-Girard, S and Kopczak, A and Katzdobler, S and Palleis, C and Gokce, O and Lickert, H and Steinke, H and Bechmann, I and Buerger, K and Levin, J and Haass, C and Dichgans, M and Havla, J and Kümpfel, T and Kerschensteiner, M and Simons, M and Plesnila, N and Krahmer, N and Bhatia, HS and Erener, S and Hellal, F and Brendel, M and Theis, FJ and Erturk, A},
doi = {10.1101/2021.12.24.473988},
title = {Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation},
url = {http://dx.doi.org/10.1101/2021.12.24.473988},
year = {2021}
}

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TY  - JOUR
AB  - <jats:title>SUMMARY</jats:title><jats:p>The meninges of the brain are an important component of neuroinflammatory response. Diverse immune cells move from the calvaria marrow into the dura mater via recently discovered skull-meninges connections (SMCs). However, how the calvaria bone marrow is different from the other bones and whether and how it contributes to human diseases remain unknown. Using multi-omics approaches and whole mouse transparency we reveal that bone marrow cells are highly heterogeneous across the mouse body. The calvaria harbors the most distinct molecular signature with hundreds of differentially expressed genes and proteins. Acute brain injury induces skull-specific alterations including increased calvaria cell numbers. Moreover, TSPO-positron-emission-tomography imaging of stroke, multiple sclerosis and neurodegenerative disease patients demonstrate disease-associated uptake patterns in the human skull, mirroring the underlying brain inflammation. Our study indicates that the calvaria is more than a physical barrier, and its immune cells may present new ways to control brain pathologies.</jats:p><jats:sec><jats:title>Graphical Abstract</jats:title><jats:fig id="ufig1" position="float" fig-type="figure" orientation="portrait"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="473988v1_ufig1" position="float" orientation="portrait" /></jats:fig></jats:sec><jats:sec><jats:title>Highlights</jats:title><jats:list list-type="order"><jats:list-item><jats:p>Bone marrow across the mouse body display heterogeneity in their molecular profile</jats:p></jats:list-item><jats:list-item><jats:p>Calvaria cells have a distinct profile that is relevant to brain pathologies</jats:p></jats:list-item><jats:list-item>&
AU  - Kolabas,ZI
AU  - Kuemmerle,LB
AU  - Perneczky,R
AU  - Förstera,B
AU  - Büttner,M
AU  - Caliskan,OS
AU  - Ali,M
AU  - Rong,Z
AU  - Mai,H
AU  - Hummel,S
AU  - Bartos,LM
AU  - Biechele,G
AU  - Zatcepin,A
AU  - Albert,NL
AU  - Unterrainer,M
AU  - Gnörich,J
AU  - Zhao,S
AU  - Khalin,I
AU  - Rauchmann,B-S
AU  - Molbay,M
AU  - Sterr,M
AU  - Kunze,I
AU  - Stanic,K
AU  - Besson-Girard,S
AU  - Kopczak,A
AU  - Katzdobler,S
AU  - Palleis,C
AU  - Gokce,O
AU  - Lickert,H
AU  - Steinke,H
AU  - Bechmann,I
AU  - Buerger,K
AU  - Levin,J
AU  - Haass,C
AU  - Dichgans,M
AU  - Havla,J
AU  - Kümpfel,T
AU  - Kerschensteiner,M
AU  - Simons,M
AU  - Plesnila,N
AU  - Krahmer,N
AU  - Bhatia,HS
AU  - Erener,S
AU  - Hellal,F
AU  - Brendel,M
AU  - Theis,FJ
AU  - Erturk,A
DO  - 10.1101/2021.12.24.473988
PY  - 2021///
TI  - Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation
UR  - http://dx.doi.org/10.1101/2021.12.24.473988
ER  -

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