Imperial College London
Alternate

DrRobertPerneczky

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 0611r.perneczky

 
 
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Location

 

10L05Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ersoezlue:2022:10.1101/2022.01.17.22269026,
author = {Ersoezlue, E and Perneczky, R and Tatò, M and Utecht, J and Kurz, C and Häckert, J and Guersel, S and Burow, L and Koller, G and Stöcklein, S and Keeser, D and Papazov, B and Totzke, M and Ballarini, T and Brosseron, F and Buerger, K and Dechent, P and Dobisch, L and Ewers, M and Fliessbach, K and Glanz, W and Haynes, JD and Heneka, MT and Janowitz, D and Kilimann, I and Kleineidam, L and Laske, C and Maier, F and Munk, MH and Peters, O and Priller, J and Ramirez, A and Röske, S and Roy, N and Scheffler, K and Schneider, A and Schott, BH and Spottke, A and Spruth, EJ and Teipel, S and Unterfeld, C and Wagner, M and Wang, X and Wiltfang, J and Wolfsgruber, S and Yakupov, R and Düzel, E and Jessen, F and Rauchmann, B-S},
doi = {10.1101/2022.01.17.22269026},
title = {A residual marker of cognitive reserve is associated with resting-state intrinsic functional connectivity along the Alzheimer’s disease continuum},
url = {http://dx.doi.org/10.1101/2022.01.17.22269026},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Cognitive reserve (CR) explains interindividual differences in the impact of neurodegenerative burden on cognitive and daily functioning. A residual model was proposed to estimate CR more accurately compared to static measures, such as years of education. However, the functional brain correlates of residual CR markers (CRM) remain unexplored.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>From the DELCODE cohort, 318 participants with resting-state functional and structural MRI data were included and stratified using cerebrospinal fluid (CSF) biomarkers according to the A(myloid-β, Aβ)/T(au)/N(eurodegeneration) classification scheme, resulting in 112 Aβ-negative healthy controls and 206 Aβ-positive patients in the Alzheimer’s disease (AD) spectrum.. CRM was calculated utilizing residuals obtained from a multilinear regression model using global cognition as dependent variable and demographic and disease burden measures as predictors. Associations between the CRM and intrinsic network connectivity (INC) in resting-state networks associated with cognition were explored, including the default mode network (DMN), frontoparietal network (FPN), salience network (SAL) and dorsal attention network (DAN). Moreover, the association between memory performance-associated regional INC and CRM was assessed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>CRM was positively associated with INC in the DMN in the entire cohort. In a subgroup analysis, the A+T+N+ group revealed an anti-correlation between SAL and DMN. Furthermore, CRM was positively associated with the anti-correlation between the memory-related regions in the FPN and the DMN in the A+ and A+T/N+ subgroups.</jats:p></jats:sec><jats:sec><j
AU  - Ersoezlue,E
AU  - Perneczky,R
AU  - Tatò,M
AU  - Utecht,J
AU  - Kurz,C
AU  - Häckert,J
AU  - Guersel,S
AU  - Burow,L
AU  - Koller,G
AU  - Stöcklein,S
AU  - Keeser,D
AU  - Papazov,B
AU  - Totzke,M
AU  - Ballarini,T
AU  - Brosseron,F
AU  - Buerger,K
AU  - Dechent,P
AU  - Dobisch,L
AU  - Ewers,M
AU  - Fliessbach,K
AU  - Glanz,W
AU  - Haynes,JD
AU  - Heneka,MT
AU  - Janowitz,D
AU  - Kilimann,I
AU  - Kleineidam,L
AU  - Laske,C
AU  - Maier,F
AU  - Munk,MH
AU  - Peters,O
AU  - Priller,J
AU  - Ramirez,A
AU  - Röske,S
AU  - Roy,N
AU  - Scheffler,K
AU  - Schneider,A
AU  - Schott,BH
AU  - Spottke,A
AU  - Spruth,EJ
AU  - Teipel,S
AU  - Unterfeld,C
AU  - Wagner,M
AU  - Wang,X
AU  - Wiltfang,J
AU  - Wolfsgruber,S
AU  - Yakupov,R
AU  - Düzel,E
AU  - Jessen,F
AU  - Rauchmann,B-S
DO  - 10.1101/2022.01.17.22269026
PY  - 2022///
TI  - A residual marker of cognitive reserve is associated with resting-state intrinsic functional connectivity along the Alzheimer’s disease continuum
UR  - http://dx.doi.org/10.1101/2022.01.17.22269026
ER  -
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