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@article{Karyotaki:2021:10.1001/jamapsychiatry.2020.4364,
author = {Karyotaki, E and Efthimiou, O and Miguel, C and Bermpohl, FMG and Furukawa, TA and Cuijpers, P and Riper, H and Patel, V and Mira, A and Gemmil, AW and Yeung, AS and Lange, A and Williams, AD and Mackinnon, A and Geraedts, A and van, Straten A and Meyer, B and Björkelund, C and Knaevelsrud, C and Beevers, CG and Botella, C and Strunk, DR and Mohr, DC and Ebert, DD and Kessler, D and Richards, D and Littlewood, E and Forsell, E and Feng, F and Wang, F and Andersson, G and Hadjistavropoulos, H and Christensen, H and Ezawa, ID and Choi, I and Rosso, IM and Klein, JP and Shumake, J and Garcia-Campayo, J and Milgrom, J and Smith, J and Montero-Marin, J and Newby, JM and Bretón-López, J and Schneider, J and Vernmark, K and Bücker, L and Sheeber, LB and Warmerdam, L and Farrer, L and Heinrich, M and Huibers, MJH and Kivi, M and Kraepelien, M and Forand, NR and Pugh, N and Lindefors, N and Lintvedt, O and Zagorscak, P and Carlbring, P and Phillips, R and Johansson, R and Kessler, RC and Brabyn},
doi = {10.1001/jamapsychiatry.2020.4364},
journal = {JAMA Psychiatry},
title = {Internet-based cognitive behavioral therapy for depression},
url = {http://dx.doi.org/10.1001/jamapsychiatry.2020.4364},
year = {2021}
}

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TY  - JOUR
AB  - Importance  Personalized treatment choices would increase the effectiveness of internet-based cognitive behavioral therapy (iCBT) for depression to the extent that patients differ in interventions that better suit them.Objective  To provide personalized estimates of short-term and long-term relative efficacy of guided and unguided iCBT for depression using patient-level information.Data Sources  We searched PubMed, Embase, PsycInfo, and Cochrane Library to identify randomized clinical trials (RCTs) published up to January 1, 2019.Study Selection  Eligible RCTs were those comparing guided or unguided iCBT against each other or against any control intervention in individuals with depression. Available individual patient data (IPD) was collected from all eligible studies. Depression symptom severity was assessed after treatment, 6 months, and 12 months after randomization.Data Extraction and Synthesis  We conducted a systematic review and IPD network meta-analysis and estimated relative treatment effect sizes across different patient characteristics through IPD network meta-regression.Main Outcomes and Measures  Patient Health Questionnaire–9 (PHQ-9) scores.Results  Of 42 eligible RCTs, 39 studies comprising 9751 participants with depression contributed IPD to the IPD network meta-analysis, of which 8107 IPD were synthesized. Overall, both guided and unguided iCBT were associated with more effectiveness as measured by PHQ-9 scores than control treatments over the short term and the long term. Guided iCBT was associated with more effectiveness than unguided iCBT (mean difference [MD] in posttreatment PHQ-9 scores, −0.8; 95% CI, −1.4 to −0.2), but we found no evidence of a difference at 6 or 12 months following randomization. Baseline depression was found to be the most important modifier of the relative association for efficacy of guided vs unguided iCBT. Differences between unguided and guided iCBT in people with baseline symptoms of subthreshol
AU  - Karyotaki,E
AU  - Efthimiou,O
AU  - Miguel,C
AU  - Bermpohl,FMG
AU  - Furukawa,TA
AU  - Cuijpers,P
AU  - Riper,H
AU  - Patel,V
AU  - Mira,A
AU  - Gemmil,AW
AU  - Yeung,AS
AU  - Lange,A
AU  - Williams,AD
AU  - Mackinnon,A
AU  - Geraedts,A
AU  - van,Straten A
AU  - Meyer,B
AU  - Björkelund,C
AU  - Knaevelsrud,C
AU  - Beevers,CG
AU  - Botella,C
AU  - Strunk,DR
AU  - Mohr,DC
AU  - Ebert,DD
AU  - Kessler,D
AU  - Richards,D
AU  - Littlewood,E
AU  - Forsell,E
AU  - Feng,F
AU  - Wang,F
AU  - Andersson,G
AU  - Hadjistavropoulos,H
AU  - Christensen,H
AU  - Ezawa,ID
AU  - Choi,I
AU  - Rosso,IM
AU  - Klein,JP
AU  - Shumake,J
AU  - Garcia-Campayo,J
AU  - Milgrom,J
AU  - Smith,J
AU  - Montero-Marin,J
AU  - Newby,JM
AU  - Bretón-López,J
AU  - Schneider,J
AU  - Vernmark,K
AU  - Bücker,L
AU  - Sheeber,LB
AU  - Warmerdam,L
AU  - Farrer,L
AU  - Heinrich,M
AU  - Huibers,MJH
AU  - Kivi,M
AU  - Kraepelien,M
AU  - Forand,NR
AU  - Pugh,N
AU  - Lindefors,N
AU  - Lintvedt,O
AU  - Zagorscak,P
AU  - Carlbring,P
AU  - Phillips,R
AU  - Johansson,R
AU  - Kessler,RC
AU  - Brabyn,S
AU  - Perini,S
AU  - Rauch,SL
AU  - Gilbody,S
AU  - Moritz,S
AU  - Berger,T
AU  - Pop,V
AU  - Kaldo,V
AU  - Spek,V
AU  - Forsell,Y
DO  - 10.1001/jamapsychiatry.2020.4364
PY  - 2021///
SN  - 2168-622X
TI  - Internet-based cognitive behavioral therapy for depression
T2  - JAMA Psychiatry
UR  - http://dx.doi.org/10.1001/jamapsychiatry.2020.4364
UR  - https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2774861
ER  -

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