Publications
178 results found
Peters R, Ee N, Peters J, et al., 2019, Common risk factors for major noncommunicable disease, a systematic overview of reviews and commentary: the implied potential for targeted risk reduction, THERAPEUTIC ADVANCES IN CHRONIC DISEASE, Vol: 10, ISSN: 2040-6223
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- Citations: 65
Peters R, Warwick J, Anstey KJ, et al., 2019, Blood pressure and dementia What the SPRINT-MIND trial adds and what we still need to know, NEUROLOGY, Vol: 92, Pages: 1017-1018, ISSN: 0028-3878
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- Citations: 48
Tully PJ, Helmer C, Peters R, et al., 2019, Exploiting Drug-Apolipoprotein E Gene Interactions in Hypertension to Preserve Cognitive Function: The 3-City Cohort Study, JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, Vol: 20, Pages: 188-+, ISSN: 1525-8610
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- Citations: 2
Peters R, Beckett N, Antikainen R, et al., 2019, Subjective memory complaints and incident dementia in a high risk older adult hypertensive population, AGE AND AGEING, Vol: 48, Pages: 253-259, ISSN: 0002-0729
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- Citations: 10
Peters R, 2019, No clear relationship between antihypertensive class and cognitive function over 12 months in a cohort study of community-dwelling adults aged 80 and over, THERAPEUTIC ADVANCES IN CHRONIC DISEASE, Vol: 10, Pages: 1-9, ISSN: 2040-6223
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- Citations: 5
Peters R, Booth A, Rockwood K, et al., 2019, Combining modifiable risk factors and risk of dementia: a systematic review and meta-analysis, BMJ Open, Vol: 9, ISSN: 2044-6055
OBJECTIVE: To systematically review the literature relating to the impact of multiple co-occurring modifiable risk factors for cognitive decline and dementia. DESIGN: A systematic review and meta-analysis of the literature relating to the impact of co-occurring key risk factors for incident cognitive decline and dementia. All abstracts and full text were screened independently by two reviewers and each article assessed for bias using a standard checklist. A fixed effects meta-analysis was undertaken. DATA SOURCES: Databases Medline, Embase and PsycINFO were searched from 1999 to 2017. ELIGIBILITY CRITERIA: For inclusion articles were required to report longitudinal data from participants free of cognitive decline at baseline, with formal assessment of cognitive function or dementia during follow-up, and an aim to examine the impact of additive or clustered comorbid risk factor burden in with two or more core modifiable risk factors. RESULTS: Seventy-nine full-text articles were examined. Twenty-two articles (18 studies) were included reporting data on >40 000 participants. Included studies consistently reported an increased risk associated with greater numbers of intraindividual risk factors or unhealthy behaviours and the opposite for healthy or protective behaviours. A meta-analysis of studies with dementia outcomes resulted in a pooled relative risk for dementia of 1.20 (95% CI 1.04 to 1.39) for one risk factor, 1.65 (95% CI 1.40 to 1.94) for two and 2.21 (95% CI 1.78 to 2.73) for three or more, relative to no risk factors. Limitations include dependence on published results and variations in study outcome, cognitive assessment, length of follow-up and definition of risk factor exposure. CONCLUSIONS: The strength of the reported associations, the consistency across studies and the suggestion of a dose response supports a need to keep modifiable risk factor exposure to a minimum and to avoid exposure to additional modifiable risks. Further research is ne
Anstey KJ, Ee N, Eramudugolla R, et al., 2019, A Systematic Review of Meta-Analyses that Evaluate Risk Factors for Dementia to Evaluate the Quantity, Quality, and Global Representativeness of Evidence, JOURNAL OF ALZHEIMERS DISEASE, Vol: 70, Pages: S165-S186, ISSN: 1387-2877
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- Citations: 77
Anstey KJ, Peters R, 2019, Dementia, Risk, Risk Reduction, and Translation into Practice: An International Research Network for Dementia Prevention (IRNDP) Special Issue, JOURNAL OF ALZHEIMERS DISEASE, Vol: 70, Pages: S1-S3, ISSN: 1387-2877
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- Citations: 4
Peters R, Ee N, Peters J, et al., 2019, Air Pollution and Dementia: A Systematic Review, JOURNAL OF ALZHEIMERS DISEASE, Vol: 70, Pages: S145-S163, ISSN: 1387-2877
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- Citations: 250
Hosking DE, Ayton S, Beckett N, et al., 2018, More evidence is needed. Iron, incident cognitive decline and dementia: a systematic review, THERAPEUTIC ADVANCES IN CHRONIC DISEASE, Vol: 9, Pages: 241-256, ISSN: 2040-6223
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- Citations: 10
Anstey KJ, Peters R, 2018, Alcohol and dementia - risk or protective factor?, NATURE REVIEWS NEUROLOGY, Vol: 14, Pages: 635-636, ISSN: 1759-4758
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- Citations: 6
Tully PJ, Turnbull DA, Anstey KJ, et al., 2018, The association between blood pressure variability (BPV) with dementia and cognitive function: a systematic review and meta-analysis protocol, SYSTEMATIC REVIEWS, Vol: 7
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- Citations: 10
Peters R, Anstey KJ, Booth A, et al., 2018, Orthostatic hypotension and symptomatic subclinical orthostatic hypotension increase risk of cognitive impairment: an integrated evidence review and analysis of a large older adult hypertensive cohort, EUROPEAN HEART JOURNAL, Vol: 39, Pages: 3135-3143, ISSN: 0195-668X
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- Citations: 38
Tully PJ, Peters R, Peres K, et al., 2018, Effect of SSRI and calcium channel blockers on depression symptoms and cognitive function in elderly persons treated for hypertension: three city cohort study, INTERNATIONAL PSYCHOGERIATRICS, Vol: 30, Pages: 1345-1354, ISSN: 1041-6102
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- Citations: 11
Mortby ME, Peters R, 2018, Greater cognitive decline relative to normal ageing occurs at least 10 years prior to clinical dementia diagnosis, BMJ EVIDENCE-BASED MEDICINE, Vol: 23, Pages: 79-+, ISSN: 2515-446X
Skrobot OA, Black SE, Chen C, et al., 2018, Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study, ALZHEIMERS & DEMENTIA, Vol: 14, Pages: 280-292, ISSN: 1552-5260
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- Citations: 171
Peters RK, Mack TM, Garabrant DH, et al., 2018, Calcium and colon cancer in Los Angeles county, Calcium, Vitamin D, and Prevention of Colon Cancer, Pages: 113-119, ISBN: 9781315891286
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- Citations: 3
Radford K, Lavrencic L, Peters R, et al., 2018, Can adult mental health be predicted by childhood future-self narratives? Insights from the CLPsych 2018 Shared Task, Pages: 126-135
The CLPsych 2018 Shared Task B explores how childhood essays can predict psychological distress throughout the author's life. Our main aim was to build tools to help our psychologists understand the data, propose features and interpret predictions. We submitted two linear regression models: MODELA uses simple demographic and word-count features, while MODELB uses linguistic, entity, typographic, expert-gazetteer, and readability features. Our models perform best at younger prediction ages, with our best unofficial score at 23 of 0.426 disattenuated Pearson correlation. This task is challenging and although predictive performance is limited, we propose that tight integration of expertise across computational linguistics and clinical psychology is a productive direction.
Anstey KJ, Peters R, 2018, Oversimplification of Dementia Risk Reduction Messaging Is a Threat to Knowledge Translation in Dementia Prevention Research, JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE, Vol: 5, Pages: 2-4, ISSN: 2274-5807
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- Citations: 8
Anstey KJ, Peters R, Clare L, et al., 2017, Joining forces to prevent dementia: The International Research Network On Dementia Prevention (IRNDP), INTERNATIONAL PSYCHOGERIATRICS, Vol: 29, Pages: 1757-1760, ISSN: 1041-6102
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- Citations: 18
Malhotra R, Hoang AN, Benavente O, et al., 2017, Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5 A Systematic Review and Meta-analysis, JAMA INTERNAL MEDICINE, Vol: 177, Pages: 1498-1505, ISSN: 2168-6106
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- Citations: 124
Skrobot OA, O'Brien J, Black S, et al., 2017, The Vascular Impairment of Cognition Classification Consensus Study, ALZHEIMERS & DEMENTIA, Vol: 13, Pages: 624-633, ISSN: 1552-5260
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- Citations: 103
Bulpitt CJ, Webb R, Beckett N, et al., 2017, Antihypertensive treatment decreases arterial stiffness at night but not during the day. Results from the Hypertension in the Very Elderly Trial, BLOOD PRESSURE, Vol: 26, Pages: 109-114
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- Citations: 1
Anstey KJ, Ashby-Mitchell K, Peters R, 2017, Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis, JOURNAL OF ALZHEIMERS DISEASE, Vol: 56, Pages: 215-228, ISSN: 1387-2877
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- Citations: 188
Antikainen RL, Peters R, Beckett NS, et al., 2016, Left ventricular hypertrophy is a predictor of cardiovascular events in elderly hypertensive patients: Hypertension in the Very Elderly Trial, JOURNAL OF HYPERTENSION, Vol: 34, Pages: 2280-2286, ISSN: 0263-6352
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- Citations: 27
Yasar S, Schuchman M, Peters J, et al., 2016, Relationship between antihypertensive medications and cognitive impairment: Part I. review of human studies and clinical trials, Current Hypertension Reports, Vol: 18, ISSN: 1534-3111
Purpose of review:There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHMs) and dementia risk are less consistent. An increased interest in AHM has resulted in expanding publications; however, none of the recent reviews are comprehensive. Our extensive review includes 15 observational and randomized controlled trials (RCTs) published over the last 5 years, assessing the relationship between AHM and cognitive impairment.Recent findings:All classes of AHM showed similar result patterns in human studies with the majority of study results reporting point estimates below one and only a small number of studies (N = 15) reporting statistically significant results in favor of a specific class.Summary:Only a small number of studies reported statistically significant results in favor of a specific class of AHM. Methodological limitations of the studies prevent definitive conclusions. Further work is now needed to evaluate the class of AHM and cognitive outcomes in future RCTs, with a particular focus on the drugs with the promising results in both animals and human observational studies.
Peters R, Schuchman M, Peters J, et al., 2016, Relationship between antihypertensive medications and cognitive impairment: Part II. Review of Physiology and animal studies, Current Hypertension Reports, Vol: 18, ISSN: 1534-3111
Purpose of ReviewThere is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHM) and dementia risk are less clear. An increased interest in AHM has resulted in expanding publications; however, none of the recent reviews provide comprehensive review. Our extensive review includes 24 mechanistic animal and human studies published over the last 5 years assessing relationship between AHM and cognitive function.Recent FindingsAll classes of AHM showed similar result patterns in animal studies. The mechanism by which AHM exert their effect was extensively studied by evaluating well-established pathways of AD disease process, including amyloid beta (Aβ), vascular, oxidative stress and inflammation pathways, but only few studies evaluated the blood pressure lowering effect on the AD disease process.SummaryMethodological limitations of the studies prevent comprehensive conclusions prior to further work evaluating AHM in animals and larger human observational studies, and selecting those with promising results for future RCTs.
Pedditzi E, Peters R, Beckett N, 2016, Corrigendum to 'The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies', Age and Ageing, ISSN: 1468-2834
Chatterjee S, Peters SAE, Woodward M, et al., 2016, Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia, Diabetes Care, Vol: 39, Pages: 300-307, ISSN: 1935-5548
OBJECTIVE Type 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. Diabetes is also a risk factor for dementia, but whether the association is similar in women and men remains unknown. We performed a meta-analysis of unpublished data to estimate the sex-specific relationship between women and men with diabetes with incident dementia.RESEARCH DESIGN AND METHODS A systematic search identified studies published prior to November 2014 that had reported on the prospective association between diabetes and dementia. Study authors contributed unpublished sex-specific relative risks (RRs) and 95% CIs on the association between diabetes and all dementia and its subtypes. Sex-specific RRs and the women-to-men ratio of RRs (RRRs) were pooled using random-effects meta-analyses.RESULTS Study-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. In multiple-adjusted analyses, diabetes was associated with a 60% increased risk of any dementia in both sexes (women: pooled RR 1.62 [95% CI 1.45–1.80]; men: pooled RR 1.58 [95% CI 1.38–1.81]). The diabetes-associated RRs for vascular dementia were 2.34 (95% CI 1.86–2.94) in women and 1.73 (95% CI 1.61–1.85) in men, and for nonvascular dementia, the RRs were 1.53 (95% CI 1.35–1.73) in women and 1.49 (95% CI 1.31–1.69) in men. Overall, women with diabetes had a 19% greater risk for the development of vascular dementia than men (multiple-adjusted RRR 1.19 [95% CI 1.08–1.30]; P < 0.001).CONCLUSIONS Individuals with type 2 diabetes are at ∼60% greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.
Pedditizi E, Peters R, Beckett N, 2016, The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies, Age and Ageing, Vol: 45, Pages: 14-21, ISSN: 1468-2834
Scope: it has been suggested that overweight/obesity as a risk factor for incident dementia differs between mid-life and later life. We performed a systematic review and meta-analysis of the up-to-date current literature to assess this.Search Methods: inclusion criteria included epidemiological longitudinal studies published up to September 2014, in participants without cognitive impairment based on evidence of cognitive assessment and aged 30 or over at baseline assessment with at least 2 years of follow-up. Pubmed, Medline, EMBASE, PsychInfo and the Cochrane Library were searched using combinations of the search terms: Dementia, Alzheimer disease, Vascular Dementia, Multi-Infarct Dementia, Cognitive decline, Cognitive impairment, Mild Cognitive Impairment/Obesity, Overweight, Adiposity, Waist circumference (limits: humans, English language). Handsearching of all papers meeting the inclusion criteria was performed. A random-effects model was used for the meta-analysis.Results: of the 1,612 abstracts identified and reviewed, 21 completely met the inclusion criteria. Being obese below the age of 65 years had a positive association on incident dementia with a risk ratio (RR) 1.41 (95% confidence interval, CI: 1.20–1.66), but the opposite was seen in those aged 65 and over, RR 0.83 (95% CI: 0.74–0.94).Conclusions: this systematic review and meta-analysis suggests a positive association between obesity in mid-life and later dementia but the opposite in late life. Whether weight reduction in mid-life reduces risk is worthy of further study.
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