Imperial College London
Portrait Picture

Dr Ricardo Petraco

Faculty of Medicine, National Heart & Lung Institute

Honorary Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 7594 3386r.petraco

 
 
//

Location

 

Block B Hammersmith HospitalHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Kikuta:2018:10.1016/j.jcin.2018.03.005,
author = {Kikuta, Y and Cook, CM and Sharp, ASP and Salinas, P and Kawase, Y and Shiono, Y and Giavarini, A and Nakayama, M and De, Rosa S and Sen, S and Nijjer, SS and Al-Lamee, R and Petraco, R and Malik, IS and Mikhail, GW and Kaprielian, RR and Wijntjens, GWM and Mori, S and Hagikura, A and Mates, M and Mizuno, A and Hellig, F and Lee, K and Janssens, L and Horie, K and Mohdnazri, S and Herrera, R and Krackhardt, F and Yamawaki, M and Davies, J and Takebayashi, H and Keeble, T and Haruta, S and Ribichini, F and Indolfi, C and Mayet, J and Francis, DP and Piek, JJ and Di, Mario C and Escaned, J and Matsuo, H and Davies, JE},
doi = {10.1016/j.jcin.2018.03.005},
journal = {JACC-CARDIOVASCULAR INTERVENTIONS},
pages = {757--767},
title = {Pre-Angioplasty Instantaneous Wave-Free Ratio Pullback Predicts Hemodynamic Outcome In Humans With Coronary Artery Disease Primary Results of the International Multicenter iFR GRADIENT Registry},
url = {http://dx.doi.org/10.1016/j.jcin.2018.03.005},
volume = {11},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivesThe authors sought to evaluate the accuracy of instantaneous wave-Free Ratio (iFR) pullback measurements to predict post-percutaneous coronary intervention (PCI) physiological outcomes, and to quantify how often iFR pullback alters PCI strategy in real-world clinical settings.BackgroundIn tandem and diffuse disease, offline analysis of continuous iFR pullback measurement has previously been demonstrated to accurately predict the physiological outcome of revascularization. However, the accuracy of the online analysis approach (iFR pullback) remains untested.MethodsAngiographically intermediate tandem and/or diffuse lesions were entered into the international, multicenter iFR GRADIENT (Single instantaneous wave-Free Ratio Pullback Pre-Angioplasty Predicts Hemodynamic Outcome Without Wedge Pressure in Human Coronary Artery Disease) registry. Operators were asked to submit their procedural strategy after angiography alone and then after iFR-pullback measurement incorporating virtual PCI and post-PCI iFR prediction. PCI was performed according to standard clinical practice. Following PCI, repeat iFR assessment was performed and the actual versus predicted post-PCI iFR values compared.ResultsMean age was 67 ± 12 years (81% male). Paired pre- and post-PCI iFR were measured in 128 patients (134 vessels). The predicted post-PCI iFR calculated online was 0.93 ± 0.05; observed actual iFR was 0.92 ± 0.06. iFR pullback predicted the post-PCI iFR outcome with 1.4 ± 0.5% error. In comparison to angiography-based decision making, after iFR pullback, decision making was changed in 52 (31%) of vessels; with a reduction in lesion number (−0.18 ± 0.05 lesion/vessel; p = 0.0001) and length (−4.4 ± 1.0 mm/vessel; p < 0.0001).ConclusionsIn tandem and diffuse coronary disease, iFR pullback predicted the physiological outcome of PCI with a high degree of accuracy. Compared with angiography alone, availability of iFR pullback
AU  - Kikuta,Y
AU  - Cook,CM
AU  - Sharp,ASP
AU  - Salinas,P
AU  - Kawase,Y
AU  - Shiono,Y
AU  - Giavarini,A
AU  - Nakayama,M
AU  - De,Rosa S
AU  - Sen,S
AU  - Nijjer,SS
AU  - Al-Lamee,R
AU  - Petraco,R
AU  - Malik,IS
AU  - Mikhail,GW
AU  - Kaprielian,RR
AU  - Wijntjens,GWM
AU  - Mori,S
AU  - Hagikura,A
AU  - Mates,M
AU  - Mizuno,A
AU  - Hellig,F
AU  - Lee,K
AU  - Janssens,L
AU  - Horie,K
AU  - Mohdnazri,S
AU  - Herrera,R
AU  - Krackhardt,F
AU  - Yamawaki,M
AU  - Davies,J
AU  - Takebayashi,H
AU  - Keeble,T
AU  - Haruta,S
AU  - Ribichini,F
AU  - Indolfi,C
AU  - Mayet,J
AU  - Francis,DP
AU  - Piek,JJ
AU  - Di,Mario C
AU  - Escaned,J
AU  - Matsuo,H
AU  - Davies,JE
DO  - 10.1016/j.jcin.2018.03.005
EP  - 767
PY  - 2018///
SN  - 1936-8798
SP  - 757
TI  - Pre-Angioplasty Instantaneous Wave-Free Ratio Pullback Predicts Hemodynamic Outcome In Humans With Coronary Artery Disease Primary Results of the International Multicenter iFR GRADIENT Registry
T2  - JACC-CARDIOVASCULAR INTERVENTIONS
UR  - http://dx.doi.org/10.1016/j.jcin.2018.03.005
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000430387500010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/60907
VL  - 11
ER  -
Download